Probiotic administration aggravates dextran sulfate sodium salt-induced inflammation and intestinal epithelium disruption in weaned pig

Animal Microbiome, Journal Year: 2025, Volume and Issue: 7(1)

Published: Jan. 16, 2025

A. muciniphila (AKK) has attracted extensive research interest as a potential next-generation probiotics, but its role in intestinal pathology is remains unclear. Herein, this study was conducted to investigate the effects of DSM 22,959 on growth performance, barrier function, microecology and inflammatory response weaned piglets stimulated by dextran sulfate sodium salt (DSS). Twenty-four Duroc × Landrace Yorkshire (DLY) used for 2 factorial arrangement treatments were divided into four groups with six each group. From 1 15 d, CA DA orally fed 1.0 1011 colony-forming units per day, while CON DCON received gastric infusion anaerobic sterile saline day. The pigs challenged (DCON, DA) or not (CON, CA) DSS from day 9 end experiment slaughtered 16. Presence DSS-challenged resulted numerically increased diarrhea rate, blood neutrophilic granulocyte, serum C-reactive protein immunoglobulin M levels, reduced final weight, average daily feed intake gain. decrease villus height, villous height: crypt depth ratio digestibility accompanied lower expression ZO1, ZO2, Claudin1, DMT1, CAT1, SGLT1 PBD114 genes, well decreased enzyme activities alkaline phosphatase, lactase, sucrase maltase group compared abundance Bifdobacterium, Lactobacillus, muciniphila, Ruminococcus gnavus higher digesta than those responses dramatically changed simultaneous presence DSS: level IL17A, IL17F, IL23, RORγt, Stat3 elevated other pig groups. Our result showed that oral aggravates DSS-induced health damage piglet, which may attribute deteriorating morphology, dysbiosis microbiota disorders.

Language: Английский

Dihydromyricetin switches pyroptosis to apoptosis during Aeromonas hydrophila infection in Mylopharyngodon piceus

Fish & Shellfish Immunology, Journal Year: 2025, Volume and Issue: unknown, P. 110460 - 110460

Published: May 1, 2025

Language: Английский