Curcumin: A Golden Approach to Healthy Aging: A Systematic Review of the Evidence

Nutrients, Journal Year: 2024, Volume and Issue: 16(16), P. 2721 - 2721

Published: Aug. 15, 2024

Aging-related disorders pose significant challenges due to their complex interplay of physiological and metabolic factors, including inflammation, oxidative stress, mitochondrial dysfunction. Curcumin, a natural compound with potent antioxidant anti-inflammatory properties, has emerged as promising candidate for mitigating these age-related processes. However, gaps in understanding the precise mechanisms curcumin’s effects optimal dosages different conditions necessitate further investigation. This systematic review synthesizes current evidence on potential addressing disorders, emphasizing its impact cognitive function, neurodegeneration, muscle health older adults. By evaluating safety, efficacy, action curcumin supplementation, this aims provide insights into therapeutic promoting healthy aging. A search across three databases using specific keywords yielded 2256 documents, leading selection 15 clinical trials synthesis. Here, we highlight multifaceted agent combating disorders. The findings suggest that could offer effective approach enhancing quality life aging individuals. Further research well-designed are essential validate optimize use personalized medicine approaches conditions.

Language: Английский

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The connection between 91 inflammatory cytokines and frailty mediated by 1400 metabolites: An exploratory two-step Mendelian randomization analysis

Archives of Gerontology and Geriatrics, Journal Year: 2025, Volume and Issue: 133, P. 105774 - 105774

Published: Feb. 25, 2025

Language: Английский

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Aging and Pathological Conditions Similarity Revealed by Meta-Analysis of Metabolomics Studies Suggests the Existence of the Health and Age-Related Metapathway

Metabolites, Journal Year: 2024, Volume and Issue: 14(11), P. 593 - 593

Published: Nov. 4, 2024

: The incidence of many diseases increases with age and leads to multimorbidity, characterized by the presence multiple in old age. This phenomenon is closely related systemic metabolic changes; most suitable way study it through metabolomics. use accumulated metabolomic data characterize this at system level may provide additional insight into nature strength aging-disease relationships.

Language: Английский

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Identification of Oxidative Stress-Related Genes in Hyperlipidemia Based on Bioinformatic Analysis

Molecular Biotechnology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 5, 2024

Language: Английский

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