Sodium-Glucose-Cotransporter-2 Inhibitor Therapy and Intermitted Fasting in Cardiorenal Syndrome: The Role of Glucose-Mediated Oxidative Stress

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(3), P. 746 - 746

Published: Jan. 24, 2025

Cardiorenal syndrome (CRS) is a complex clinical disorder characterized by the interplay between heart and kidney dysfunction. This condition exacerbated comorbidities such as diabetes mellitus, which contribute to glucose-mediated oxidative stress, further complicating management of CRS. The CRS has evolved with discovery sodium-glucose-cotransporter-2 (SGLT2) inhibitors, have been established effective agents in reducing hyperglycemia demonstrated cardiorenal protective effects. Concurrently, intermittent fasting gained attention an intervention without pharmacological treatment for its metabolic benefits, including improved glucose metabolism insulin regulation sensitivity, both potential reduction stress. review provides summary current findings on roles SGLT2 inhibitors managing CRS, particular focus We evaluate mechanisms these interventions exert their effects, identify gaps research, offer recommendations future studies. While demonstrate more research needed elucidate long-term efficacy, safety, synergistic

Language: Английский

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Dietary Restrictions and Cancer Prevention: State of the Art

Nutrients, Journal Year: 2025, Volume and Issue: 17(3), P. 503 - 503

Published: Jan. 29, 2025

Worldwide, almost 10 million cancer deaths occurred in 2022, a number that is expected to rise 16.3 by 2040. Primary prevention has long been acknowledged as crucial approach reducing incidence. In fact, between 30 and 50 percent of all tumors are known be preventable eating healthy diet, staying active, avoiding alcohol, smoking, being overweight. Accordingly, many international organizations have created tumor guidelines, which underlie the importance following diet emphasizes plant-based foods while minimizing consumption red/processed meat, sugars, processed foods, alcohol. However, further research needed define relationship effect specific diets or nutritional components on prevention. Interestingly, reductions food intake dietetic restrictions can extend lifespan yeast, nematodes, flies, rodents. Despite controversial results humans, those approaches potential ameliorate health via direct indirect effects signaling pathways involved onset. Here, we describe latest knowledge cancer-preventive dietary biochemical processes involved. Molecular, preclinical, clinical studies evaluating different fasting strategies will also reviewed.

Language: Английский

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Energy Metabolism and Brain Aging: Strategies to Delay Neuronal Degeneration

Cellular and Molecular Neurobiology, Journal Year: 2025, Volume and Issue: 45(1)

Published: April 21, 2025

Abstract Aging is characterized by a gradual decline in physiological functions, with brain aging being major risk factor for numerous neurodegenerative diseases. Given the brain’s high energy demands, maintaining an adequate ATP supply crucial its proper function. However, advancing age, mitochondria dysfunction and deteriorating metabolism lead to reduced overall production impaired mitochondrial quality control (MQC). As result, promoting healthy has become key focus contemporary research. This review examines relationship between aging, highlighting connection MQC metabolism, proposes strategies delay targeting metabolism.

Language: Английский

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Acrolein-Triggered Ferroptosis and Protection by Intermittent Fasting via the AMPK/NRF2-CLOCK/BMAL1 Pathway

Toxics, Journal Year: 2025, Volume and Issue: 13(5), P. 369 - 369

Published: May 1, 2025

Environmental pollution significantly exacerbates various diseases, particularly those affecting the cardiovascular and respiratory systems. Our previous studies have shown that acrolein, an environmental pollutant, promotes atherosclerosis by downregulating circadian clock genes (CLOCK/BMAL1) disrupting rhythm. We also found intermittent fasting (IF), closely linked to clock, may mitigate induced acrolein. Ferroptosis, a newly identified form of regulated cell death, is associated with acceleration atherosclerotic development, but its relationship not well understood. In this study, we explored potential IF alleviate ferroptosis modulating clock. in vivo experiments revealed reversed upregulated CLOCK/BMAL1 APOE-/- mice. human umbilical vein endothelial cells (HUVECs), discovered acrolein-induced leads while short-term starvation (STS, model) effect. Acrolein suppressed expression AMP-activated protein kinase (AMPK), nuclear factor erythroid 2-related 2 (NRF2), CLOCK/BMAL1, which were restored subsequent STS treatments. Additionally, overexpression mitigated ferroptosis, consistent findings from CLOCK gene knockout experiments. Notably, AMPK/NRF2 be mutually regulated. Concurrently, AMPK NRF2 signaling pathways interdependent act concert. conclusion, our suggest modulates CLOCK/BMAL1-AMPK/NRF2 pathway offering strategy address health issues related pollution.

Language: Английский

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Dietary Restriction and Lipid Metabolism: Unveiling Pathways to Extended Healthspan

Nutrients, Journal Year: 2024, Volume and Issue: 16(24), P. 4424 - 4424

Published: Dec. 23, 2024

Dietary restriction (DR) has been reported to be a significant intervention that influences lipid metabolism and potentially modulates the aging process in wide range of organisms. Lipid plays pivotal role regulation longevity. In this review, we summarize studies on relation DR. As potent slow down aging, DR demonstrated promising effects metabolism, influencing processes across various species. The current review focuses relationships among DR-related molecular signaling proteins such as sirtuins, pathways target rapamycin insulin/insulin-like growth factor (IGF)-1, aging. Furthermore, presents research results diet-associated changes cell membrane lipids alterations caused by commensal bacteria, highlighting importance Overall, explores interplay between diet, while presenting untapped areas for further understanding process.

Language: Английский

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