The Pathogenomics of the Respiratory Mycoplasma bovis Strains Circulating in Cattle Around the Texas Panhandle, USA
Ethan Dudley,
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Matthew A. Scott,
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Hatem Kittana
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et al.
Pathogens,
Journal Year:
2025,
Volume and Issue:
14(2), P. 167 - 167
Published: Feb. 8, 2025
Bovine
respiratory
disease
(BRD)
is
a
major
economic
and
animal
welfare
issue
in
the
beef
industry.
Mycoplasma
bovis
one
of
main
causal
organisms,
particularly
chronic
cases.
Due
to
difficulty
isolating
M.
from
clinical
isolates,
there
lack
information
on
genetic
diversity
this
pathogen
Texas
panhandle
region
United
States.
Therefore,
our
objective
was
provide
genome-level
characterization
isolated
lung
lesions
dairy
cattle
panhandle.
Fifty-four
isolates
displaying
mycoplasma-like
growth
were
recovered
bovine
by
Veterinary
Medical
Diagnostic
Laboratory
2021
2022.
Of
these
32
determined
be
via
species-specific
qPCR
using
uvrC
gene.
Long-read
whole-genome
sequencing
used
identify
key
virulence
factors,
antimicrobial
resistance
genes,
assess
isolates.
Fisher’s
exact
tests
associations
between
isolate
characteristics
host
metadata,
including
state
origin,
type
operation,
age,
sex.
Our
results
indicate
that
considerable
among
despite
their
shared
geography
panhandle,
though
significant
clustering
based
metadata
observed.
Analysis
pangenome
showed
study
also
harbor
diverse
array
but
no
genes
identified
study.
Language: Английский
Alteration in Tracheal Morphology and Transcriptomic Features in Calves After Infection with Mycoplasma bovis
Fan Liu,
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Fei Yang,
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Lei Guo
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et al.
Microorganisms,
Journal Year:
2025,
Volume and Issue:
13(2), P. 442 - 442
Published: Feb. 18, 2025
Mycoplasma
bovis
is
one
of
the
most
important
pathogens
in
animal
husbandry,
and
current
infection
morbidity
rates
are
increasing
year
by
year,
causing
great
losses
to
farming
industry
seriously
affecting
welfare.
In
this
study,
we
took
tracheal
tissues
from
calves
infected
with
M.
make
pathological
tissue
sections
for
observation,
selected
transcriptome
sequencing
screen
differentially
expressed
genes
based
on
threshold
|log2FoldChange|
>
1
Padjust
<
0.05
functional
enrichment,
explore
depth
potential
mechanisms
bovine
damage
caused
tracheitis.
Experiments
were
conducted
observe
changes
after
through
trachea
bovis-infected
calves.
From
results,
mined
main
differential
metabolic
pathways
It
was
found
that
cricoid
cartilage
congested
hemorrhagic
calves,
showed
localized
necrosis
epithelial
cells,
disorganization,
high
inflammatory
cell
infiltration
interepithelial
lamina
propria,
some
detachment.
Transcriptome
identified
4199
DEGs,
including
1378
up-regulated
2821
down-regulated
genes.
KEGG
enrichment
analysis
indicated
enriched
59
significantly
differing
signaling
pathways,
a
number
related
tracheitis
induced
unearthed.
The
major
ones
included
IL-17,
Toll-like
receptor,
JAK/STAT,
PI3K-Akt
pathway,
etc.
trachea,
results
also
significant
differences
expression
key
such
as
IL-6
factor,
CASP8,
APOA1.
Language: Английский
Major Causative Bacteria of Dairy Cow Mastitis in the Inner Mongolia Autonomous Region, China, 2015–2024: An Epidemiologic Survey and Analysis
Veterinary Sciences,
Journal Year:
2025,
Volume and Issue:
12(3), P. 197 - 197
Published: Feb. 21, 2025
In
this
study,
we
sought
to
evaluate
the
prevalence
of
bacterial
pathogens
mastitis
in
dairy
cattle
Inner
Mongolia
Autonomous
Region,
China.
The
study
was
conducted
from
2015
2024
using
a
total
12,053
clinical
(CM)
and
sub-clinical
(SCM)
samples.
were
isolated
identified
by
standard
bacteriological
mycological
methods.
most
common
Escherichia
coli
(13.82%),
Staphylococcus
aureus
(10.28%),
Klebsiella
spp.
(8.96%),
Streptococcus
agalactiae
(7.45%),
uberis
(6.60%),
coagulase-negative
staphylococci
(5.84%),
dysgalactiae
(4.21%).
From
2017,
primary
responsible
for
causing
cows
agalactiae.
2018,
frequently
pathogen
aureus.
Notably,
isolation
rate
increased
12.31%
21.72%,
7.52%
14.01%
2019–2024.
Mycoplasma
only
detected
cases,
with
separation
as
high
6.95%.
summary,
environmental
is
gradually
increasing,
while
that
contagious
has
been
continuously
declining.
This
indicates
current
prevention
strategies
infectious
are
effective.
