Biomolecules,
Journal Year:
2024,
Volume and Issue:
14(11), P. 1387 - 1387
Published: Oct. 31, 2024
One-carbon
(1C)
metabolism
is
a
complex
network
of
metabolic
reactions
closely
related
to
producing
1C
units
(as
methyl
groups)
and
utilizing
them
for
different
anabolic
processes,
including
nucleotide
synthesis,
methylation,
protein
reductive
metabolism.
These
pathways
support
the
high
proliferative
rate
cancer
cells.
While
drugs
that
target
(like
methotrexate)
have
been
used
treatment,
they
often
significant
side
effects.
Therefore,
developing
new
with
minimal
effects
necessary
effective
treatment.
Methionine,
glycine,
serine
are
main
three
precursors
vital
not
only
cells
but
also
non-proliferative
in
regulating
energy
homeostasis
aging
process.
Understanding
potential
role
crucial
advancing
our
knowledge
neoplastic
progression.
This
review
provides
comprehensive
understanding
molecular
complexities
context
aging,
paving
way
researchers
explore
avenues
advanced
therapeutic
interventions
cancer.
Idiopathic
pulmonary
fibrosis
remains
a
relevant
problem
in
the
field
of
healthcare
with
an
unfavorable
prognosis
for
patients
due
to
progressive
fibrous
remodeling
parenchyma.
Starting
reactions
damaging
epithelial
lining
alveoli,
is
implemented
through
cascade
complex
mechanisms,
crucial
which
TGF-β/SMAD
mediated
pathway,
involving
various
cell
populations.
Considering
that
number
available
drugs
(pirfenidone
and
Nintedanib)
have
only
limited
effectiveness
slowing
progression
fibrosis,
search
justification
application
other
approaches
aimed
at
regulating
immune
response,
cellular
aging
processes,
programmed
death
transdifferentiation
populations
relevant.
This
literature
review
presents
key
modern
concepts
concerning
molecular
genetics
mechanisms
lung
development,
based
mainly
on
vitro
vivo
studies
experimental
models
bleomycin-induced
as
well
latest
data
metabolic
features,
potential
points
effects
vitamin
D
its
metabolites.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(16), P. 8946 - 8946
Published: Aug. 16, 2024
Idiopathic
pulmonary
fibrosis
remains
a
relevant
problem
of
the
healthcare
system
with
an
unfavorable
prognosis
for
patients
due
to
progressive
fibrous
remodeling
parenchyma.
Starting
damage
epithelial
lining
alveoli,
is
implemented
through
cascade
complex
mechanisms,
crucial
which
TGF-β/SMAD-mediated
pathway,
involving
various
cell
populations.
Considering
that
number
available
drugs
(pirfenidone
and
nintedanib)
have
only
limited
effectiveness
in
slowing
progression
fibrosis,
search
justification
new
approaches
aimed
at
regulating
immune
response,
cellular
aging
processes,
programmed
death,
transdifferentiation
populations
relevant.
This
literature
review
presents
key
modern
concepts
concerning
molecular
genetics
mechanisms
lung
development,
based
mainly
on
vitro
vivo
studies
experimental
models
bleomycin-induced
as
well
latest
data
metabolic
features,
potential
targets,
effects
vitamin
D
its
metabolites.
Biomolecules,
Journal Year:
2024,
Volume and Issue:
14(11), P. 1387 - 1387
Published: Oct. 31, 2024
One-carbon
(1C)
metabolism
is
a
complex
network
of
metabolic
reactions
closely
related
to
producing
1C
units
(as
methyl
groups)
and
utilizing
them
for
different
anabolic
processes,
including
nucleotide
synthesis,
methylation,
protein
reductive
metabolism.
These
pathways
support
the
high
proliferative
rate
cancer
cells.
While
drugs
that
target
(like
methotrexate)
have
been
used
treatment,
they
often
significant
side
effects.
Therefore,
developing
new
with
minimal
effects
necessary
effective
treatment.
Methionine,
glycine,
serine
are
main
three
precursors
vital
not
only
cells
but
also
non-proliferative
in
regulating
energy
homeostasis
aging
process.
Understanding
potential
role
crucial
advancing
our
knowledge
neoplastic
progression.
This
review
provides
comprehensive
understanding
molecular
complexities
context
aging,
paving
way
researchers
explore
avenues
advanced
therapeutic
interventions
cancer.
