The relationship between sleep duration and frailty: findings from the China Health and Retirement Longitudinal Study DOI Creative Commons
Liyan Huang,

Xiaofang He,

Yao Zuo

et al.

Frontiers in Public Health, Journal Year: 2024, Volume and Issue: 12

Published: Dec. 23, 2024

Background Research investigating the association between sleep duration and risk of frailty has yielded conflicting results. This study used data from China Health Retirement Longitudinal Study (CHARLS) to investigate frailty. Methods Participants aged 45 above at baseline were included in this study. Night or total was categorized into three groups: short (<6 h), normal (6–9 long (≥9 h). Frailty measured by a 31-item index (FI). Non-frail participants followed up after 7-year period. The FI examined linear regression restricted cubic spline (RCS) analysis. relationship evaluated using multinomial logistic Results A 10,258/10,250 (night/total duration) cross-sectional 4,770/4,768 longitudinal negative correlation identified both night (night: β = −0.83, p < 0.001; total: −0.66, 0.001) adjusting for age, sex, education level, marital status, residence, yearly expenditure, BMI, waist circumference, smoking drinking status In study, remained. Short increased 3.59, 3.74, OR [95% confidence interval (CI)], 1.06 [1.05, 1.08], 1.07 [1.06, compared fully adjusted model result remains consistent Conclusion increases Chinese individuals above. Extending population may help prevent alleviate among middle-aged older adult individuals.

Language: Английский

Bidirectional causal associations between frailty measures and sleep disturbances: a two-sample Mendelian randomization study DOI Creative Commons

Lu Che,

Han Zang,

Yaodan Bi

et al.

Nature and Science of Sleep, Journal Year: 2025, Volume and Issue: Volume 17, P. 271 - 284

Published: Feb. 1, 2025

Observational studies have demonstrated a strong association between sleep disturbances and frailty. However, the causality remains inconclusive. We aimed to investigate bidirectional causal relationships frailty measures employing two-sample Mendelian randomization (MR) analysis. Two-sample MR analyses were performed based on large-scale genome-wide (GWAS) of European population for index (FI) (N = 175,226), Fried Frailty Score (FFS) 386,565), insomnia 283,595), duration 445,966) apnea 523,366). conducted estimates using inverse variance-weighted method (IVW), with sensitivity MR-Egger, weighted median, mode, pleiotropy residual sum outlier (MR-PRESSO) Cochran's Q test was assess heterogeneity. found that genetically predicted FI associated shorter apnea. The FFS insomnia, duration, In reverse direction analysis, genetic liability short long an increase in FI. Genetic FFS. Our study provided evidence supporting disturbances. findings contribute prevention management

Language: Английский

Citations

0
Shared genetic architecture and causal relationship between frailty and schizophrenia DOI Creative Commons
Ming‐Gang Deng, Kai Wang, Fang Liu

et al.

Schizophrenia, Journal Year: 2025, Volume and Issue: 11(1)

Published: Feb. 21, 2025

The complex relationship between frailty and schizophrenia has yet to be fully understood. This study aims clarify their by investigating genetic links. We hypothesize a shared architecture bidirectional causal the two conditions. Utilizing summary data from European genome-wide association studies, we analyzed associations through global local correlations, genomic loci, tissue enrichments, functional genes. Bidirectional Mendelian Randomization (MR) was employed infer causality. Our findings show positive correlation (LDSC: rg = 0.117, p 6.686 × 10−7; HDL: 0.101, 5.63 10−13) correlations in three regions (chr9: 94167203-96671698, 2.21 10−6; chr11: 112459488-114257728, 1.01 10−5; chr18: 77149991-78017158, 9.57 10−6). identified 111 loci associated with both conditions demonstrated that variants for share enrichments genes brain. MR analysis suggests increases likelihood of (OR: 1.763, 95% CI: 1.259–2.468, 0.001) vice versa (β: 0.012, 0.006–0.018, < 0.001). research supports presence basis causality schizophrenia. These necessitate further investigation diverse populations confirm expand on this understanding.

