Epigenetic Echoes: Bridging Nature, Nurture, and Healing Across Generations
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(7), P. 3075 - 3075
Published: March 27, 2025
Trauma
can
impact
individuals
within
a
generation
(intragenerational)
and
future
generations
(transgenerational)
through
complex
interplay
of
biological
environmental
factors.
This
review
explores
the
epigenetic
mechanisms
that
have
been
correlated
with
effects
trauma
across
generations,
including
DNA
methylation,
histone
modifications,
non-coding
RNAs.
These
regulate
expression
stress-related
genes
(such
as
glucocorticoid
receptor
(NR3C1)
FK506
binding
protein
5
(FKBP5)
gene),
linking
to
pathways
may
affect
long-term
stress
regulation
health
outcomes.
Although
research
using
model
organisms
has
elucidated
potential
underlying
intergenerational
trauma,
applying
these
findings
human
populations
remains
challenging
due
confounding
variables,
methodological
limitations,
ethical
considerations.
complexity
is
compounded
by
difficulties
in
establishing
causality
disentangling
influences
from
shared
Emerging
therapies,
such
psychedelic-assisted
treatments
mind-body
interventions,
offer
promising
avenues
address
both
psychological
aspects
trauma.
However,
translating
into
effective
interventions
will
require
interdisciplinary
methods
culturally
sensitive
approaches.
Enriched
environments,
cultural
reconnection,
psychosocial
shown
mitigate
trauma's
impacts
generations.
By
integrating
biological,
social,
perspectives,
this
highlights
critical
importance
frameworks
breaking
cycles
fostering
resilience,
advancing
comprehensive
healing
Language: Английский
Biology, Genetics and Molecular Aspects of Aging
Elakkiya Maruthamuthu Rathinam,
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K M Mohandas,
No information about this author
Tharani Sureshkumar
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et al.
IGI Global eBooks,
Journal Year:
2025,
Volume and Issue:
unknown, P. 67 - 94
Published: April 25, 2025
Aging
is
a
complicated
process
influenced
by
various
factors
that
disturb
cellular
function
and
alter
organism
equilibrium
over
time.
This
chapter
provides
an
updated
overview,
focusing
on
mechanisms
like
genomic
instability,
telomere
attrition,
mitochondrial
failure,
DNA
damage
buildup.
Cellular
senescence
addressed
in
age-related
illnesses,
highlighting
irreversible
cell
cycle
arrest
pro-inflammatory
aspects.
Epigenetic
processes,
specifically
methylation
inherited
histone
modifications,
contribute
to
phenotypes.
Longevity
research
covers
FOXO,
SIRT,
autophagy.
Nutrient-sensing
pathways
the
microbiome's
role
aging
are
explored,
along
with
therapeutic
interventions
targeting
these
pathways.
synthesis
of
recent
discoveries
genetics,
molecular
biology,
translational
comprehensive
perspective
biology
future
clinical
applications.
By
integrating
insights
from
fields,
this
aims
develop
innovative
strategies
promote
healthy
longevity.
Language: Английский