Comparison of various methodological approaches to model asbestos thresholds for mesothelioma DOI Creative Commons
Julie E. Goodman, Andrey Korchevskiy, Ann G. Wylie

et al.

Frontiers in Public Health, Journal Year: 2025, Volume and Issue: 13

Published: May 13, 2025

Background There is evidence to support several modes of action (MoAs), and particularly non-genotoxic MoAs, for mesothelioma induced by asbestiform elongate mineral particles (EMPs). In turn, these MoAs provide biological dose-response relationships that are non-linear include a threshold. However, statistical models human data have not adequately addressed threshold EMPs mesothelioma. addition, unlike other carcinogens, uniform materials display range properties. Objectives Our objective was review various approaches applying Materials methods We collected from sources, including the Surveillance, Epidemiology, End Results (SEER) Program published case-control studies, cohort meta-analysis evaluated types asbestos risk. Several threshold-based were fit available data. also thresholds certain fiber characteristics. Certain characteristics EMPs, such as width, length, surface area, likely Theoretical based on epidemiology supported thresholds. A Monte Carlo evaluation hypothesis in occupational exposures types, using cumulative exposure metric, demonstrated likelihood be 72% non-textile chrysotile, 80.9% textile 84% amosite, 60% crocidolite. multi-stage clonal expansion (MSCE) model applied SEER registry good with inclusion surrogate predictor amphiboles. Finally, lung burden studies preliminary estimate central-tendency level chrysotile ~90 f/cc-years. Based our proposed approach, we suggest 1.04 f/cc-years 0.25 crocidolite, 4.3–10.9 tremolite. Future should conducted estimates. Conclusions While uncertainties remain, many angles scientific existence mineral-specific

Language: Английский

Comparison of various methodological approaches to model asbestos thresholds for mesothelioma DOI Creative Commons
Julie E. Goodman, Andrey Korchevskiy, Ann G. Wylie

et al.

Frontiers in Public Health, Journal Year: 2025, Volume and Issue: 13

Published: May 13, 2025

Background There is evidence to support several modes of action (MoAs), and particularly non-genotoxic MoAs, for mesothelioma induced by asbestiform elongate mineral particles (EMPs). In turn, these MoAs provide biological dose-response relationships that are non-linear include a threshold. However, statistical models human data have not adequately addressed threshold EMPs mesothelioma. addition, unlike other carcinogens, uniform materials display range properties. Objectives Our objective was review various approaches applying Materials methods We collected from sources, including the Surveillance, Epidemiology, End Results (SEER) Program published case-control studies, cohort meta-analysis evaluated types asbestos risk. Several threshold-based were fit available data. also thresholds certain fiber characteristics. Certain characteristics EMPs, such as width, length, surface area, likely Theoretical based on epidemiology supported thresholds. A Monte Carlo evaluation hypothesis in occupational exposures types, using cumulative exposure metric, demonstrated likelihood be 72% non-textile chrysotile, 80.9% textile 84% amosite, 60% crocidolite. multi-stage clonal expansion (MSCE) model applied SEER registry good with inclusion surrogate predictor amphiboles. Finally, lung burden studies preliminary estimate central-tendency level chrysotile ~90 f/cc-years. Based our proposed approach, we suggest 1.04 f/cc-years 0.25 crocidolite, 4.3–10.9 tremolite. Future should conducted estimates. Conclusions While uncertainties remain, many angles scientific existence mineral-specific

Language: Английский

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