As
next
step,
it
will
be
important
develop
new
specifically
targeting
pathogenic
microorganisms.
Language: Английский
Mycoplasma bovis : A review of vaccination and diagnostic initiatives
Isaac Dayo Olorunshola,
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Kabiru Ahmad,
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A.R. Peters
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et al.
CABI Reviews,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 26, 2025
Abstract
Mycoplasma
bovis
infections
in
cattle
constitute
a
worldwide
problem
with
significant
detrimental
economic
impacts
on
industry.
Mastitis,
pneumonia,
arthritis,
keratoconjunctivitis,
otitis
media
and
genital
disorders
are
its
clinical
manifestations.
Presently,
no
vaccines
commercially
available;
antimicrobial
resistance
is
increasing;
diagnostic
sensitivity
testing
needs
to
be
improved;
new
rapid
diagnosis
kits
eminent
for
implementation
of
treatment
antimicrobials.
We
conducted
systematic
search
databases
such
as
PubMed,
Scopus,
Web
Science,
Google
Scholar,
AGRIS
African
Journals
Online
(AJOL),
from
1995
2024.
Searched
keywords,
as,
bovis,
M
:
vaccine
development,
techniques
strain
variability
using
the
predefined
criteria
were
used
address
review
objectives.
Although
they
have
preventative
function,
–
killed,
live
attenuated,
subunit
types
face
difficulties
because
M.
strains
vary
widely.
Every
approach
has
own
set
benefits
drawbacks,
those
that
been
studies
include
conventional
culture
identification,
serological
testing,
immunohistochemical
demonstration
tissues,
sophisticated
molecular
like
PCR,
qPCR,
next-generation
sequencing.
For
early
detection,
successful
treatment,
vaccination
efficacy
monitoring,
accurate
crucial.
Future
directions
managing
-associated
diseases
improving
accessibility
creating
broad-spectrum
vaccinations.
By
incorporating
these
developments,
it
may
possible
enhance
health
cattle,
promote
sustainability
livestock
production,
increase
food
security.
This
points
urgent
need
further
research
innovation
advancement
support
Language: Английский
Validation of a rapid on-farm culture system for group classification of clinical mastitis-causing pathogens
JDS Communications,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 1, 2025
Language: Английский
Integrating the Transcriptome and Proteome to Postulate That TpiA and Pyk Are Key Enzymes Regulating the Growth of Mycoplasma Bovis
Microorganisms,
Journal Year:
2024,
Volume and Issue:
12(10), P. 2012 - 2012
Published: Oct. 3, 2024
is
a
global
problem
for
the
cattle
industry
due
to
its
high
infection
rates
and
associated
morbidity,
although
pathophysiology
poorly
understood.
In
this
study,
Language: Английский
Ultra-High-Performance Liquid Chromatography–Orbitrap-MS-Based Untargeted Lipidomics Reveal Lipid Characteristics of a Clinical Strain of Mycoplasma bovis from Holstein Cow
Veterinary Sciences,
Journal Year:
2024,
Volume and Issue:
11(11), P. 577 - 577
Published: Nov. 18, 2024
is
a
global
concern
for
the
cattle
industry
owing
to
its
high
rates
of
infection
and
resulting
morbidity,
but
there
are
no
reports
on
lipid
composition
metabolic
pathways.
This
study
examined
lipidomics
Language: Английский
Macrophage extracellular traps are induced by Mycoplasma bovis in bovine macrophages through NADPH oxidase/ROS‐dependent manner and their antibacterial efficacy
Ahmed Adel Baz,
No information about this author
Shengli Chen,
No information about this author
Huafang Hao
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et al.
The FASEB Journal,
Journal Year:
2024,
Volume and Issue:
38(23)
Published: Dec. 9, 2024
Mycoplasma
bovis
has
emerged
as
a
significant
pathogen
in
cattle,
leading
to
considerable
economic
losses
the
cattle
industry.
It
is
associated
with
various
clinical
syndromes,
including
pneumoniae,
mastitis,
and
arthritis.
The
innate
immune
response,
particularly
macrophages,
plays
crucial
role
combating
infections
caused
by
such
pathogens.
release
of
macrophage
extracellular
traps
(METs)
represents
novel
defense
mechanism
employed
macrophages;
however,
impact
M.
on
formation
METs
bovine
macrophages
remains
unknown.
Therefore,
primary
objective
this
study
investigate
which
affects
evaluate
their
bactericidal
efficacy.
Our
findings
revealed
that
cell
lines
released
DNA
fibrils
colocalized
histones
cellular
proteins
response
infection,
visualized
confocal
scanning
electron
microscopy.
Moreover,
was
found
depend
NADPH
oxidase,
for
reactive
oxygen
species
generation.
Importantly,
led
lysis
indicated
lactate
dehydrogenase,
process
be
independent
apoptosis
pyroptosis.
infection
effective
both
killing
restricting
its
growth.
Overall,
our
first
described
how
were
produced
responded
demonstrated
function
bacterial
killing,
helpful
improve
understanding
host's
against
pathogen.
Language: Английский