Microalgae as future food: Rich nutrients, safety, production costs and environmental effects

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 927, P. 172167 - 172167

Published: April 4, 2024

Language: Английский

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Chemical Compounds, Bioactivities, and Applications of Chlorella vulgaris in Food, Feed and Medicine

Applied Sciences, Journal Year: 2024, Volume and Issue: 14(23), P. 10810 - 10810

Published: Nov. 22, 2024

This review presents the chemical composition, bioactive properties, and diverse applications of Chlorella vulgaris, a green microalga widely recognized for its exceptional nutritional value therapeutic potential. The study emphasizes presence key nutrients, including high-quality proteins, essential vitamins, minerals, an array compounds such as carotenoids, chlorophyll, polysaccharides. These have been shown to exhibit wide spectrum biological activities, potent antioxidant, anti-inflammatory, immunomodulatory, antiviral, anticancer, antidiabetic, lipid-lowering, detoxifying effects. explores multifaceted C. vulgaris in various sectors, growing role functional food ingredient, nutraceutical supplement animal feed, promising agent combatting chronic diseases. paper also highlights potential enhancing immune responses, mitigating oxidative stress, promoting detoxification heavy metals, improving overall health outcomes. However, current limitations clinical evidence surrounding medicinal efficacy present challenges that need be addressed. Furthermore, significant obstacles remain scaling up production, optimizing cultivation techniques bioavailability. Additionally, this identifies crucial research gaps, particularly techniques, bioavailability, validating vulgaris. By addressing these challenges, holds promise contributing global health, sustainable nutrition, environmental conservation efforts by serving source protein components population while simultaneously having lower impact requiring fewer resources production compared traditional ingredients like soybean meal.

Language: Английский

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Causal relationships between gut microbiota, immune cell, and Non-small cell lung cancer: a two-step, two-sample Mendelian randomization study

Journal of Cancer, Journal Year: 2024, Volume and Issue: 15(7), P. 1890 - 1897

Published: Jan. 1, 2024

Background: Regulating the immune system is a crucial measure of gut microbiota (GM) that influences development diseases.The causal role GM on Non-small cell lung cancer (NSCLC) and whether it can be mediated by cells still unknown.Methods: We performed two-step, two-sample Mendelian randomization study with an Inverse variance weighted (IVW) approach to investigate NSCLC mediation effect between association NSCLC.Results: MR analyses determined protective effects 6 genera (Bacteroides, Roseburia, Alistipes, Methanobrevibacter, Ruminococcus gauvreauii group, Peptococcus).In addition, 38 traits were suggestively associated NSCLC.Of note, illustrated Genus-Peptococcus (Total IVW: OR = 0.790, 95% CI [0.657, 0.950], P 0.012) was large proportion CD45 HLA DR + CD4 in TBNK panel (-034 (95% [-0.070, -0.005]; 0.037), accounting for 14.4% Total effect). Conclusion:The suggested relationship NSCLC, which may cells.

Language: Английский

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Squid meal and shrimp hydrolysate as novel protein sources for dog food

Frontiers in Veterinary Science, Journal Year: 2024, Volume and Issue: 11

Published: Feb. 21, 2024

The world's growing pet population is raising sustainability and environmental concerns for the petfood industry. Protein-rich marine by-products might contribute to mitigating negative effects, decreasing waste, improving economic efficiency. present study evaluated two by-products, squid meal shrimp hydrolysate, as novel protein sources dog feeding. Along with analysis of chemical composition antioxidant activity, palatability was by comparing a commercial diet (basal diet) diets inclusion 150 g kg-1 or hydrolysate using 12 Beagle dogs (2.2 ± 0.03 years). Two in vivo digestibility trials were conducted six dogs, three experimental periods (10 days each) dietary levels (50, 100 kg-1) place basal evaluate effects level on apparent total tract (ATTD), metabolizable energy content, fecal characteristics, metabolites, microbiota. Both presented higher methionine contents than ingredients traditionally used food formulation. Shrimp showed activity meal. First approach taste not affected sources, but animals preference diet. Effects nutrient intake reflected diets, output characteristics increasing both sources. ATTD dry matter, most nutrients when compared diet, suggests their potential be included highly digestible dogs. Although decreased butyrate concentration increased all volatile fatty acids, except butyrate. Fecal microbiota inclusion, whereas significantly abundances Oscillosperaceae (UCG-005), Firmicutes Lactobacillus. Overall, results suggest that constitute promising food, further research needed fully functional value.

