Interactive association of metals and Life’s Essential 8 with mortality in U.S. adults: a prospective cohort study from the NHANES dataset DOI Creative Commons
Weipeng Zhang, Weiqiang Chen,

Dengqiu Lu

et al.

BMC Public Health, Journal Year: 2024, Volume and Issue: 24(1)

Published: Nov. 6, 2024

Life's Essential 8 (LE8) is a novel assessment of cardiovascular health (CVH) by evaluating lifestyle, and reports the associations between LE8 urinary metals on mortality have been very limited. This study aimed to conduct prospective cohort investigate combined effects in U.S. adults. enrolled participants with complete information metals, LE8, status, confounders from National Health Nutrition Examination Survey (2005–2018). The Cox regression model, adaptive lasso penalized regression, restricted cubic spline were used analyze individual all-cause mortality. additive multiplicative interaction scales quantile g-computation evaluate effects. Stratified analyses performed clarify whether interacted other variables influence A total 8017 included this study. concentrations cadmium, cobalt, lead, antimony, thorium greater low CVH group than high [median (µg/L): 0.29 vs. 0.19, 0.36 0.35, 0.48 0.39, 0.05 0.04, 0.07 0.06]. cadmium was statistically significant, synergy index 1.169 (95% CI: 1.004, 1.361). stratified showed that age had an impact (P for = 0.004). In representative sample population, we found effect thallium, positively associated Furthermore, influenced So people should adopt healthy behaviors reduce heavy metal exposure minimize risk adverse outcomes.

Language: Английский

Association of combined lead, cadmium, and mercury with systemic inflammation DOI Creative Commons
Emmanuel Obeng-Gyasi, Barnabas Obeng-Gyasi

Frontiers in Public Health, Journal Year: 2024, Volume and Issue: 12

Published: Aug. 29, 2024

Background Exposure to environmental metals has been increasingly associated with systemic inflammation, which is implicated in the pathogenesis of various chronic diseases, including those neurodegenerative aspects. However, complexity exposure and response relationships, particularly for mixtures metals, not fully elucidated. Objective This study aims assess individual combined effects lead, cadmium, mercury on inflammation as measured by C-reactive protein (CRP) levels, using data from National Health Nutrition Examination Survey (NHANES) 2017-2018. Methods We employed Bayesian Kernel Machine Regression (BKMR) analyze NHANES 2017-2018 data, allowing evaluation non-linear exposure-response functions interactions between metals. Posterior Inclusion Probabilities (PIP) were calculated determine significance each metal's contribution CRP levels. Results The PIP results highlighted mercury's significant levels (PIP = 1.000), followed cadmium 0.6456) lead 0.3528). Group values confirmed importance considering a collective group relation Our BKMR analysis revealed relationships metal exposures Univariate showed flat relationship CRP, having positive relationship. Mercury exhibited U-shaped association, indicating both low high potential risk factors increased inflammation. Bivariate this when contaminants cadmium. Analysis single-variable suggested that are higher h function, flexible function takes multiple combines them way captures complex potentially nonlinear CRP. overall effect all below 50th percentile level an increase while above 60th linked decrease Conclusions findings suggest mercury, These highlight need public health strategies address cumulative reinforce advanced statistical methods understand impact contaminants. Future research should focus mechanistic pathways metal-induced longitudinal studies ascertain long-term these exposures.

Language: Английский

Citations

3
Nonlinearity association of blood cobalt with the risk of anemia among middle-aged and older adults: National Health and Nutrition Examination Survey DOI Creative Commons
Xia Wang, Zhang Ye,

Xuntao Liu

et al.

Hematology, Journal Year: 2024, Volume and Issue: 29(1)

Published: Oct. 16, 2024

The use of cobalt alloys in medical implants poses a high risk exposure, yet there is lack evidence regarding the association between blood levels and anemia. This study aimed to explore link onset anemia identify potential threshold that could affect

Language: Английский

Citations

1
Interactive association of metals and Life’s Essential 8 with mortality in U.S. adults: a prospective cohort study from the NHANES dataset DOI Creative Commons
Weipeng Zhang, Weiqiang Chen,

Dengqiu Lu

et al.

BMC Public Health, Journal Year: 2024, Volume and Issue: 24(1)

Published: Nov. 6, 2024

Life's Essential 8 (LE8) is a novel assessment of cardiovascular health (CVH) by evaluating lifestyle, and reports the associations between LE8 urinary metals on mortality have been very limited. This study aimed to conduct prospective cohort investigate combined effects in U.S. adults. enrolled participants with complete information metals, LE8, status, confounders from National Health Nutrition Examination Survey (2005–2018). The Cox regression model, adaptive lasso penalized regression, restricted cubic spline were used analyze individual all-cause mortality. additive multiplicative interaction scales quantile g-computation evaluate effects. Stratified analyses performed clarify whether interacted other variables influence A total 8017 included this study. concentrations cadmium, cobalt, lead, antimony, thorium greater low CVH group than high [median (µg/L): 0.29 vs. 0.19, 0.36 0.35, 0.48 0.39, 0.05 0.04, 0.07 0.06]. cadmium was statistically significant, synergy index 1.169 (95% CI: 1.004, 1.361). stratified showed that age had an impact (P for = 0.004). In representative sample population, we found effect thallium, positively associated Furthermore, influenced So people should adopt healthy behaviors reduce heavy metal exposure minimize risk adverse outcomes.

Language: Английский

Citations

0