Non-Linear Biomechanical Evaluation and Comparison in the Assessment of Three Different Piece Dental Implant Systems for the Molar Region: A Finite Element Study

Journal of Functional Biomaterials, Journal Year: 2025, Volume and Issue: 16(1), P. 17 - 17

Published: Jan. 9, 2025

The widely available options of different manufacturers in dental implant systems have complicated the selection criteria process for periodontists, necessitating careful consideration various factors when selecting suitable solutions individual patient needs. Optimal requires patient-specific factors, design, and surgical technique. Understanding biomechanical behavior implant-tissue interactions is crucial achieving successful long-lasting therapy. To adequately address this issue improve rigorous from a biomechanically numerical approach, research aims to analyze stress distribution fields, strain patterns, load transfer displacements within system implant-biological interface (gingival bony tissues) titanium three-piece two-one-piece ceramic systems. Thus, three commercially implants designed be placed jaw molar region were considered evaluation through finite element method under both oblique occlusal loading conditions. results exhibited an increasing trend highlight outstanding two-piece dissipate better (6 2 times lower than three- one-piece loads almost 5 1.3 more efficient loading, respectively), minimize peak values (below 100 MPa), reduce patterns compared with other two evaluated designs. On hand, effects generated biological tissues are strongly associated geometry features. This approach could provide promising strategy predicting micro-strains micromotion pieces geometries. Hence, these findings contribute deeper understanding biomechanics spectrum emphasize importance carefully appropriate material accurate performance.

Language: Английский

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Localized Growth Factor Delivery from Microparticles Modulates Osteogenic and Chondrogenic Gene Expression in a Growth Factor-Dependent Manner in an ex vivo Chick Embryonic Bone Model

Published: Jan. 1, 2025

Language: Английский

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Advances in computational modeling of cytokine and growth factor dynamics in bone healing: a scoping review

Biomechanics and Modeling in Mechanobiology, Journal Year: 2025, Volume and Issue: unknown

Published: March 14, 2025

Language: Английский

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Smart nanomaterials for multimodal theranostics and tissue regeneration

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 541, P. 216801 - 216801

Published: May 17, 2025

Language: Английский

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Palm Tocotrienol Preserves Trabecular Osteocyte Indices and Modulates the Expression of Osteocyte Markers in Ovariectomized Rats

Biomedicines, Journal Year: 2025, Volume and Issue: 13(5), P. 1220 - 1220

Published: May 18, 2025

Background/Objective: Palm tocotrienol has bone-protective properties in animal models, yet its underlying mechanism remains unclear. Given osteocytes’ role bone homeostasis, this research aimed to investigate the effects of palm on quantity osteocytes and expression osteocyte-specific markers ovariectomized rats. Methods: Adult female rats (Sprague Dawley; three-month-old; n = 6/group) were randomly divided into baseline, sham control, unemulsified (UPT), emulsified (EPT), positive control. The baseline group was euthanized without intervention, whereas underwent a laparotomy procedure which ovaries not excised. other groups bilateral removal subsequently received UPT (100 mg/kg/day, 50% vitamin E), EPT 25% or combination glucosamine sulfate (250 mg/kg/day) calcium carbonate (1% drinking water). Control induced with similar gavage stress olive oil. After 10 weeks, all sacrificed for serum analysis. Results: significantly increased trabecular osteocyte total lacunae numbers (p < 0.05 versus control). Both treatments reduced mRNA levels dentin matrix protein-1 control), sclerostin unchanged > However, neither nor improved circulating skeletal redox status Conclusions: may support health by preserving modulating osteocyte-mediated remodeling. Further is required elucidate precise mechanisms.

Language: Английский

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A mathematical model of glomerular fibrosis in diabetic kidney disease to predict therapeutic efficacy

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 25, 2024

Glomerular fibrosis is a tissue damage that occurs within the kidneys of chronic and diabetic kidney disease patients. Effective treatments are lacking, mechanism glomerular reversal poorly understood. A mathematical model suitable for hypothesis-driven systems pharmacology in diabetes was developed from previous interstitial fibrosis. The adapted consists system ordinary differential equations models complex etiology progression diabetes. Within scope incorporated, advanced glycation end products (AGE)-matrix proteins modified due to high blood glucose-were identified as major contributors delay recovery after glucose control. predicted inhibition AGE production not an effective approach accelerating Further, treatment breaking down accumulated most productive at reversing use led identification control aminoguanidine ineffective because they do remove AGE. Additionally, using model, potential explanation generated lack efficacy alagebrium treating fibrosis, which inability reduce TGF- β . Using mechanistic understanding complexity illuminated, then explanations different pharmacological agents were provided. This can enable development more efficacious therapeutics

Language: Английский

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A Mathematical Model of Glomerular Fibrosis in Diabetic Kidney Disease to Predict Therapeutic Efficacy

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: April 4, 2023

1 ABSTRACT Background Glomerular fibrosis is a tissue damage that occurs within the kidneys of chronic and diabetic kidney disease patients. Effective treatments are lacking, mechanism glomerular reversal poorly understood. Method A mathematical model suitable for hypothesis-driven systems pharmacology in diabetes was developed from previous interstitial fibrosis. The adapted consists system ordinary differential equations models complex etiology progression diabetes. Results Within scope incorporated, advanced glycation end products (AGE)—matrix proteins modified due to high blood glucose—were identified as major contributors delay recovery after glucose control. predicted inhibition AGE production not an effective approach accelerating Further, breaking down accumulated most productive at reversing use led identification control aminoguanidine ineffective because they do remove AGE. Additionally, using model, potential explanation generated lack efficacy alagebrium treating fibrosis, which inability reduce TGF-β. Impact Using mechanistic understanding complexity illuminated, then explanations different pharmacological agents were provided. This can enable development more efficacious therapeutics

Language: Английский

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Part II: A new perspective for modeling the bone remodeling process: Biology, mechanics, and pathologies

Journal of Theoretical Biology, Journal Year: 2024, Volume and Issue: 593, P. 111894 - 111894

Published: July 9, 2024

Language: Английский

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