Language: Английский

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Effects of Supplementation with Microalgae Extract from Tetradesmus obliquus Strain Mi175.B1.a on Gastrointestinal Symptoms and Mental Health in Healthy Adults: A Pilot Randomized, Double-Blind, Placebo-Controlled, Parallel-Arm Trial

Nutrients, Journal Year: 2025, Volume and Issue: 17(6), P. 960 - 960

Published: March 10, 2025

Microalgae, a marine-derived natural ingredient, has emerged as rich source of bioactive compounds with the potential to modulate gut–brain axis activities. The objective this study was investigate whether supplementation microalgae extract from Tetradesmus obliquus strain Mi175.B1.a (TOME) influences gut health and reduces stress anxiety in healthy adults experiencing mild moderate gastrointestinal (GI) distress. Methods: Fifty-six (age: 31.9 ± 7.7 years; body weight: 71.8 12.6 kg; BMI: 24.6 2.8 kg/m2) were enrolled randomized, double-blind, placebo-controlled, parallel-arm clinical trial. Participants randomly allocated receive capsules containing either 250 mg/day TOME or placebo for four weeks. Primary outcomes included assessment GI symptoms using Gastrointestinal Symptom Rating Scale (GSRS) Bristol Stool (BSS). Secondary focused on subjective evaluation mood, stress, anxiety, well blood pressure responses sympathetic nervous system activation induced by cold pressor test (CPT). In addition, stool, plasma, saliva samples collected assess biomarkers associated activation, intestinal permeability, health. 16S rRNA sequencing performed analyze changes microbial populations. Results: Daily weeks safe tolerated population. significantly reduced GSRS global scores (p = 0.02), constipation 0.05) indigestion 0.03) subcomponent compared Placebo. There also significant increase Shannon’s index before FDR correction 0.05; 0.12) stool butyrate level lower group than Placebo after 4 0.039). Both groups showed reduction perceived scores, but intervention had Negative Affect < 0.001). plasma chromogranin A, biomarker, 0.03). no negative effects lipids other parameters related cardiovascular Conclusions: Overall, these results suggest that 4-week T. improves symptoms, potentially through microbiota, may promote positive mental Additional research should follow up populations increased mechanisms underlying improvements This trial registered at clinicaltrials.gov NCT06425094.

Language: Английский

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Substitution of Poultry Fat with Black Soldier Fly (Hermetia illucens) Larvae Fat in Dog Diets: Effects on Digestibility, Palatability, Peroxidation of Dry Food, Immunity, Blood Biochemistry, and Faecal Characteristics of Adult Dogs

