Association between phthalate exposure and metabolic dysfunction-associated steatotic liver disease (MASLD) – systematic literature review

Environmental Research, Journal Year: 2025, Volume and Issue: unknown, P. 121186 - 121186

Published: Feb. 1, 2025

Language: Английский

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Environmental Pollutants, Occupational Exposures, and Liver Disease

Seminars in Liver Disease, Journal Year: 2025, Volume and Issue: unknown

Published: March 21, 2025

Environmental pollutants significantly impact liver disease development, progression, and outcomes. This review examines the complex relationship between environmental exposures pathology, from malignant conditions like hepatocellular carcinoma to steatotic cholestatic diseases. Key factors include air pollutants, volatile organic compounds, persistent heavy metals, per- polyfluoroalkyl substances. These compounds can act through multiple mechanisms, including endocrine disruption, metabolic perturbation, oxidative stress, direct hepatotoxicity. The of these is often modified by such as sex, diet, genetic predisposition. Recent research has revealed that even low-level certain chemicals affect health, particularly when combined with other risk factors. emergence exposomics a tool promises enhance our understanding how influence disease. Importantly, exposure effects vary demographic socioeconomic factors, highlighting justice concerns. Implementation this knowledge in clinical practice requires new diagnostic approaches, healthcare system adaptations, increased awareness among medical professionals. In conclusion, provides comprehensive examination current evidence linking discusses implications for public health policy.

Language: Английский

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Association of blood cadmium levels with all-cause and cause-specific mortality among adults with non-alcoholic fatty liver disease: a prospective cohort study

Frontiers in Public Health, Journal Year: 2025, Volume and Issue: 13

Published: April 4, 2025

Background Cadmium (Cd) accumulates in the body over time, damaging organs such as liver, kidneys, and brain. Some researchers have suggested that elevated blood Cd levels may contribute to onset progression of nonalcoholic fatty liver disease (NAFLD). However, only a few studies explored relationship between exposure long-term health outcomes patients with NAFLD. This study aimed evaluate predictive value cadmium for mortality risk Methods analyzed data from 13,450 NAFLD National Health Nutrition Examination Survey (NHANES) database, covering years 1999 2018. Patients were categorized into three groups based on their levels. The concentrations all-cause, cardiovascular, cancer was assessed using Cox proportional hazards regression while accounting potential confounders. Results visualized Kaplan–Meier restricted cubic spline (RCS) curves. Stratified analyses performed validation robustness results. After adjusting all covariates, positively associated NAFLD, showing significant linear dose–response relationship. Specifically, each unit increase Log-transformed concentration, all-cause increased by 191% (HR = 2.91, 95% CI: 2.39–3.53); cardiovascular 160% 2.6, 1.80–3.76); 279% 3.79, 2.54–5.65). analysis confirmed these findings. Conclusion Our suggests high Blood adversely affect prognosis Individuals should be aware take preventive measures. Moreover, stricter environmental protection policies necessary reduce exposure.

Language: Английский

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The non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio as a predictor of all cause and cardiovascular mortality in United States adults with NAFLD: a prospective cohort study

BMC Gastroenterology, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 23, 2025

Language: Английский

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