Relationship between the CUBN and the MIA3 gene copy number variation and growth traits in different cattle breeds
Animal Biotechnology,
Journal Year:
2025,
Volume and Issue:
36(1)
Published: Jan. 28, 2025
Copy
number
variations
(CNV)
are
important
genetic
variations.
The
endogenous
factors
cobalamin
receptor
(CUBN)
and
MIA
SH3
domain
ER-derived
factor
3
(MIA3)
associated
with
bone/muscle
development
intramuscular
fat
deposition.
There
have
been
no
reports
on
the
effects
of
CUBN
MIA3
CNVs
growth
traits
Chinese
cattle.
This
study
aimed
to
determine
correlation
between
in
qRT-PCR
was
used
detect
distribution
CNV
expression
levels
their
mRNA,
analysis
conducted
traits.
differentially
expressed
different
breeds
cattle,
correlated
significantly
body
height,
hip
slanting
length,
width
Grassland
Red
cattle
(CYH);
eye
muscle
area
Yanbian
(YB)
Yan
Yellow
(YH).
showed
CYH
YB
only
one
deletion
type
occurred
YH
mRNA
patterns
tissues.
In
conclusion,
is
a
novel
molecular
marker
that
could
be
exploited
breeding.
Language: Английский
Copy Number Variations of the NSMF Gene and Their Associations with Growth Traits in Three Chinese Sheep Breeds
Genes,
Journal Year:
2025,
Volume and Issue:
16(2), P. 218 - 218
Published: Feb. 13, 2025
Copy
number
variations
(CNVs)
are
a
significant
source
of
genetic
variation
and
have
been
shown
to
influence
growth
traits
in
livestock.
This
study
aimed
validate
previous
CNV
candidates
within
the
NSMF
gene
(XM_015093798.1)
identify
novel
markers
for
molecular
breeding
sheep.
Using
quantitative
PCR
(qPCR),
we
genotyped
CNVs
(chr3:
586,001-601,000)
assessed
their
associations
with
three
Chinese
sheep
breeds:
Chaka
(CKS,
n
=
312),
Hu
(HS,
67),
Small-tailed
Han
(STHS,
70).
Our
results
revealed
differences
genotype
frequencies
across
breeds,
highest
proportion
deletions
observed
STHS
(98.44%)
CKS
(90.57%),
while
HS
exhibited
higher
frequency
duplications
(14.06%).
No
were
between
(p-value
>
0.05).
However,
could
markedly
affected
cannon
circumference
0.021),
individuals
carrying
normal
showing
larger
circumference.
Additionally,
marginally
association
was
found
body
diagonal
length
0.050).
Future
investigations
employing
cohorts
warranted
definitively
establish
utility
as
programs.
Language: Английский
Detection of Copy Number Variations in Woori-Heukdon Populations with the Illumina PorcineSNP60 Bead-Chip Array
Yong‐Min Kim,
No information about this author
Ha-Seung Seong,
No information about this author
Seok-Joo Ha
No information about this author
et al.
Animals,
Journal Year:
2025,
Volume and Issue:
15(6), P. 774 - 774
Published: March 9, 2025
This
study
investigated
copy
number
variations
(CNVs)
in
2112
pigs
from
five
populations:
Korean
Duroc
(DUC),
Native
Pig
(KNP),
and
their
crossbred
offspring
(F1,
F2,
WRH).
CNVs
were
detected
using
PennCNV
QuantiSNP,
with
CNVRuler
identifying
698
CNV
regions
(CNVRs),
covering
109
Mb
(4.83%)
of
the
porcine
genome.
Comparison
previous
studies
on
swine
revealed
CNVR
overlap
rates
ranging
31.12%
(French
Yorkshire)
to
81.27%
(Xiang),
9.06%
newly
identified
CNVRs.
DUC
showed
most
CNVRs
(n
=
384),
followed
by
WRH
225).
Meanwhile,
F1
F2
exhibited
far
fewer
(five
seven,
respectively).
Functional
enrichment
analysis
highlighted
various
genes
overlapping
CNVRs,
including
1236
572
WRH,
linked
biological
processes.
The
quantitative
trait
loci
(QTLs),
particular
traits
such
as
average
daily
gain
(4.24%
QTLs
DUC,
4.51%
In
contrast,
KNP,
F1,
populations
a
higher
frequency
containing
overlapped
drip
loss.
These
findings
indicate
that
may
inherit
growth
DUC.
provides
better
understanding
pigs,
which
can
potentially
be
used
improving
genetic
merits
pig
populations.
Language: Английский
Multi-tool copy number detection highlights common body size-associated variants in miniature pig breeds from different geographical regions
Jan Berghöfer,
No information about this author
Nadia Khaveh,
No information about this author
Stefan Mundlos
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et al.
BMC Genomics,
Journal Year:
2025,
Volume and Issue:
26(1)
Published: March 22, 2025
Copy
number
variations
(CNVs)
represent
a
common
and
highly
specific
type
of
variation
in
the
genome,
potentially
influencing
genetic
diversity
mammalian
phenotypic
development.
Structural
variants,
such
as
deletions,
duplications,
insertions,
have
frequently
been
highlighted
key
factors
traits
high-production
pigs.
However,
comprehensive
CNV
analyses
miniature
pig
breeds
are
limited
despite
their
value
biomedical
research.
This
study
performed
whole-genome
sequencing
36
pigs
from
nine
America,
Asia
Oceania,
Europe.
By
employing
multi-tool
approach
(CNVpytor,
Delly,
GATK
gCNV,
Smoove),
accuracy
identification
was
improved.
