The Role of Calprotectin in the Diagnosis and Treatment of Inflammatory Bowel Disease

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 1996 - 1996

Published: Feb. 25, 2025

The management of inflammatory bowel disease (IBD), which is characterized by immunodeficiency, has attracted increasing attention, highlighting the necessity for more precise and streamlined diagnostic approaches in clinics. Calprotectin, an immune cell-derived protein with inherent anti-inflammatory antimicrobial properties, plays a pivotal role regulation intestinal homeostasis. Its expression levels are intricately linked to IBD activity, enabling differentiation between non-inflammatory states while predicting recurrence risks. As non-invasive biomarker, fecal calprotectin (FC) serum (SC) analysis offers high reproducibility clinical utility, facilitating both diagnosis real-time monitoring. Beyond its specificity distinguishing from other gastrointestinal disorders, also emerges as promising therapeutic target, due dual modulating pathways interacting gut microbiota. With collaborative advancements standardized detection protocols innovative research methodologies, it anticipated that calprotectin-based strategies will be integrated into mainstream practice IBD.

Language: Английский

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Fecal and Serum Calprotectin Concentrations in Cats With Chronic Enteropathies Before and During Treatment

Journal of Veterinary Internal Medicine, Journal Year: 2025, Volume and Issue: 39(2)

Published: March 1, 2025

ABSTRACT Background Chronic enteropathies (CE) are common in cats. Reliable biomarkers that can distinguish different causes and predict or monitor responses to treatment currently lacking. Hypothesis/Objectives Evaluate calprotectin concentrations serum feces as potential cats with CE. Animals Forty‐three either chronic inflammatory enteropathy (CIE; n = 25) small cell gastrointestinal lymphoma (SCGL; 18) 36 healthy were prospectively enrolled. Methods Fecal determined before during treatment. Cats CIE treated diet, prednisolone, diet SCGL prednisolone plus chlorambucil without diet. Results Compared controls, fecal concentration was significantly higher CE (median, ≤ 161 ng/g; range, 161–2827 vs. median, 161–790; p 0.01). No significant differences found (median 161–1920 189 161–2827; 0.3) 1291 mg/L; 1291–15 358 1291–6422; 0.99) between SCGL. decreased after 161–1897 161–656; 0.02). Conclusions might be a good biomarker for diagnosis monitoring subset of Serum do not seem useful Neither nor could differentiate from

Language: Английский

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Single Enema Fecal Microbiota Transplantation in Cats With Chronic Enteropathy

Journal of Veterinary Internal Medicine, Journal Year: 2025, Volume and Issue: 39(3)

Published: April 10, 2025

ABSTRACT Background Chronic enteropathies (CE) are common in cats, and alterations of the intestinal microbiota might be involved pathogenesis. Hypothesis/Objectives To evaluate efficacy a single enema fecal transplantation (FMT) improving dysbiosis clinical scores cats with CE. Animals Twenty‐eight either chronic inflammatory enteropathy (CIE; n = 19) or small cell gastrointestinal lymphoma (SCGL; 9) were prospectively enrolled. Methods Eleven randomly selected to receive FMT (FMT‐group), 17 used as controls. Clinical activity was determined using Feline Enteropathy Activity Index (FCEAI), feline index (DI) on day (T0) 30 days after (T1). Results At T0, 14/28 had an abnormal DI > 0. No significant difference found from T0 T1 group (mean[SD]: 0.01[2.5] vs. 0.7[2.1]; p 0.47). between control at −0.7[2.1] 0.8[1.8]; 0.92). FCEAI significantly decreased compared (median[IQR] 10.0[7.7–11.3] 4.5[4–5]; 0.002). 4.5[4–5] 4[3–5.75]; 0.64). Conclusions In this study, did not lead improvement CE

Language: Английский

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Alterations in the Intestinal Microbiome and Metabolic Profile of British Shorthair Kittens Fed with Milk Replacer

Animals, Journal Year: 2024, Volume and Issue: 14(16), P. 2346 - 2346

Published: Aug. 14, 2024

With the rising popularity of pet cats as companion animals, survival newborn kittens is often threatened by factors such inadequate nursing, maternal behavior and blood incompatibility. These challenges require use milk replacers for nurturing. To investigate effects that feeding with an experimental replacer (EMR) have on growth development, intestinal microbiota, immune response nutrient metabolism, 12 British shorthair were randomly divided into two groups after nursing first week life. Kittens fed queen's or EMR, whereby served control (CON) group. The findings revealed CON group exhibited superoxide dismutase (SOD) activity total antioxidant capacity (T-AOC) (

Language: Английский

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Serum Transcobalamin Concentration in Cats—Method Validation and Evaluation in Chronic Enteropathies and Other Conditions

Veterinary Sciences, Journal Year: 2024, Volume and Issue: 11(11), P. 552 - 552

Published: Nov. 9, 2024

Hypocobalaminemia is common in cats with chronic enteropathy (FCE). However, the disruptions cobalamin metabolism are not fully understood and may vary across species. Cobalamin distributed to target tissues via binding transcobalamin (TC) blood, which has been evaluated cats. Thus, an in-house sandwich-ELISA was established evaluate serum total TC concentrations FCE. Surplus sera served analytically validate assay, were compared among FCE other diseases (gastrointestinal neoplasia, cholangiohepatopathy, neoplastic or non-neoplastic conditions) healthy controls. Observed-to-expected ratios for serial dilutions ranged from 72.4 145.6% 75.1-126.7% spiking-and-recovery. Intra- inter-assay variability <17.7% <17.2% preliminary reference interval feline <160-2795 aU/L (lower detection limit: 160 aU/L). Serum levels significantly decreased (

Language: Английский

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