Integrated approaches for immunotoxicity risk assessment: challenges and future directions

Deleted Journal, Journal Year: 2024, Volume and Issue: 1(1)

Published: Oct. 29, 2024

The integration of immunotoxicity data into chemical risk assessment paradigms is essential for comprehensively evaluating the potential health hazards posed by exposures. This review provides a comprehensive overview methodologies, challenges, and future directions integrating frameworks. It discusses fundamental principles immunotoxicology its relevance to assessment, highlighting critical roles immune system in defense against harmful agents. Next, we explore traditional frameworks, including exposure hazard identification, dose–response characterization, need incorporating endpoints enhance characterization estimation. Subsequently, delve modelling immunotoxicity, elucidating principles, methods, case studies illustrating relationships extrapolation from animal humans. Furthermore, discuss focusing on identification immunotoxic hazards, evaluation endpoints, utilization immunological biomarkers assessment. We then examine cumulative strategies, presenting conceptual framework assessing risks multiple exposures methods different chemicals. Lastly, emerging trends high-throughput screening assays, omics technologies, computational modelling, alternative testing along with regulatory implications research needs. valuable insights researchers, regulators, stakeholders involved public protection, facilitating development evidence-based strategies safeguarding human associated

Language: Английский

Lysosome toxicities induced by nanoparticle exposure and related mechanisms

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 286, P. 117215 - 117215

Published: Oct. 19, 2024

Language: Английский