Epigenetic Echoes: Bridging Nature, Nurture, and Healing Across Generations

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 3075 - 3075

Published: March 27, 2025

Trauma can impact individuals within a generation (intragenerational) and future generations (transgenerational) through complex interplay of biological environmental factors. This review explores the epigenetic mechanisms that have been correlated with effects trauma across generations, including DNA methylation, histone modifications, non-coding RNAs. These regulate expression stress-related genes (such as glucocorticoid receptor (NR3C1) FK506 binding protein 5 (FKBP5) gene), linking to pathways may affect long-term stress regulation health outcomes. Although research using model organisms has elucidated potential underlying intergenerational trauma, applying these findings human populations remains challenging due confounding variables, methodological limitations, ethical considerations. complexity is compounded by difficulties in establishing causality disentangling influences from shared Emerging therapies, such psychedelic-assisted treatments mind-body interventions, offer promising avenues address both psychological aspects trauma. However, translating into effective interventions will require interdisciplinary methods culturally sensitive approaches. Enriched environments, cultural reconnection, psychosocial shown mitigate trauma's impacts generations. By integrating biological, social, perspectives, this highlights critical importance frameworks breaking cycles fostering resilience, advancing comprehensive healing

Language: Английский

Biology, Genetics and Molecular Aspects of Aging

IGI Global eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 67 - 94

Published: April 25, 2025

Aging is a complicated process influenced by various factors that disturb cellular function and alter organism equilibrium over time. This chapter provides an updated overview, focusing on mechanisms like genomic instability, telomere attrition, mitochondrial failure, DNA damage buildup. Cellular senescence addressed in age-related illnesses, highlighting irreversible cell cycle arrest pro-inflammatory aspects. Epigenetic processes, specifically methylation inherited histone modifications, contribute to phenotypes. Longevity research covers FOXO, SIRT, autophagy. Nutrient-sensing pathways the microbiome's role aging are explored, along with therapeutic interventions targeting these pathways. synthesis of recent discoveries genetics, molecular biology, translational comprehensive perspective biology future clinical applications. By integrating insights from fields, this aims develop innovative strategies promote healthy longevity.

Language: Английский