Biological Activity of Monoterpene-Based Scaffolds: A Natural Toolbox for Drug Discovery

Molecules, Journal Year: 2025, Volume and Issue: 30(7), P. 1480 - 1480

Published: March 27, 2025

One of the most common strategies used in drug design is molecular scaffold approach, which combines traditional medicine based on natural active compounds derived from plants with modern synthetic development. Designing new skeletons enables extensive modifications both bioavailability and biological activity. An excellent example a monoterpenes group, serves as core structure for building more complex molecules by attaching various chemical groups. Their ability to interact targets, combined structural versatility, makes them promising scaffolds pharmaceutical research green chemistry applications. This review paper focuses selected (carvacrol, carvone, citral, menthol, menthone, β-pinene, thymol, verbenone), are frequently scaffolds. The newly designed derivatives exhibit activities, including anticancer, antibacterial, antiviral, neuroprotective, many others.

Language: Английский

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Antifungal and Toxicological Evaluation of Natural Compounds Such as Chitosan, Citral, and Hexanal Against Colletotrichum asianum

Horticulturae, Journal Year: 2025, Volume and Issue: 11(5), P. 474 - 474

Published: April 28, 2025

The Colletotrichum genus is one of the ten most relevant pathogenic fungi in post-harvest sector owing to its high infection rate tropical fruits; however, search for alternatives synthetic fungicides crucial because their adverse effects on health and environment. This study evaluated efficacy chitosan (CH), citral (CT), hexanal (HX) against asianum, as well toxicological potential these treatments. In vitro tests, 1.0% CH, 0.03% CT, 0.06% HX significantly inhibited fungal development parameters radial growth, sporulation, biomass, germination by 78–100% (p < 0.05). Furthermore, toxicity index was low moderate concentrations using cucumber tomato seed a model. Toxicokinetic predictions suggest that molecules do not pose danger human consumption, suggesting they are promising chemical control phytopathogenic fungi.

Language: Английский

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Validation of shikimate dehydrogenase as the herbicidal target of drupacine and screening of target-based compounds with high herbicidal activity

Pesticide Biochemistry and Physiology, Journal Year: 2024, Volume and Issue: 204, P. 106077 - 106077

Published: Aug. 5, 2024

Language: Английский

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Pelargonic acid’s interaction with the auxin transporter PIN1: A potential mechanism behind its phytotoxic effects on plant metabolism

Plant Science, Journal Year: 2024, Volume and Issue: 349, P. 112278 - 112278

Published: Oct. 10, 2024

Language: Английский

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Potential of essential oils as natural herbicides: a comprehensive review of current developments

Plant Growth Regulation, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 19, 2024

Language: Английский

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