Future horizons in diabetes: integrating AI and personalized care

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16

Published: March 27, 2025

Diabetes is a global health crisis with rising incidence, mortality, and economic burden. Traditional markers like HbA1c are insufficient for capturing short-term glycemic fluctuations, leading to the need more precise metrics such as Glucose Variability (GV) Time in Range (TIR). Continuous Monitoring (CGM) AI integration offer real-time data analytics personalized treatment plans, enhancing control reducing complications. The combination of transcutaneous auricular vagus nerve stimulation (taVNS) artificial Intelligence (AI) further optimizes glucose regulation addresses comorbidities. Empowering patients through AI-driven self-management community support crucial sustainable improvements. Future horizons diabetes care must focus on overcoming challenges privacy, algorithmic bias, device interoperability, equity while integrating these innovations into healthcare systems improve patient outcomes quality life.

Language: Английский

Genome-Scale Metabolic Modeling of Human Pancreas with Focus on Type 2 Diabetes

OMICS A Journal of Integrative Biology, Journal Year: 2025, Volume and Issue: unknown

Published: March 11, 2025

Type 2 diabetes (T2D) is characterized by relative insulin deficiency due to pancreatic beta cell dysfunction and resistance in different tissues. Not only cells but also other islet (alpha, delta, polypeptide [PP]) are critical for maintaining glucose homeostasis the body. In this overarching context given that a deeper understanding of T2D pathophysiology novel molecular targets much needed, studies integrate experimental computational biology approaches offer veritable prospects innovation. study, we report on single-cell RNA sequencing data integration with generic Human1 model generate context-specific genome-scale metabolic models alpha, beta, PP nondiabetic states and, importantly, at resolution. Moreover, flux balance analysis was performed investigation activities cells. By altering oxygen uptakes networks, documented ways which hypoglycemia, hyperglycemia, hypoxia led changes various cellular subsystems. Reporter metabolite revealed significant transcriptional around several metabolites involved sphingolipid keratan sulfate metabolism alpha cells, fatty acid myoinositol phosphate delta Taken together, leveraging modeling, research bridges gap between theory clinical practice, offering comprehensive framework advance our T2D, contributes new knowledge toward development targeted precision medicine interventions.

Language: Английский

Modified Weiling Decoction inhibited excessive autophagy via AKT/mTOR/ULK1 pathway to alleviate T2DM: Integrating network pharmacology and experimental validation

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 119753 - 119753

Published: April 1, 2025

Language: Английский