In
total,
34
homozygous
CNVs
overlapped
with
exonic
regions
all
samples,
suggesting
role
expressing
phenotypes
uniform
growth
patterns,
fertility,
or
metabolic
function.
addition,
386
copy
(CNVRs)
shared
by
were
detected,
covering
33.6
Mb
(1.48%
autosomal
genome).
Further,
132
exclusive
CNVRs
identified
for
American
breeds,
47
Asian
Oceanian
114
European
breeds.
Functional
enrichment
analysis
revealed
genes
within
involved
body
height
determination
other
growth-related
parameters.
Exclusive
located
region
enriched
lipid
metabolism
minipigs,
reproductive
cardiovascular
features
selected
groups,
quantitative
trait
loci
associated
size,
meat
quality,
reproduction,
disease
susceptibility
highlighted.
investigation
landscape
minipigs
underlines
impact
selective
breeding
on
structural
variants
its
development
breed
across
geographical
areas.
The
provides
valuable
resource
future
studies
effects
artificial
selection
livestock
genomes.
Language: Английский
Genome wide copy number diversity in Indian goat breeds scaled to world-wide breeds
Small Ruminant Research,
Journal Year:
2025,
Volume and Issue:
unknown, P. 107525 - 107525
Published: May 1, 2025
Language: Английский
Application of Omics in Donkey Meat Research: A Review
Qiying Zhu,
No information about this author
Yongdong Peng,
No information about this author
Xiaotong Liu
No information about this author
et al.
Animals,
Journal Year:
2025,
Volume and Issue:
15(7), P. 991 - 991
Published: March 29, 2025
This
review
comprehensively
examines
the
molecular
basis
of
donkey
meat
characteristics
and
growth-associated
genes,
integrating
findings
from
multiple
omics
approaches.
study
nutritional
profile
meat,
which
is
rich
in
protein,
essential
amino
acids,
unsaturated
fatty
acids.
Through
a
systematic
literature
search
across
Web
Science,
Google
Scholar,
PubMed,
Scopus
databases
(2000-2024),
we
collected
analyzed
data
400
research
articles
using
predefined
inclusion
criteria
focused
on
composition,
approaches,
quality
parameters
populations.
The
also
evaluates
various
factors
affecting
quality,
including
breed
differences,
age,
feeding
management,
storage
conditions.
Advanced
genomic
transcriptomic
analyses
have
revealed
numerous
candidate
such
as
ACTN3,
BMP7,
NR6A1,
Wnt7a,
HOXC8,
LCORL,
TPM2,
TPM3,
associated
with
growth
traits
characteristics,
providing
valuable
insights
for
genetic
improvement
programs.
Furthermore,
discusses
authentication
methods
ensuring
preventing
adulteration,
highlighting
integration
traditional
modern
analytical
Language: Английский
Comparative Study on the Sperm Proteomes of Horses and Donkeys
Hong Ren,
No information about this author
Xin Wen,
No information about this author
Qianqian He
No information about this author
et al.
Animals,
Journal Year:
2024,
Volume and Issue:
14(15), P. 2237 - 2237
Published: July 31, 2024
The
reproductive
performance
of
horse
sperm
and
donkey
has
been
reported
to
differ.
Sperm
proteins
play
a
crucial
role
in
viability
fertility.
Although
differences
between
species
are
known,
no
prior
study
investigated
disparities
the
proteome
horses
donkeys.
Therefore,
this
characterized
compared
proteomes
donkeys
using
4D-DIA
mass
spectrometry
technology.
We
identified
3436
3404
sperm.
Of
these,
3363
were
expressed
both
sperm,
with
73
being
specifically
41
According
data
analysis,
exhibited
greater
percentage
motility
progressive
movement
straight-line
than
horses,
as
well
lower
percentages
static
slow
horses.
Joint
analysis
results
from
their
CEROS
II-read
parameters
demonstrated
possible
association
patterns.
These
findings
suggest
that
there
discrepancies
expression
levels
protein
compositions
certain
specific
may
be
responsible
for
these
two
species.
Language: Английский
Deciphering new insights into copy number variations as drivers of genomic diversity and adaptation in farm animal species
C. S. Celus,
No information about this author
Sheikh Firdous Ahmad,
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Munish Gangwar
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et al.
Gene,
Journal Year:
2024,
Volume and Issue:
939, P. 149159 - 149159
Published: Dec. 11, 2024
Language: Английский
Structural variations in livestock genomes and their associations with phenotypic traits: a review
Frontiers in Veterinary Science,
Journal Year:
2024,
Volume and Issue:
11
Published: Nov. 12, 2024
Genomic
structural
variation
(SV)
refers
to
differences
in
gene
sequences
between
individuals
on
a
genomic
scale.
It
is
widely
distributed
the
genome,
primarily
form
of
insertions,
deletions,
duplications,
inversions,
and
translocations.
Due
its
characterization
by
long
segments
large
coverage,
SVs
significantly
impact
genetic
characteristics
production
performance
livestock,
playing
crucial
role
studying
breed
diversity,
biological
evolution,
disease
correlation.
Research
contributes
an
enhanced
understanding
chromosome
function
important
for
hereditary
diseases
mechanisms.
In
this
article,
we
review
concept,
classification,
main
formation
mechanisms,
detection
methods,
advancement
research
genomes
cattle,
buffalo,
equine,
sheep,
goats,
aiming
reveal
basis
phenotypic
traits
adaptive
mechanisms
through
research,
which
will
provide
theoretical
better
utilizing
resources
herbivorous
livestock.
Language: Английский