Hallmarks of Aging: A User’s Guide for Comparative Biologists DOI Creative Commons
Peggy R. Biga, Jingyue Duan, Teresa Young

et al.

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 104, P. 102616 - 102616

Published: Dec. 5, 2024

Since the first description of a set characteristics aging as so-called hallmarks or pillars in 2013/2014, these have served guideposts for research biology. They been examined range contexts, across tissues, response to disease conditions environmental factors, and benchmark various anti-aging interventions. While were intended capture generalizable aging, they are derived mostly from studies rodents humans. Comparative including species animal tree life great promise reveal new insights into mechanistic foundations there is diversity lifespan age-associated physiological changes. However, it unclear how well defined apply diverse species. Here, we review each twelve by Lopez-Otin 2023 with respect availability data We evaluate current methods used assess their potential be adapted comparative studies. Not unexpectedly, find that supporting described restricted humans few model systems no available many clades. Similarly, not all can easily assessed at least half hallmarks, today employed fill this gap knowledge, suggesting prioritized while developed study remaining hallmarks.

Language: Английский

From Molecular Therapies to Lysosomal Transplantation and Targeted Drug Strategies: Present Applications, Limitations, and Future Prospects of Lysosomal Medications DOI Creative Commons
Adel Alhowyan, Gamaleldin I. Harisa

Biomolecules, Journal Year: 2025, Volume and Issue: 15(3), P. 327 - 327

Published: Feb. 24, 2025

Lysosomes are essential intracellular organelles involved in plentiful cellular processes such as cell signaling, metabolism, growth, apoptosis, autophagy, protein processing, and maintaining homeostasis. Their dysfunction is linked to various diseases, including lysosomal storage disorders, inflammation, cancer, cardiovascular neurodegenerative conditions, aging. This review focuses on current emerging therapies for diseases (LDs), small medicines, enzyme replacement therapy (ERT), gene therapy, transplantation, drug targeting (LDT). study was conducted through databases like PubMed, Google Scholar, Science Direct, other research engines. To treat LDs, medicines target the membrane, acidification processes, cathepsins, calcium mTOR, autophagy. Moreover, small-molecule using chaperones, macro-therapies ERT, editing technologies used LDs. Additionally, endosymbiotic artificial lysosomes, transplantation promising options LD management. LDT enhances therapeutic outcomes Extracellular vesicles mannose-6-phosphate-tagged nanocarriers display approaches improving LDT. concluded that lysosomes play a crucial role pathophysiology of numerous diseases. Thus, restoring function treating wide range conditions. Despite offering significant potential control, there ample challenges regarding safety ethical implications.

Language: Английский

Citations

1
Multifunctional Roles and Phytopharmacological Potential of Ursolic Acid: an Invaluable Natural Nutraceutical Agent DOI
Pranay Wal,

Shubhi Kaushal,

Jyotsana Dwivedi

et al.

Russian Journal of Bioorganic Chemistry, Journal Year: 2025, Volume and Issue: 51(1), P. 1 - 34

Published: Feb. 1, 2025

Language: Английский

Citations

0
The emerging role of miRNAs in biological aging and age-related diseases DOI Creative Commons

Rawad Turko,

Amro Hajja,

Ahmad M. Magableh

et al.

Non-coding RNA Research, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Language: Английский

Citations

0
Non-Coding RNAs of Mitochondrial Origin: Roles in Cell Division and Implications in Cancer DOI Open Access
Roberto Piergentili, Stefano Sechi

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(13), P. 7498 - 7498

Published: July 8, 2024

Non-coding RNAs (ncRNAs) are a heterogeneous group, in terms of structure and sequence length, consisting RNA molecules that do not code for proteins. These ncRNAs have central role the regulation gene expression virtually involved every process analyzed, ensuring cellular homeostasis. Although, over years, much research has focused on characterization non-coding transcripts nuclear origin, improved bioinformatic tools next-generation sequencing (NGS) platforms allowed identification hundreds transcribed from mitochondrial genome (mt-ncRNA), including long (lncRNA), circular (circRNA), microRNA (miR). Mt-ncRNAs been described diverse processes such as proteome homeostasis retrograde signaling; however, function majority mt-ncRNAs remains unknown. This review focuses subgroup human whose dysfunction is associated with both failures cell cycle regulation, leading to defects growth, proliferation, apoptosis, development tumor hallmarks, migration metastasis formation, thus contributing carcinogenesis development. Here we provide an overview mt-ncRNAs/cancer relationship could help future new biomedical applications field oncology.

Language: Английский

Citations

3
Common features between aging and cancer: a narrative review DOI
Muhammad Abubakar,

Yasir Hameed,

Muhammad Kiani

et al.

Aging advances., Journal Year: 2024, Volume and Issue: 1(2), P. 118 - 134

Published: Dec. 1, 2024

Aging is a complex biological process characterized by gradual deterioration in physiological activities, contributing to an elevated risk of different age-associated malignancies, including cancer. The current review paper aims elucidate the association between hallmarks aging and parallel development Various cellular molecular mechanisms underlying such as senescence, genomic instability, telomere shortening play significant role accumulation genetic mutations disruption activities. It has also discussed immune system’s aging, indicating how age-linked dysfunction compromises body’s capacity recognize eradicate pre-tumorous cells, thus promoting cancer advancement. This examines affects tumor microenvironment, where age-related alterations stromal extracellular matrix factors lead conditions that promote growth proliferation. Furthermore, it discusses concept “accelerated aging” survivors, highlighting negative effects its therapy intensify process, resulting greater physical cognitive decline. explores prospect new therapies target aging-related processes ameliorate outcomes. Overall, underscores need for ongoing interdisciplinary research understand relationship cancer, ultimately aiming develop more effective prevention treatment approaches.

Language: Английский

Citations

3
Hallmarks of Aging: A User’s Guide for Comparative Biologists DOI Creative Commons
Peggy R. Biga, Jingyue Duan, Teresa Young

et al.

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 104, P. 102616 - 102616

Published: Dec. 5, 2024

Since the first description of a set characteristics aging as so-called hallmarks or pillars in 2013/2014, these have served guideposts for research biology. They been examined range contexts, across tissues, response to disease conditions environmental factors, and benchmark various anti-aging interventions. While were intended capture generalizable aging, they are derived mostly from studies rodents humans. Comparative including species animal tree life great promise reveal new insights into mechanistic foundations there is diversity lifespan age-associated physiological changes. However, it unclear how well defined apply diverse species. Here, we review each twelve by Lopez-Otin 2023 with respect availability data We evaluate current methods used assess their potential be adapted comparative studies. Not unexpectedly, find that supporting described restricted humans few model systems no available many clades. Similarly, not all can easily assessed at least half hallmarks, today employed fill this gap knowledge, suggesting prioritized while developed study remaining hallmarks.

Language: Английский

Citations

2