Oral and parenteral vaccination of broiler chickens with Recombinant NetB antigen from Clostridium perfringens confers significant protection against necrotic enteritis DOI Creative Commons
Mohammad Ali Shamshirgaran, Mehdi Golchin

BMC Veterinary Research, Journal Year: 2025, Volume and Issue: 21(1)

Published: March 14, 2025

Necrotic enteritis is a devastating economic disease caused by Clostridium perfringens in poultry. NetB toxin from C. type G the major responsible cause of necrotic enteritis. After ban on growth-promoting antibiotics, alternative effective intervention approaches such as vaccination birds were considered critical to control To date, no commercial vaccines with proven efficacy have been approved against In this study, we evaluated oral and parenteral based antigen choose best prime-boosting strategy The broiler chickens orally vaccinated either previously developed recombinant probiotic bacterium, Lactobacillus casei strain expressing toxoid, followed booster purified toxoid (oral/parenteral), or alone (parenteral-only). Immunizations these elicited strong specific anti-NetB antibody responses provided significant protection infectious challenge. Additionally, represented mean body weight gains compared groups during experiment. current study showed that using could provide chickens.

Language: Английский

Oral and parenteral vaccination of broiler chickens with Recombinant NetB antigen from Clostridium perfringens confers significant protection against necrotic enteritis DOI Creative Commons
Mohammad Ali Shamshirgaran, Mehdi Golchin

BMC Veterinary Research, Journal Year: 2025, Volume and Issue: 21(1)

Published: March 14, 2025

Necrotic enteritis is a devastating economic disease caused by Clostridium perfringens in poultry. NetB toxin from C. type G the major responsible cause of necrotic enteritis. After ban on growth-promoting antibiotics, alternative effective intervention approaches such as vaccination birds were considered critical to control To date, no commercial vaccines with proven efficacy have been approved against In this study, we evaluated oral and parenteral based antigen choose best prime-boosting strategy The broiler chickens orally vaccinated either previously developed recombinant probiotic bacterium, Lactobacillus casei strain expressing toxoid, followed booster purified toxoid (oral/parenteral), or alone (parenteral-only). Immunizations these elicited strong specific anti-NetB antibody responses provided significant protection infectious challenge. Additionally, represented mean body weight gains compared groups during experiment. current study showed that using could provide chickens.

Language: Английский

Citations

0