Effects and mechanisms of synchronous virtual reality action observation and electrical stimulation on upper extremity motor function and activities of daily living in patients with stroke: a protocol for a randomized controlled trial DOI Creative Commons
Yao Cui, Cong Fang, Ming Zeng

et al.

Frontiers in Neurology, Journal Year: 2025, Volume and Issue: 16

Published: April 4, 2025

Background Existing rehabilitation techniques are not satisfactory in improving motor function after stroke, resulting heavy social burdens. With discovery of mirror neuron system (MNS), action observation (AO) has become a promising strategy to promote learning rehabilitation. Based on MNS theory and virtual reality (VR) technology, we designed an innovative rehabilitative approach: synchronous 360° VR video AO (VRAO) neuromuscular electrical stimulation (NMES). We hypothesized that VRAO+NMES could enhance activation, thus improve upper limb activities daily living stroke survivors. Methods To explore the efficacy mechanism VRAO+NMES, this single center, evaluator blinded, prospective, two arm parallel group randomized controlled trial with 1:1 allocation ratio. The experiment will receive while control landscape combined NMES. Fugl-Meyer Assessment for Upper Extremity is primary outcome study, Brunstrom Recovery Stages Extremity, Manual Muscle Test, Range Motion, Modified Barthel Index, Functional Independence Measure secondary outcomes. In addition, functional near-infrared spectroscopy (fNIRS) surface electromyography (sEMG) be used evaluate activation brain regions related muscles, respectively. Discussion Applying therapy (AOT) popular, another study direction AOT combine it peripheral stimulations simultaneously. Due its full immersive characteristic multi-sensory input, videos based motivation engagement level participants. fNIRS sEMG test results may act as good biomarkers predict outcomes, helping select suitable candidates new intervention. Conclusion provide evidence feasibility potential clinical rehabilitation, applicability generalize use hospital, community, home settings. Clinical registration https://www.chictr.org.cn/showproj.html?proj=178276 , Identifier [ChiCTR2200063552].

Language: Английский

Effects and mechanisms of synchronous virtual reality action observation and electrical stimulation on upper extremity motor function and activities of daily living in patients with stroke: a protocol for a randomized controlled trial DOI Creative Commons
Yao Cui, Cong Fang, Ming Zeng

et al.

Frontiers in Neurology, Journal Year: 2025, Volume and Issue: 16

Published: April 4, 2025

Background Existing rehabilitation techniques are not satisfactory in improving motor function after stroke, resulting heavy social burdens. With discovery of mirror neuron system (MNS), action observation (AO) has become a promising strategy to promote learning rehabilitation. Based on MNS theory and virtual reality (VR) technology, we designed an innovative rehabilitative approach: synchronous 360° VR video AO (VRAO) neuromuscular electrical stimulation (NMES). We hypothesized that VRAO+NMES could enhance activation, thus improve upper limb activities daily living stroke survivors. Methods To explore the efficacy mechanism VRAO+NMES, this single center, evaluator blinded, prospective, two arm parallel group randomized controlled trial with 1:1 allocation ratio. The experiment will receive while control landscape combined NMES. Fugl-Meyer Assessment for Upper Extremity is primary outcome study, Brunstrom Recovery Stages Extremity, Manual Muscle Test, Range Motion, Modified Barthel Index, Functional Independence Measure secondary outcomes. In addition, functional near-infrared spectroscopy (fNIRS) surface electromyography (sEMG) be used evaluate activation brain regions related muscles, respectively. Discussion Applying therapy (AOT) popular, another study direction AOT combine it peripheral stimulations simultaneously. Due its full immersive characteristic multi-sensory input, videos based motivation engagement level participants. fNIRS sEMG test results may act as good biomarkers predict outcomes, helping select suitable candidates new intervention. Conclusion provide evidence feasibility potential clinical rehabilitation, applicability generalize use hospital, community, home settings. Clinical registration https://www.chictr.org.cn/showproj.html?proj=178276 , Identifier [ChiCTR2200063552].

Language: Английский

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