Cross-Sectional Study Evaluating the Role of Autonomic Nervous System Functional Diagnostics in Differentiating Post-Infectious Syndromes: Post-COVID Syndrome, Chronic Fatigue Syndrome, and Lyme Disease DOI Creative Commons
Branislav Milovanović,

Nina Markovic,

Maša Petrović

et al.

Biomedicines, Journal Year: 2025, Volume and Issue: 13(2), P. 356 - 356

Published: Feb. 4, 2025

Background/Objectives: Post-infectious syndromes, including Post-COVID syndrome, Chronic Fatigue Syndrome, and late-stage Lyme disease, are associated with overlapping clinical features autonomic dysfunction. Despite shared symptoms such as fatigue orthostatic intolerance, the underlying pathophysiology specific patterns of dysfunction may differ. This study aimed to evaluate compare nervous system function in these syndromes using multiple diagnostic modalities identify unique characteristics improve differentiation between conditions. Methods: cross-sectional included 758 patients, which were divided into four groups: Syndrome following unrelated COVID-19, disease. Autonomic was assessed cardiovascular reflex tests, Head-Up Tilt Test, beat-to-beat analysis, five-minute electrocardiogram recordings, 24 h Holter monitoring, ambulatory blood pressure monitoring. Statistical analyses compared parameters across groups, focusing on sympathetic parasympathetic Results: The patients disease showed distinct patterns, a higher prevalence hypotension (53.4%) changes heart rate variability during Test suggestive adrenergic failure. Compared other exhibited reduced baroreceptor sensitivity diminished frequency domain stress. Parasympathetic less prevalent group, while syndrome groups more pronounced imbalances. Conclusions: varying degrees types Late-stage is characterized by failure hemodynamic responses, differentiating it from syndromes. functional assessment could aid understanding managing conditions, offering insights for targeted therapeutic interventions.

Language: Английский

Cross-Sectional Study Evaluating the Role of Autonomic Nervous System Functional Diagnostics in Differentiating Post-Infectious Syndromes: Post-COVID Syndrome, Chronic Fatigue Syndrome, and Lyme Disease DOI Creative Commons
Branislav Milovanović,

Nina Markovic,

Maša Petrović

et al.

Biomedicines, Journal Year: 2025, Volume and Issue: 13(2), P. 356 - 356

Published: Feb. 4, 2025

Background/Objectives: Post-infectious syndromes, including Post-COVID syndrome, Chronic Fatigue Syndrome, and late-stage Lyme disease, are associated with overlapping clinical features autonomic dysfunction. Despite shared symptoms such as fatigue orthostatic intolerance, the underlying pathophysiology specific patterns of dysfunction may differ. This study aimed to evaluate compare nervous system function in these syndromes using multiple diagnostic modalities identify unique characteristics improve differentiation between conditions. Methods: cross-sectional included 758 patients, which were divided into four groups: Syndrome following unrelated COVID-19, disease. Autonomic was assessed cardiovascular reflex tests, Head-Up Tilt Test, beat-to-beat analysis, five-minute electrocardiogram recordings, 24 h Holter monitoring, ambulatory blood pressure monitoring. Statistical analyses compared parameters across groups, focusing on sympathetic parasympathetic Results: The patients disease showed distinct patterns, a higher prevalence hypotension (53.4%) changes heart rate variability during Test suggestive adrenergic failure. Compared other exhibited reduced baroreceptor sensitivity diminished frequency domain stress. Parasympathetic less prevalent group, while syndrome groups more pronounced imbalances. Conclusions: varying degrees types Late-stage is characterized by failure hemodynamic responses, differentiating it from syndromes. functional assessment could aid understanding managing conditions, offering insights for targeted therapeutic interventions.

Language: Английский

Citations

0