Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15
Published: Nov. 29, 2024
Intranasal administration is a convenient route for drug delivery that can be applied procedural sedation. However, there currently limited exploration into fixed dosing regimens. This study was to investigate the pharmacokinetics (PK), pharmacodynamics (PD), bioavailability (BA) and safety of dexmedetomidine after doses intranasal intravenous in healthy male female subjects.
Language: Английский
Journal of Surgery, Journal Year: 2024, Volume and Issue: 12(2), P. 11 - 19
Published: March 19, 2024
Background The quality of postoperative sleep is vital for surgical patients. A large number patients after surgery suffer from disorders. There are plenty studies on aim this study to do a bibliometric analysis the top-100 cited articles during last 10 years, providing some clues investigators. Methods Publication retrieval was conducted in Web Science (WoS) Core Collection 12 January 2024. 100 most frequently were identified and analyzed by VOSviewer Excel. We mainly publication year, citations, usage count, author, institution, country/region, journal keywords. Results citations ranged 20 124 WoS Collection, with median 35 mean 40.79. USA (n = 39), China 22) Canada (n=9) ranked top three terms publications citations. Univ Copenhagen, Toronto, Lundbeck Ctr Fast Track Hip & Knee Arthroplasty institutions leading researches sleep. journals specialized Anesthesiology recorded high-quality articles. Postoperative pain, sleep, quality, life delirium highly used keywords, while general anesthesia, fatigue, cognitive impairment dysfunction latest topics. Conclusion At present, have focused impacts disorders pharmacological therapies However, non-pharmacological management should be paid more attention future.
Language: Английский
Citations
0
Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15
Published: Nov. 29, 2024
Intranasal administration is a convenient route for drug delivery that can be applied procedural sedation. However, there currently limited exploration into fixed dosing regimens. This study was to investigate the pharmacokinetics (PK), pharmacodynamics (PD), bioavailability (BA) and safety of dexmedetomidine after doses intranasal intravenous in healthy male female subjects.
Language: Английский
Citations
0