PubMed,
Journal Year:
2021,
Volume and Issue:
2(1), P. 63 - 79
Published: Jan. 1, 2021
The
outbreak
of
severe
acute
respiratory
syndrome-coronavirus-2
(SARS-CoV-2)
has
led
to
coronavirus
disease-19
(COVID-19);
a
pandemic
disease
that
resulted
in
devastating
social,
economic,
morbidity
and
mortality
burdens.
SARS-CoV-2
infects
cells
following
receptor-mediated
endocytosis
priming
by
cellular
proteases.
Following
uptake,
replicates
autophagosome-like
structures
the
cytosol
its
escape
from
endolysosomes.
Accordingly,
greater
endolysosome
pathway
including
autophagosomes
mTOR
sensor
may
be
targets
for
therapeutic
interventions
against
infection
COVID-19
pathogenesis.
Naturally
existing
compounds
(phytochemicals)
through
their
actions
on
endolysosomes
signaling
pathways
might
provide
relief
COVID-19.
Here,
we
discuss
evidence
some
natural
system
can
inhibit
infectivity
thereby
repurposed
use
Saudi Journal of Biological Sciences,
Journal Year:
2021,
Volume and Issue:
29(2), P. 1197 - 1209
Published: Sept. 17, 2021
This
study
investigated
the
antimicrobial
and
antioxidant
activity
of
three
Spirulina
extracts
(methanol,
acetone,
hexane)
biological
selenium
nanoparticles
(SeNPs)
fabricated
by
Bacillus
subtilis
AL43.
The
results
showed
that
exhibited
against
tested
pathogens.
Besides,
significantly
scavenged
ABTS
DPPH
radicals
in
a
dose-dependent
manner.
methanolic
extract
had
higher
total
phenolic
content,
activity,
than
other
extracts.
were
synthesized
AL43
under
aerobic
conditions
characterized
as
spherical,
crystalline
with
size
65.23
nm
net
negative
charge
-22.7.
We
evidenced
SeNPs
possess
considerable
gram-positive,
gram-negative
bacteria,
strains
from
both
Candida
sp.
Aspergillus
Moreover,
able
to
scavenge
An
association
was
found
between
content
their
activities.
Our
indicate
significant
activities
seem
be
successful
candidates
for
safe
reliable
medical
applications.
Molecules,
Journal Year:
2021,
Volume and Issue:
26(17), P. 5405 - 5405
Published: Sept. 6, 2021
Phenolic
acids
comprise
a
class
of
phytochemical
compounds
that
can
be
extracted
from
various
plant
sources
and
are
well
known
for
their
antioxidant
anti-inflammatory
properties.
A
few
the
most
common
naturally
occurring
phenolic
(i.e.,
caffeic,
carnosic,
ferulic,
gallic,
p-coumaric,
rosmarinic,
vanillic)
have
been
identified
as
ingredients
edible
botanicals
(thyme,
oregano,
rosemary,
sage,
mint,
etc.).
Over
last
decade,
clinical
research
has
focused
on
number
in
vitro
(in
human
cells)
vivo
(animal)
studies
aimed
at
exploring
health
protective
effects
against
severe
diseases.
In
this
review
paper,
authors
first
report
main
structural
features
acids,
important
natural
extraction
techniques.
Subsequently,
target
analysis
is
to
provide
an
overview
recent
investigate
range
pathologic
conditions
(e.g.,
cancer,
cardiovascular
diseases,
hepatotoxicity,
neurotoxicity,
viral
infections-including
coronaviruses-based
ones).
Biology,
Journal Year:
2021,
Volume and Issue:
10(7), P. 589 - 589
Published: June 26, 2021
Currently,
a
worldwide
pandemic
has
been
declared
in
response
to
the
spread
of
coronavirus
disease
2019
(COVID-19),
fatal
and
fast-spreading
viral
infection
caused
by
severe
acute
respiratory
syndrome
2
(SARS-CoV-2).
The
low
availability
efficient
vaccines
treatment
options
resulted
high
mortality
rate,
bringing
world
economy
its
knees.
Thus,
mechanistic
investigations
drugs
capable
counteracting
this
are
demand.
main
protease
(Mpro)
expressed
SARS-CoV-2
targeted
for
development
potential
drug
candidates
due
crucial
role
played
Mpro
replication
transcription.
We
generated
phytochemical
library
containing
1672
phytochemicals
derived
from
56
plants,
which
have
reported
as
having
antiviral,
antibacterial,
antifungal
activity.
A
molecular
docking
program
was
used
screen
top
three
candidate
compounds:
epicatechin-3-O-gallate,
psi-taraxasterol,
catechin
gallate,
had
respective
binding
affinities
−8.4,
−8.5,
−8.8
kcal/mol.
Several
active
sites
protein,
including
Cys145,
His41,
Met49,
Glu66,
Met165,
were
found
interact
with
compounds.
multiple
simulation
profile,
root-mean-square
deviation,
fluctuation,
radius
gyration,
solvent-accessible
surface
area
values
supported
inflexible
nature
docked
protein–compound
complexes.
toxicity
carcinogenicity
profiles
assessed,
showed
that
gallate
favorable
pharmacological
properties
no
adverse
effects.
These
findings
suggest
these
compounds
could
be
developed
part
an
effective
pathway
treat
COVID-19.
