Seaweed-derived mixed extracts exhibit immunomodulatory properties on porcine alveolar macrophages
Sara Frazzini,
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Lauretta Turin,
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G. Vanosi
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et al.
The Veterinary Journal,
Journal Year:
2025,
Volume and Issue:
unknown, P. 106358 - 106358
Published: April 1, 2025
Antimicrobial
resistance
is
a
growing
global
concern,
prompting
for
antibiotic
alternatives
in
animal
production.
Seaweed,
abundant
bioactive
compounds
with
anti-inflammatory
properties,
offers
natural
substitute
to
synthetic
compounds.
Considering
this,
the
objective
of
present
study
was
evaluate
bioactivity
three
seaweeds
1:1
combination
Ascophyllum
nodosum,
Palmaria
palmata,
and
Ulva
lactuca.
Initially,
polyphenol,
flavonoid,
total
phlorotannin
content
seaweed
species
were
assessed
through
colorimetric
assays.
Subsequently,
first
evaluated
an
inhibition
protein
precipitation
assay
then
confirmed
vitro
gene
expression
assays
LPS-stimulated
porcine
alveolar
macrophages
(PAMs).
The
evaluation
molecules
revealed
high
TPC
(1487.67±40.39
1763.57±69.01mg
TAE/100mg
sample,
respectively),
as
well
TFC
(95.68±3.62
126.09±7.34mg
CE/100mg
sample)
TPhC
(0.167±0.02
0.23±0.01mg
PGE/100mg)
AN
UL,
respectively.
inhibiting
disclosed
that
extracts
combining
two
algae
(ANUL,
ANPP,
PPUL)
more
effective
than
effect
exhibited
by
each
single
extract.
assessment
significant
down-regulation
IL-1β
TNF-α
extracts.
In
contrast,
TGF-β
showed
increasing
trend.
These
findings,
along
confirmation
molecules,
highlight
algae's
potential,
making
them
suitable
antibiotics
disease
prevention
livestock
sector.
Therefore,
future
research
should
explore
specific
validate
their
efficacy
vivo
confirm
potential
use
Language: Английский
Exploiting Chestnut Biochar as a Functional and Circular Ingredient in Weaned Piglet Diets
Agriculture,
Journal Year:
2025,
Volume and Issue:
15(10), P. 1082 - 1082
Published: May 17, 2025
Background:
Achieving
sustainable
development
in
accordance
with
Agenda
2030
(Sustainable
Development
Goals
12,
13,
and
17)
has
challenged
the
livestock
sector
especially
swine
farming.
Strategies
focused
on
reducing
environmental
impact
improving
feed
efficiency
have
therefore
been
explored.
Due
to
its
beneficial
properties,
application
of
biochar
represents
an
interesting
solution.
This
study
evaluates
effects
supplementation
growth
performance
health
parameters
weaned
piglets.
Methods:
A
total
223
piglets
were
divided
into
two
experimental
groups:
control
(CTRL)
group
treatment
(TRT
group).
The
experiment
involved
dietary
treatments:
CTRL
was
fed
a
standard
diet,
while
TRT
same
diet
supplemented
1%
chestnut
biochar.
Weekly
measurements
included
body
weight,
intake,
fecal
scores.
Fecal
samples
collected
for
microbiological
analysis
evaluation
digestibility.
Results:
No
significant
differences
observed
between
groups
terms
principal
zootechnical
parameters.
showed
lower
E.
coli
counts
feces
at
14
days
decrease
diarrhea
frequency
28
(32.14%
vs.
3.23%
TRT;
p
=
0.009).
Protein
digestibility
higher
(79.5
±
1.74%)
compared
(75.0
2.05%;
0.004).
Additionally,
had
significantly
levels
derivates
reactive
oxygen
metabolites
than
(293.44
59.28
553.98
61.59
Carratelli
units
≤
0.001).
Conclusions:
inclusion
diets
post-weaning
can
improve
status
animals.
Biochar
could
thus
be
used
as
valuable
functional
ingredient
within
innovative
nutritional
strategy
aimed
management
gastrointestinal
problems
during
weaning
period.
Language: Английский