Dual-action approach to oral cancer therapy: integrating HDAC inhibition and photodynamic therapy with LXD191

Lasers in Medical Science, Journal Year: 2025, Volume and Issue: 40(1)

Published: Feb. 17, 2025

Language: Английский

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Illuminating the path: the role of photodynamic therapy in comprehensive periodontal treatment

Irish Journal of Medical Science (1971 -), Journal Year: 2025, Volume and Issue: unknown

Published: March 3, 2025

Language: Английский

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Photosensitized Methylene Blue Nanoparticles: A Promising Approach for the Control of Oral Infections

Biomedicines, Journal Year: 2025, Volume and Issue: 13(3), P. 673 - 673

Published: March 10, 2025

Introduction: Oral infections pose significant public health challenges, often exacerbating other comorbidities and increasing systemic risks. Traditional treatments fail to eliminate persistent micro-organisms contribute the rise of antimicrobial resistance. Nanoparticulate systems offer a promising solution by delivering active agents directly targeted sites, providing more effective localized treatment options. Objective: This study aimed synthesize characterize methylcellulose nanoparticles containing methylene blue at different concentrations using nanoprecipitation method. We also evaluated their biocompatibility activity against key commonly found in oral infections. Methods: The involved physicochemical morphological characterizations, including encapsulation efficiency, particle size, polydispersity index, zeta potential, transmission electron microscopy (TEM). Additionally, controlled release profiles, efficacy major pathogens, vitro assessments were performed. Results: results revealed efficiency between 99.1 98.8%, with sizes ranging from 186 274 nm potential 1.7 2.9 mV achieved lower methylcellulose. demonstrated sustained drug 85% for smaller particles 45% larger than 10 h. exhibited superior compared pure blue. Cell viability studies indicated that biocompatible approximately 40% cell nanoparticles. Conclusions: These findings suggest could serve as adjunct dental treatments. They action while potentially reducing development

Language: Английский

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Adhesive two-dimensional bimetallic organic framework nanozymes for regulating inflammation and eradicating bacteria in periodontal disease

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 164263 - 164263

Published: May 1, 2025

Language: Английский

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