Veterinary Sciences, Journal Year: 2025, Volume and Issue: 12(4), P. 311 - 311

Published: March 29, 2025

This study evaluated the effects of partially or fully replacing poultry fat with black soldier fly larvae (BSFL) on faecal parameters, blood biochemistry, immune responses, nutrient digestibility, food preference, and lipid oxidation in dogs. A total 18 adult Golden Retriever dogs (6 per diet group) were subjected to a digestibility trial for 30 days. Three experimental diets formulated: control (6% fat), BSF3 (3% +3% BSF BSF6 fat). Serum biochemical including urea nitrogen, creatinine, AST, ALT, glucose, cholesterol, triglycerides, protein, immunoglobulin levels (IgE IgG), analysed from samples collected all Faecal consistency scores recorded over 5 days, pH, ammonia nitrogen (ammonia-N), short-chain fatty acids (SCFAs), branched-chain acid (BCFA) concentrations determined during final three days trial. Seven after trial, modified two-bowl preference test was conducted four using 20 assess palatability diets. Lipid by measuring thiobarbituric reactive substances (TBARSs, mg MDA/kg) at baseline (day 0) 2, 4, 7, 10 months storage ambient temperature (23–25 °C). exhibited lowest dry matter organic percentages (p < 0.05). Protein reduced both BSF6, while ether extract significantly lower compared The replacement had no significant effect serum parameters IgE IgG > acetic higher group whereas valeric than groups Although pH not influenced dietary source, SCFA faeces decreased substitution Furthermore, demonstrated rate In conclusion, inclusion dog formulations but adverse health status

Language: Английский

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Protein hydrolysate and oil from fish waste reveal potential as dog food ingredients

Frontiers in Veterinary Science, Journal Year: 2024, Volume and Issue: 11

Published: April 22, 2024

The increased fish consumption by the growing human population in world translates into an increase waste. reintroduction of these by-products food and feed chains presents economic benefits contributes to counteracting their negative environmental impact. Under this context, present study aimed evaluate effects dietary inclusion hydrolysate oil obtained from waste (experimental diet) substitution shrimp salmon (control mainly imported third countries on palatability, apparent total tract digestibility, fecal characteristics metabolites, blood fatty acid profile, flatulence, coat quality adult dogs. A two-bowl test was performed palatability pairwise comparison between two diets. feeding trial conducted according a crossover design with diets experimental diets), six Beagle dogs per diet, periods 6 weeks each. replacement did not affect first diet approach taste, as well intake ratio. Generally, digestibility dry matter, nutrients, energy affected but digestible crude protein (CP) ether extract higher, respectively, control diet. higher eicosapentaenoic docosahexaenoic reflected content long-chain polyunsaturated acids omega-3 index red cells, it quality. significantly CP might have contributed ammonia-N valerate concentrations. Daily output were similar Overall, results suggest that agrifood industry constitute sustainable functional ingredients for dog while adding value wild fisheries, aquaculture, farming under circular economy reducing dependence imports high carbon footprint.

Language: Английский

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Supplementation of tropical red seaweeds improved gut health indices, antioxidant status and immunity in adult dogs

Journal of Applied Phycology, Journal Year: 2024, Volume and Issue: 36(4), P. 2183 - 2198

Published: April 15, 2024

Language: Английский

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Oral supplementation of choline attenuates the development of alcohol-related liver disease (ALD)

Molecular Medicine, Journal Year: 2024, Volume and Issue: 30(1)

Published: Oct. 18, 2024

Abstract Background Chronic alcohol intake is associated with alterations of choline metabolism in various tissues. Here, we assessed if an oral supplementation attenuated the development alcohol-related liver disease (ALD) mice. Methods Female C57BL/6 J mice (n = 8/group) were either pair-fed a liquid control diet, or Lieber DeCarli diet (5% ethanol) ± 2.7 g choline/kg for 29 days. Liver damage, markers intestinal permeability and microbiota composition determined. Moreover, effects on ethanol-induced ex vivo model. Results ALD as determined by histology assessing inflammation (e.g., nitric oxide, interleukin 6 4-hydroxynonenal protein adducts) was choline. Intestinal small intestine being significantly higher ethanol-fed at level controls receiving In contrast, no found composition. Choline also barrier dysfunction tissue vivo, effect almost entirely abolished oxidase inhibitor dimbunol. Conclusion Our results suggest that attenuates related to protection from dysfunction.

Language: Английский

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Macroalgae and microalga blend in dogs' food: Effects on palatability, digestibility, and fecal metabolites and microbiota

Algal Research, Journal Year: 2024, Volume and Issue: 84, P. 103775 - 103775

Published: Oct. 30, 2024

Language: Английский

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