Language: Английский

Citations

0
Causality of Childhood and Adult Body Mass Index on Sick Sinus Syndrome: A Mendelian Randomization Study DOI Open Access

Guanzhen Xu,

Zhuang Liu, Ping Hou

et al.

Cureus, Journal Year: 2025, Volume and Issue: unknown

Published: March 20, 2025

Background The relationship between body mass index (BMI) and the risk of sick sinus syndrome (SSS) remains unclear. Clarifying impact BMI on SSS at different life stages is essential for advancing precision medicine implementing effective prevention strategies to reduce burden SSS. Methods causalities childhood adult with were investigated by univariate multivariate Mendelian randomization. Reverse also explored improve accuracy causality findings. Different sources exposure data used replication analysis, effects sample overlap using MRlap. stability results was further enhanced through meta-analysis. Results There a positive correlation in both FinnGen (odds ratio (OR) = 1.17, 95% confidence interval (CI) 1.01-1.35, P 0.031) Integrative Epidemiology Unit (IEU) open genome-wide association study (GWAS) project (OR 1.18, CI 1.04-1.34, 0.009) databases. remained valid after correction telomere length. no detected SSS, as determined independent studies Early Growth Genetics (EGG) 2020 1.06, 0.89-1.27, 0.513) EGG2015 1.02, 0.97-1.09, 0.423). Meta-analysis confirmed reliability causal inference. Conclusions findings indicate that elevated adults, particularly among middle-aged elderly populations, increases developing In contrast, observed suggesting influence susceptibility may predominantly emerge during later stages. These highlight need targeted public health interventions address obesity modifiable factor

Language: Английский

Citations

0
Cross-sectional and longitudinal trajectory analyses of sleep duration and frailty among middle-aged and older Chinese adults DOI Creative Commons
Wei Zheng, Yan Sun, Xianling Liu

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 15, 2025

The relationship between sleep duration and frailty remains unclear, particularly regarding their bidirectional nature temporal dynamics in the Chinese population. This study aimed to investigate cross-sectional association, developmental trajectories, interactions middle-aged older adults. Data were obtained from China Health Retirement Longitudinal Study (CHARLS), which included 12,942 participants for analysis 11,192 longitudinal trajectory study. Latent growth models cross-lagged panel utilized explore effects of on vice versa. Participants' mean age was 59.29 ± 9.48 years, comprising 47.73% men 52.27% women. Cross-sectional revealed that, compared with normal (6-8 h), both Q1 (≤ 5 h, OR = 1.99, 95% CI 1.64-2.41, P < 0.001) Q4 (> 8 1.50, 1.12-2.02, 0.01) showed increased risks frailty. parallel latent model demonstrated that initial level significantly negatively predicted (β - 0.34, 0.001), while rate change 0.61, 0.001). Conversely, 0.36, 0.71, Cross-lagged indicated a causal association frailty, negative predictive effect being relatively stable, had short-term Our U-shaped correlation risk established through investigation. These findings underscore importance balanced patterns early screening conditions

Language: Английский

Citations

0
A cross-sectional study on the relationship between nutrient/food intake and gut microbiota in frailty among older community residents: The Kyotango study DOI Open Access

Yuji Naito,

Takeshi Yasuda, Hiroaki Kitae

et al.

Journal of Clinical Biochemistry and Nutrition, Journal Year: 2024, Volume and Issue: 75(2), P. 161 - 173

Published: Jan. 1, 2024

In strategies to extend a healthy lifespan, early detection and prevention of frailty are critical. The purpose this study was analyze the current state clinical risk factors among community-dwelling older conduct cross-sectional analysis individuals, correlation between nutrient intake, dietary diversity, patterns, elucidate frailty-related gut microbiota. included 786 participants aged ≥65 years from Kyotango Multipurpose Cohort Study who had available data on their Frailty quantitatively assessed by selecting 32 items previously reported index, with those scoring ≥0.21 classified as (

Language: Английский

Citations

1
The relationship between insomnia and multidimensional frailty in community-dwelling older adults: a systematic review DOI
Xiang Qi,

Hui Kong,

Jing Li

et al.

