The Role of Genetic Variation in Shaping Phenotypic Responses to Diet in AgingDrosophila melanogaster DOI Creative Commons
Nikolaj Bak, Trudy F. C. Mackay, Fabio Morgante

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 14, 2025

Nutrition plays a central role in healthy living, however, extensive variability individual responses to dietary interventions complicates our understanding of its effects. Here we present comprehensive study utilizing the Drosophila Genetic Reference Panel (DGRP), investigating how genetic variation influences diet and aging. Quantitative analyses impact restriction on lifespan, locomotor activity, dry weight, heat knockdown time were performed. Locomotor weight measured same flies. We found significant genotype-by-diet interaction (GDI) genotype-by-age (GAI) for all traits. Therefore, environmental factors play crucial shaping trait at different ages diets, and/or distinct these traits diets. Our genome wide association also identified quantitative locus age-dependent response. The observed GDI GAI indicates that susceptibility changes as organisms age, which could have implications recommendations aimed promoting aging humans. identification associations between DNA sequence opens new avenues research into mechanisms underlying interactions.

Language: Английский

The Role of Genetic Variation in Shaping Phenotypic Responses to Diet in AgingDrosophila melanogaster DOI Creative Commons
Nikolaj Bak, Trudy F. C. Mackay, Fabio Morgante

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 14, 2025

Nutrition plays a central role in healthy living, however, extensive variability individual responses to dietary interventions complicates our understanding of its effects. Here we present comprehensive study utilizing the Drosophila Genetic Reference Panel (DGRP), investigating how genetic variation influences diet and aging. Quantitative analyses impact restriction on lifespan, locomotor activity, dry weight, heat knockdown time were performed. Locomotor weight measured same flies. We found significant genotype-by-diet interaction (GDI) genotype-by-age (GAI) for all traits. Therefore, environmental factors play crucial shaping trait at different ages diets, and/or distinct these traits diets. Our genome wide association also identified quantitative locus age-dependent response. The observed GDI GAI indicates that susceptibility changes as organisms age, which could have implications recommendations aimed promoting aging humans. identification associations between DNA sequence opens new avenues research into mechanisms underlying interactions.

Language: Английский

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