How do we increase deceased donor kidney utilization and reduce discard? DOI
Venkatesh K. Ariyamuthu,

Abd Assalam Qannus,

Bekir Tanrıöver

et al.

Current Opinion in Organ Transplantation, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 13, 2025

Purpose of review This aims to address the critical issue expanding deceased donor kidney pool and reducing discard rates viable kidneys in United States. It highlights advances organ preservation techniques explores strategies for by leveraging suboptimal high-risk nonuse kidneys, including those affected acute injury (AKI), hepatitis C virus (HCV), B (HBV). Recent findings Innovations preservation, hypothermic normothermic machine perfusion, have demonstrated efficacy improving outcomes marginal extended-criteria kidneys. The integration regional perfusion (NRP) donation after cardiac death (DCD) donors has enhanced utilization graft viability. Additionally, research confirms that from AKI HCV-positive donors, when managed with appropriate protocols, yield comparable long-term standard transplants. Emerging data on HBV-positive further underscore their potential safely expand transplant access targeted antiviral prophylaxis. Summary Optimizing requires a multi-faceted approach, advancements technologies, evidence-based decision-making organs, policy innovations. Leveraging these can help growing shortage, enhance outcomes, ensure broader life-saving

Language: Английский

How do we increase deceased donor kidney utilization and reduce discard? DOI
Venkatesh K. Ariyamuthu,

Abd Assalam Qannus,

Bekir Tanrıöver

et al.

Current Opinion in Organ Transplantation, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 13, 2025

Purpose of review This aims to address the critical issue expanding deceased donor kidney pool and reducing discard rates viable kidneys in United States. It highlights advances organ preservation techniques explores strategies for by leveraging suboptimal high-risk nonuse kidneys, including those affected acute injury (AKI), hepatitis C virus (HCV), B (HBV). Recent findings Innovations preservation, hypothermic normothermic machine perfusion, have demonstrated efficacy improving outcomes marginal extended-criteria kidneys. The integration regional perfusion (NRP) donation after cardiac death (DCD) donors has enhanced utilization graft viability. Additionally, research confirms that from AKI HCV-positive donors, when managed with appropriate protocols, yield comparable long-term standard transplants. Emerging data on HBV-positive further underscore their potential safely expand transplant access targeted antiviral prophylaxis. Summary Optimizing requires a multi-faceted approach, advancements technologies, evidence-based decision-making organs, policy innovations. Leveraging these can help growing shortage, enhance outcomes, ensure broader life-saving

Language: Английский

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