Archives of Gerontology and Geriatrics, Journal Year: 2024, Volume and Issue: 129, P. 105661 - 105661

Published: Oct. 18, 2024

Language: Английский

Citations

1
Short sleep duration as a risk factor for cataract in the elderly hypertensive patients in rural China DOI Creative Commons

Dongbin Yang,

Chen Li, Mingze Ma

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 15, 2024

Abstract Background In an aging society, cataracts continue to significantly impact the quality of life for increasing number elderly individuals. As a risk factor cataract, hypertension is becoming increasingly prevalent among year by year. The association between sleep duration and cataract in hypertensive demographic remains unclear warrants further exploration aid strategizing early intervention programs. Methods Based on China’s National Basic Public Health Service Project (NBPHSP), cross-sectional study was conducted Jia County, Henan Province, China. A total 17473 cases aged 65 years over with were included this study. Sleep obtained through questionnaires information derived from NBPHSP. Three logistic regression models used assess cataract. Subgroup analysis interaction tests performed address heterogeneity. Results average self-reported (6.77 ± 1.80) hours, prevalence 11.9%. adjusted model, patients < 6 hours had higher compared those 7–8 (OR: 1.39, 95%CI: 1.21–1.59). However, non-significant found long findings subgroup indicated no significant effect. Conclusions rural China, less than are at developing cataracts. This finding underscores importance monitoring patterns population. Promoting adequate may be key strategy reducing improving overall hypertension.

Language: Английский

Citations

0
Causal Associations Between Sleep Traits and Low Grip Strength: A Bidirectional Mendelian Randomization Study DOI Creative Commons

Yihong Tai,

H. Wang,

Yinghong Dai

et al.

Nature and Science of Sleep, Journal Year: 2024, Volume and Issue: Volume 16, P. 1699 - 1711

Published: Oct. 1, 2024

Sleep disorders and low grip strength often co-occur clinically are geriatric symptoms that cause significant socioeconomic burden. Previous observational studies have found an association between sleep behaviors strength, but the causal relationship remains unclear.

Language: Английский

Citations

0
Causal Associations Between Sleep Traits and Delirium: A Bidirectional Two-Sample Mendelian Randomization Study DOI Creative Commons
Hao Liu, Zhi Zhang, Yuewen He

et al.

Nature and Science of Sleep, Journal Year: 2024, Volume and Issue: Volume 16, P. 2171 - 2181

Published: Dec. 1, 2024

Numerous studies have identified a correlation between sleep and delirium; however, the causal relationship remains ambiguous. This bidirectional two-sample Mendelian randomization (MR) study was conducted to examine possible relationships traits delirium.

Language: Английский

Citations

0
The relationship between sleep duration and frailty: findings from the China Health and Retirement Longitudinal Study DOI Creative Commons
Liyan Huang,

Xiaofang He,

Yao Zuo

et al.

Frontiers in Public Health, Journal Year: 2024, Volume and Issue: 12

Published: Dec. 23, 2024

Background Research investigating the association between sleep duration and risk of frailty has yielded conflicting results. This study used data from China Health Retirement Longitudinal Study (CHARLS) to investigate frailty. Methods Participants aged 45 above at baseline were included in this study. Night or total was categorized into three groups: short (&lt;6 h), normal (6–9 long (≥9 h). Frailty measured by a 31-item index (FI). Non-frail participants followed up after 7-year period. The FI examined linear regression restricted cubic spline (RCS) analysis. relationship evaluated using multinomial logistic Results A 10,258/10,250 (night/total duration) cross-sectional 4,770/4,768 longitudinal negative correlation identified both night (night: β = −0.83, p &lt; 0.001; total: −0.66, 0.001) adjusting for age, sex, education level, marital status, residence, yearly expenditure, BMI, waist circumference, smoking drinking status In study, remained. Short increased 3.59, 3.74, OR [95% confidence interval (CI)], 1.06 [1.05, 1.08], 1.07 [1.06, compared fully adjusted model result remains consistent Conclusion increases Chinese individuals above. Extending population may help prevent alleviate among middle-aged older adult individuals.

Language: Английский

Citations

0