Unveiling the therapeutic potential of ferroptosis in lung cancer: a comprehensive bibliometric analysis and future therapeutic insights

Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)

Published: April 10, 2025

Lung cancer remains the leading cause of cancer-related deaths worldwide, with increasing attention being given to novel therapeutic strategies that target mechanisms underlying tumor growth and drug resistance. Among these, ferroptosis, a regulated cell death driven by iron-dependent lipid peroxidation, has become key focus in research. Despite extensive research, exact role ferroptosis lung progression treatment unclear, especially regarding its interaction immune cells microenvironment. To address these limitations, this study utilizes comprehensive bibliometric analysis explore current landscape research cancer. We collected data from Web Science Core Collection, covering articles published between 2015 2025, analyzed them using advanced tools such as VOSviewer CiteSpace. This uses uncover trends emerging areas related Recently, shifted basic clinical applications, particularly developing GPX4-targeted therapies combination treatments. With international collaboration, United States China have players. Interdisciplinary on cancer-immune system, offers new insights into microenvironment immunotherapy. Ferroptosis shows excellent promise overcoming resistance regulating peroxidation enhancing efficacy. Future should ferroptosis' translation, personalized medicine resistance, offering broad prospects for treatment. paper provides valuable trends, contributors, frontiers It identifies important developments can serve foundation translating ferroptosis-based practice,

Language: Английский

Research Hotspots and Frontier Trends of Autophagy in Diabetic Cardiomyopathy From 2014 to 2024: A Bibliometric Analysis

Journal of Multidisciplinary Healthcare, Journal Year: 2025, Volume and Issue: Volume 18, P. 837 - 860

Published: Feb. 1, 2025

In recent years, the investigation of autophagy mechanisms has gained prominence as a key focus for understanding pathogenesis and therapeutic potential diabetic cardiomyopathy. This study aims to present an overview current state, major research areas, emerging trends in related cardiomyopathy through bibliometric analysis, offering scientific foundation future research. The Web Science Core Collection served data source this study, from which full-text publications were extracted. Using CiteSpace 6.3.R1, VOSviewer v1.6.18, R-Bibliometrix, analysis evaluated output across dimensions such subjects, countries, institutions, journals, authors, co-cited references, generating comprehensive visual map. A total 367 met inclusion criteria. Between 2014 2024, volume articles demonstrated consistent upward trajectory. Research on predominantly spans disciplines biology medicine. China Fourth Military Medical University emerged leading contributors among 41 countries 505 institutions. Sun Dongdong was identified most prolific author, while Jia GH frequently cited. Key journals field include Biochimica et Biophysica Acta - Molecular Basis Disease Frontiers Cardiovascular Medicine, Circulation recorded highest number co-citations. cited reference experimental by Xie ZL. Current focuses autophagy, cardiomyopathy, oxidative stress, their underlying mechanisms. role reached stable phase development. Future investigations should prioritize mechanistic studies emphasize clinical application novel pharmacological interventions, thereby advancing strategies contributing improved human health outcomes.

Language: Английский