Large-Scale Computational Modeling of H5 Influenza Variants Against HA1-Neutralizing Antibodies DOI Creative Commons
Colby T. Ford, Shirish Yasa,

Khaled Obeid

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: July 17, 2024

Abstract The United States Department of Agriculture has recently released reports that show samples from 2022-2024 highly pathogenic avian influenza (H5N1) have been detected in mammals and birds (1). To date, the Centers for Disease Control there 27 humans infected with H5N1 2024 (2). broader potential impact on human health remains unclear. In this study, we computationally model 1,804 protein complexes consisting various H5 isolates 1959 to against 11 hemagglutinin domain 1 (HA1)-neutralizing antibodies. This study shows a trend weakening binding affinity existing antibodies over time, indicating virus is evolving immune escape our medical defenses. We also found based wide variety host species geographic locations which was observed transmitted mammals, not single central reservoir or location associated H5N1’s spread. These results indicate move epidemic pandemic status near future. illustrates value high-performance computing rapidly protein-protein interactions viral genomic sequence data at-scale functional insights into preparedness. Research Context Evidence before Previous studies shown cases transmissions are increasing frequency, concern health. Since 1997, nearly thousand reported 52% fatality rate. analyses indicated specific mutations allow “host jumping” between (3). There evidence recent strains reduced neutralization sera (4). Added provides comprehensive look at mutational space presents computational predictions HA1-neutralizing derived vaccinated patients humanized mice representative HA1 proteins. confirm other enable zoonosis affect affinities tested. Furthermore, through phylogenetic analyses, quantify avian-to-mammalian persistent circulation North America Europe. Taken together, continuous transmission increase immuno-evasive HA sampled time suggest antigenic drift source spillover risk. Implications all available Our findings worsening antibody binding, along risks public Through previous can now monitor interest, quantified by their evasion, inform monitoring circulating beyond. addition, these may help guide future vaccine therapeutic development fight infections humans.

Language: Английский

Large-scale computational modelling of H5 influenza variants against HA1-neutralising antibodies DOI
Colby T. Ford, Shirish Yasa,

Khaled Obeid

et al.

EBioMedicine, Journal Year: 2025, Volume and Issue: 114, P. 105632 - 105632

Published: March 17, 2025

Language: Английский

Citations

0
Large-Scale Computational Modeling of H5 Influenza Variants Against HA1-Neutralizing Antibodies DOI Creative Commons
Colby T. Ford, Shirish Yasa,

Khaled Obeid

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: July 17, 2024

Abstract The United States Department of Agriculture has recently released reports that show samples from 2022-2024 highly pathogenic avian influenza (H5N1) have been detected in mammals and birds (1). To date, the Centers for Disease Control there 27 humans infected with H5N1 2024 (2). broader potential impact on human health remains unclear. In this study, we computationally model 1,804 protein complexes consisting various H5 isolates 1959 to against 11 hemagglutinin domain 1 (HA1)-neutralizing antibodies. This study shows a trend weakening binding affinity existing antibodies over time, indicating virus is evolving immune escape our medical defenses. We also found based wide variety host species geographic locations which was observed transmitted mammals, not single central reservoir or location associated H5N1’s spread. These results indicate move epidemic pandemic status near future. illustrates value high-performance computing rapidly protein-protein interactions viral genomic sequence data at-scale functional insights into preparedness. Research Context Evidence before Previous studies shown cases transmissions are increasing frequency, concern health. Since 1997, nearly thousand reported 52% fatality rate. analyses indicated specific mutations allow “host jumping” between (3). There evidence recent strains reduced neutralization sera (4). Added provides comprehensive look at mutational space presents computational predictions HA1-neutralizing derived vaccinated patients humanized mice representative HA1 proteins. confirm other enable zoonosis affect affinities tested. Furthermore, through phylogenetic analyses, quantify avian-to-mammalian persistent circulation North America Europe. Taken together, continuous transmission increase immuno-evasive HA sampled time suggest antigenic drift source spillover risk. Implications all available Our findings worsening antibody binding, along risks public Through previous can now monitor interest, quantified by their evasion, inform monitoring circulating beyond. addition, these may help guide future vaccine therapeutic development fight infections humans.

Language: Английский

Citations

0