Annual Review of Virology,
Journal Year:
2023,
Volume and Issue:
10(1), P. 503 - 524
Published: June 2, 2023
The
global
rise
of
antibiotic
resistance
in
bacterial
pathogens
and
the
waning
efficacy
antibiotics
urge
consideration
alternative
antimicrobial
strategies.
Phage
therapy
is
a
classic
approach
where
bacteriophages
(bacteria-specific
viruses)
are
used
against
infections,
with
many
recent
successes
personalized
medicine
treatment
intractable
infections.
However,
perpetual
challenge
for
developing
generalized
phage
expectation
that
viruses
will
exert
selection
target
bacteria
to
deploy
defenses
virus
attack,
causing
evolution
during
patient
treatment.
Here
we
review
two
main
complementary
strategies
mitigating
therapy:
minimizing
ability
populations
evolve
driving
(steering)
phage-resistant
toward
clinically
favorable
outcomes.
We
discuss
future
research
directions
might
further
address
phage-resistance
problem,
foster
widespread
development
deployment
therapeutic
outsmart
evolved
clinical
settings.
Frontiers in Physiology,
Journal Year:
2025,
Volume and Issue:
16
Published: April 24, 2025
Although
evolutionary
medicine
has
produced
several
novel
insights
for
explaining
prevalent
health
issues,
it
yet
to
sufficiently
address
possible
adverse
mental
effects
of
humans
during
long-term
space
missions
While
applications
have
increased
over
the
past
20
years,
there
is
scope
integration
in
new
branch
called
bioastronautics,
which
analyses
on
human
bodies
when
outer
space.
Evolutionary
principles
may
explain
what
kinds
environments
increase
risks
astronauts,
both
short
and
long
term;
secondly,
provide
a
more
informed
understanding
mismatch
between
terrestrial
astronauts
exist.
This
information
assist
developing
frameworks
improving
future
colonists.
Consequently,
this
paper
will
focus
some
major
mismatches
currently
confronting
astronauts’
health,
with
an
aim
improve
medical
knowledge.
It
also
therapeutic
countermeasures
based
reducing
astronauts.
Global Sustainability,
Journal Year:
2024,
Volume and Issue:
7
Published: Jan. 1, 2024
Abstract
Non-technical
summary
Evolutionary
biology
considers
how
organisms
and
populations
change
over
multiple
generations,
so
is
naturally
focused
on
issues
of
sustainability
through
time.
Yet,
science
rarely
incorporates
evolutionary
thinking
most
scientists
policy
makers
do
not
account
for
processes
contribute
to
sustainability.
Understanding
the
interplay
between
nature's
contribution
people
key
sustaining
life
Earth.
Technical
Evolution,
in
gene
frequencies
within
populations,
a
process
genetically
based
modification
by
descent,
providing
raw
material
essential
adaptation
environmental
change.
Therefore,
it
crucial
that
we
understand
if
aim
sustainable
planet.
We
here
this
development
describing
examples
contemporary,
rapid
changes
concern
sustainability,
specifically
highlighting
global
spread
severe
acute
respiratory
syndrome
coronavirus-2
(SARS-CoV-2)
toolbox
allowed
tracking
origins
evolution
SARS-CoV-2
real
time
predicting
potential
future
outbreaks.
also
consider
urban
accelerates
such
as
altered
phenotypic
physiological
infectious
zoonotic
diseases.
show
importance
concepts
techniques
public-health
decision
making.
Many
insights
contributing
challenges
exist,
including
diseases,
ecosystem
human
health,
conservation
natural
resources.
thus
join
recent
calls
advocating
stronger
collaboration
biologists
community,
increasing
interdisciplinarity
awareness
about
knowledge
making
policies.
Social
media
Evolution
fundamental
Earth
should
be
incorporated
measures
PLoS ONE,
Journal Year:
2024,
Volume and Issue:
19(4), P. e0300962 - e0300962
Published: April 4, 2024
While
extensive
research
on
traditional
model
species
has
significantly
advanced
the
biological
sciences,
ongoing
search
for
new
organisms
is
essential
to
tackle
contemporary
challenges
such
as
human
diseases
or
climate
change,
and
fundamental
phenomena
including
adaptation
speciation.
Recent
methodological
advances
next-generation
sequencing,
gene
editing,
imaging
are
widely
applicable
have
simplified
selection
of
with
specific
traits
from
wild.
However,
a
critical
milestone
in
this
endeavor
remains
successful
cultivation
selected
species.
A
historically
overlooked
but
increasingly
recognized
group
non-model
cave
dwellers.
These
unique
animals
offer
invaluable
insights
into
genetic
basis
like
eye
degeneration,
metabolic
neurological
disorders,
basic
evolutionary
principles
origin
adaptive
phenotypes.
take
advantage
beneficial
cave-dwelling
animals,
laboratory
cultures
must
be
established—a
practice
that
extremely
rare
except
cavefish
Astyanax
mexicanus
.
For
most
organisms,
there
no
published
culturing
protocols.
In
study,
we
present
results
our
multi-year
effort
establish
variety
invertebrate
groups.
We
developed
comprehensive
protocols
housing,
feeding,
husbandry
dwellers
their
surface
relatives.
Our
recommendations
versatile
can
applied
wide
range
Hopefully
efforts
will
facilitate
establishment
animal
facilities
encourage
greater
use
experimental
biology.
Dynamic Games and Applications,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 14, 2024
Abstract
We
present
a
game-theoretic
model
of
polymorphic
cancer
cell
population
where
the
treatment-induced
resistance
is
quantitative
evolving
trait.
When
stabilization
tumor
burden
possible,
we
expand
into
Stackelberg
evolutionary
game,
physician
leader
and
cells
are
followers.
The
chooses
treatment
dose
to
maximize
an
objective
function
that
proxy
patient’s
quality
life.
In
response,
evolve
level
maximizes
their
proliferation
survival.
Assuming
in
its
ecological
equilibrium,
compare
outcomes
three
different
strategies:
giving
maximum
tolerable
throughout,
corresponding
standard
care
for
most
metastatic
cancers,
ecologically
enlightened
therapy,
anticipates
short-run,
response
treatment,
but
not
evolution
evolutionarily
both
consequences
treatment.
Of
therapeutic
strategies,
therapy
leads
highest
values
function,
lowest
dose,
resistance.
Conversely,
our
model,
worst
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(20), P. 11212 - 11212
Published: Oct. 18, 2024
To
maintain
its
development,
the
growing
fetus
is
directly
dependent
on
placenta,
an
organ
that
acts
as
both
a
modulator
and
mediator.
As
essential
component
of
pregnancy
derived
from
maternal
fetal
tissues,
placenta
facilitates
passage
all
oxygen
nutrients
expecting
parent
to
their
fetuses.
Further,
conveys
multiple
impacts
environment
fetus.
The
timing
placental
development
parallels
cardiovascular
system,
anomalies
are
implicated
potential
cause
congenital
heart
disease.
For
example,
disease
more
common
in
pregnancies
complicated
by
preeclampsia,
condition
characterized
dysfunction.
Given
placenta’s
intermediary
links
health
outcomes,
it
emerging
focus
evolutionary
medicine,
which
seeks
understand
how
interactions
between
humans
affect
our
biology
give
rise
present
review
provides
overview
developmental
courses
well
implications
infant
health.
