The value of lipocalin-2 as an inflammatory marker in children with COVID-19
CHILD`S HEALTH,
Journal Year:
2025,
Volume and Issue:
20(1), P. 55 - 63
Published: March 5, 2025
Background.
The
purpose
was
to
study
the
relationship
between
lipocalin-2
indicators
and
markers
of
inflammation
severity
in
children
with
COVID-19.
Materials
methods.
We
conducted
a
cohort,
observational,
retrospective
involving
88
patients
aged
1
month
18
years
COVID-19
that
laboratory-confirmed
by
polymerase
chain
reaction.
were
hospitalized
Kyiv
City
Children’s
Clinical
Infectious
Disease
Hospital
(Kyiv,
Ukraine).
All
participants
divided
into
two
groups
depending
on
respiratory
manifestations:
46
lesions
upper
tract,
who
had
manifestations
rhinitis,
or
sinusitis,
pharyngitis,
tonsillitis
(control
group)
42
lower
tract
clinical
picture
laryngotracheitis,
bronchitis
pneumonia
(main
group).
During
comprehensive
examination
first
day
their
stay
hospital,
blood
serum
collected
for
further
level
enzyme
immunoassay.
Human
Neutrophil
Gelatinase-associated
Lipocalin,
NGAL
kit
(BT
LAB,
China)
working
measurement
range
5–600
ng/ml
sensitivity
2.01
used.
Statistical,
analytical
methods
method
empirical
research
applied
work.
To
calculate
obtained
results,
we
used
statistical
software
EZR
v.
1.54.
Results.
In
control
group,
lipocalin
70.3
±
27.7
ng/ml,
while
main
indicator
higher,
124.60
27.08
(p
=
0.03).
According
results
study,
correlation
found
increased
leukocytes
(r
0.889,
p
0.001),
erythrocyte
sedimentation
rate
0.53,
D-dimer
0.393,
C-reactive
protein
0.54,
0.001)
X-ray
changes
lungs
0.56,
0.001).
Conclusions.
There
levels
children.
Language: Английский
A Review on Risk Factors, Traditional Diagnostic Techniques, and Biomarkers for Pneumonia Prognostication and Management in Diabetic Patients
Diseases,
Journal Year:
2024,
Volume and Issue:
12(12), P. 310 - 310
Published: Dec. 2, 2024
People
of
all
ages
can
contract
pneumonia,
and
it
cause
mild
to
severe
disease
even
death.
In
addition
being
a
major
death
for
elderly
people
those
with
prior
medical
conditions
such
as
diabetes,
isthe
world’s
biggest
infectious
children.
Diabetes
mellitus
is
metabolic
condition
high
glucose
level
leading
lower
limb
amputation,
heart
attacks,
strokes,
blindness,
renal
failure.
Hyperglycemia
known
impair
neutrophil
activity,
damage
antioxidant
status,
weaken
the
humoral
immune
system.
Therefore,
diabetic
patients
are
more
susceptible
pneumonia
than
without
diabetes
linked
fatalities.
The
absence
quick,
precise,
simple,
affordable
ways
identify
etiologic
agents
community-acquired
has
made
diagnostic
studies’
usefulness
contentious.
Improvements
in
biological
markers
molecular
testing
techniques
have
significantly
increased
ability
diagnose
other
related
respiratory
infections.
Identifying
risk
factors
developing
early
might
lead
significant
decrease
mortality
pneumonia.
this
regard,
various
factors,
traditional
techniques,
pathomechanisms
discussed
review.
Further,
biomarkers
next-generation
sequencing
briefly
summarized.
Finding
distinguish
between
bacterial
viral
could
be
crucial
because
identifying
precise
pathogen
would
stop
unnecessary
use
antibiotics
effectively
save
patient’s
life.
Language: Английский