Nucleic Acids Research,
Journal Year:
2022,
Volume and Issue:
51(D1), P. D654 - D659
Published: Nov. 18, 2022
Abstract
Natural
products
(NPs)
are
single
chemical
compounds,
substances
or
mixtures
produced
by
a
living
organism
-
found
in
nature.
Evolutionarily,
NPs
have
been
used
as
healing
agents
since
thousands
of
years
and
still
today
continue
to
be
the
most
important
source
new
potential
therapeutic
preparations.
played
key
role
modern
drug
discovery
for
several
diseases.
Furthermore,
following
consumers’
increasing
demand
natural
food
ingredients,
many
efforts
made
discover
low-calorie
sweeteners
recent
years.
SuperNatural
3.0
is
freely
available
database
derivatives.
The
updated
version
contains
449
058
compounds
along
with
their
structural
physicochemical
information.
Additionally,
information
on
pathways,
mechanism
action,
toxicity,
vendor
if
available,
drug-like
space
prediction
diseases
antiviral,
antibacterial,
antimalarial,
anticancer,
target
specific
cells
like
central
nervous
system
(CNS)
also
provided
compounds.
provides
valuable
pool
which
highly
sweet
expected
found.
possible
taste
profile
was
predicted
using
our
published
VirtualTaste
models.
via
http://bioinf-applied.charite.de/supernatural_3,
without
any
login
registration.
Frontiers in Medicine,
Journal Year:
2020,
Volume and Issue:
7
Published: Dec. 11, 2020
Background:
During
the
COVID-19
pandemic
people
are
facing
risks
of
adverse
health
effects
due
to
restrictions
implemented
such
as
quarantine
measures,
reduced
social
contact,
and
self-isolation.
In
this
qualitative
review,
we
collected
data
on
potential
preventive
therapeutic
benefits
Complementary
Integrative
Medicine
(CIM)
that
might
be
useful
during
pandemic.
We
have
reviewed
scientific
literature
summarize
CIM
practices
could
beneficial
for
improving
physical
mental
well-being
population
under
current
circumstances.
It
must
noted
review
is
not
SARS-CoV-2
specific
explicitly
do
intend
make
any
claims
in
article.
Methods
Findings:
A
qualitative,
non-systematic
was
conducted
Medline
identify
describing
approaches
strengthening
health.
For
a
variety
clinical
evidence
identified,
indicating
effects.
include
dietary
measures
selected
micronutrients,
activity,
techniques
from
Mind-Body
Medicine,
single
botanicals
or
botanical
compounds,
spending
time
nature
among
others.
The
conditions
like
obesity
hypertension
special
relevance
here,
these
considered
risk
factors
severe
course
COVID-19.
Moreover,
possibly
direct
effect
immune
functions
parameters
respiratory
tract
infections,
influenza,
were
identified.
findings
helpful
clinicians,
patients,
general
when
discussing
and/or
considering
options.
Conclusions:
offers
options
resilience,
which
also
with
benefit
different
areas
worth
analyzed.
While
has
several
obvious
limitations,
it
serve
starting
point
further
research
topic.
Natural Product Communications,
Journal Year:
2021,
Volume and Issue:
16(10)
Published: Oct. 1, 2021
Hesperidin
and
hesperetin
are
flavonoids
that
abundantly
present
as
constituents
of
citrus
fruits.
These
compounds
have
attracted
attention
several
computational
methods,
mostly
docking
studies,
shown
hesperidin
may
bind
to
multiple
regions
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
(spike
protein,
angiotensin-converting
enzyme
2,
proteases).
has
a
low
binding
energy,
both
with
the
SARS-CoV-2
“spike”
protein
responsible
for
internalization,
also
“PL
pro
”
“M
transforming
early
proteins
virus
into
complex
viral
replication.
This
suggests
these
could
act
prophylactic
agents
by
blocking
mechanisms
infection
replication,
thus
helping
host
cell
resist
attack.
Animals,
Journal Year:
2021,
Volume and Issue:
11(12), P. 3491 - 3491
Published: Dec. 7, 2021
The
chicken
gut
is
the
habitat
to
trillions
of
microorganisms
that
affect
physiological
functions
and
immune
status
through
metabolic
activities
host
interaction.
Gut
microbiota
research
previously
focused
on
inflammation;
however,
it
now
clear
these
microbial
communities
play
an
essential
role
in
maintaining
normal
homeostatic
conditions
by
regulating
system.
In
addition,
helps
reduce
prevent
pathogen
colonization
via
mechanism
competitive
exclusion
synthesis
bactericidal
molecules.
Under
commercial
conditions,
newly
hatched
chicks
have
access
feed
after
36–72
h
hatching
due
hatch
window
routine
hatchery
practices.
This
delay
adversely
affects
potential
inoculation
healthy
impairs
development
maturation
muscle,
system,
gastrointestinal
tract
(GIT).
Modulating
has
been
proposed
as
a
strategy
for
improving
health
productivity
avoiding
undesirable
effects
Using
early-life
programming
ovo
stimulation
with
probiotics
prebiotics,
may
be
possible
avoid
selected
disorders,
poor
immunity,
resistance,
which
broiler
industry
faces
selection
pressures
imposed
increasingly
demanding
market.
