Dysbiosis of Oral Microbiome: A Key Player in Oral Carcinogenesis? A Critical Review
Biomedicines,
Journal Year:
2025,
Volume and Issue:
13(2), P. 448 - 448
Published: Feb. 12, 2025
The
oral
cavity
is
known
to
harbor
hundreds
of
microorganisms,
belonging
various
genera,
constituting
a
peculiar
flora
called
the
microbiome.
change
in
relative
distribution
constituents
this
microbial
flora,
due
any
reason,
leads
dysbiosis.
For
centuries,
dysbiosis
has
been
linked
etiopathogenesis
several
medical
illnesses,
both
locally
and
systemically-.
However,
aided
by
recent
advent
bio-technological
capabilities,
reports
have
re-emerged
that
link
carcinogenesis,
numerous
studies
are
currently
exploring
their
association
plausible
mechanisms.
Some
proposed
mechanisms
dysbiosis-induced
carcinogenesis
(ODIC)
include—a
bacteria-induced
chronic
inflammatory
state
leading
direct
cellular
damage,
inflammatory-cytokine-mediated
promotion
proliferation
invasion,
release
bacterial
products
carcinogenic,
suppression
local
immunity
alteration
tumor
microenvironment.
actual
interactions
between
these
role
not
yet
fully
understood.
This
review
provides
comprehensive
overview
hypotheses
implicated
ODIC,
along
with
corresponding
molecular
aberrations.
Apart
from
discussing
usual
microbiome
profile,
also
summarizes
profiles
ODIC.
sheds
light
on
potential
clinical
implications
research
prevention
management
cancer.
Language: Английский
ANALYSIS OF THE PREVALENCE AND STRUCTURE OF PERIODONTAL TISSUE DISEASES AMONG ELDERLY PEOPLE IN THE RIVNE REGION
Ukrainian Dental Almanac,
Journal Year:
2024,
Volume and Issue:
4, P. 28 - 32
Published: Dec. 25, 2024
The
article
presents
the
results
of
a
survey
elderly
residents
in
Rivne
region
to
determine
prevalence
periodontal
diseases.
Objective.
To
analyze
and
structure
tissue
diseases
among
patients
region.
Materials
methods.
A
total
500
individuals
aged
60
75
were
examined
divided
into
three
age
groups:
group
I
included
183
60-64,
II
consisted
153
65-69,
III
164
70-75.
All
participants
underwent
clinical
radiological
examinations,
diagnosis
was
established.
For
each
group,
various
determined,
indicators
analyzed
separately
by
gender.
Results
discussion.
According
results,
lesions
diagnosed
449
(89.8%),
while
only
51
(10.2%)
had
intact
periodontium.
higher
males,
with
236
men
(93.7%)
213
women
(85.9%)
affected.
Generalized
periodontitis
most
common
condition
disease
structure,
308
(68.6%),
followed
periodontosis
111
cases
(24.7%),
chronic
catarrhal
gingivitis
20
(4.5%),
localized
10
(2.2%).
Conclusions.
is
89.6%,
advanced
stages
increasing
older
groups.
are
predominant
structure.
Language: Английский