Eye-specific detection and a multi-eye integration model of biological motion perception DOI Creative Commons
Massimo De Agrò, Daniela C. Rößler, Paul S. Shamble

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Sept. 24, 2023

Abstract The term biological motion refers to the peculiar kinematics of living organisms. Their interconnected joints move at a fixed distance from each other, pattern that is common among all locomotive, rigid animals. Across animal kingdom, many species have developed specialized circuitry visually recognize biologically moving stimuli and discriminate them other patterns. Recently, this skill has also been observed in distributed visual system jumping spiders. These eight-eyed animals use three their eye pairs perceive motion. Then, gaze remaining pair shifted towards detected object for further inspection. When presented with stimulus random one, spiders turn face latter, demonstrating discrimination. In current paper, we systematically tested ability displays using every single eye-pair, by blocking others paint. were able only when anterior-lateral eyes unblocked, performing chance level pairs. Crucially, preferred stimulus, not one. To explain preference reversal hypothesized model, describing how eyes’ specialization detecting feeds into multi-eye integration system, generating more complex behavior combination simple, single-eye responses. We propose in-built modularity may be solution limited resources these invertebrates’ brains, constituting novel approach processing.

Language: Английский

Cognivue Clarity® characterizes amyloid status and preclinical Alzheimer's disease in biomarker confirmed cohorts in the Bio-Hermes Study DOI Creative Commons
James E. Galvin, Michael J. Kleiman,

Paul W. Estes

et al.

Journal of Alzheimer s Disease, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 26, 2025

Cognivue Clarity® is an FDA-cleared computerized cognitive test to screen for impairment included in the Bio-Hermes Study blood-based and digital biomarkers' ability mild (MCI) Alzheimer's disease (AD). A subset of cognitively normal individuals have amyloid deposition (Preclinical AD) but no current assessment can identify these absence expensive biomarkers. We examined differences Clarity performance between positive negative whether could differentiate True Controls (cognitively normal/amyloid negative), Preclinical AD positive), MCI due (MCI-AD, impaired/amyloid positive). was administered all participants who also had PET Performance compared biomarker-defined groups: (n = 297), 95), MCI-AD 113). global scores distinguished from (p < 0.001) differentiated versus 0.014) 0.001). Three subtests [Shape Discrimination 0.004), Visual Salience 0.008), Adaptive Motor Control 0.004)] 3-test mean AD. The composite correlated with Amyloid (r -0.433) pTau217 -0.400). identified both White Black participants. Clarity, a 10-min battery, screens impairment, characterizes individuals, identifies This has great potential as cost- time-effective strategy enroll prevention trials.

Language: Английский

Citations

1
Eye-specific detection and a multi-eye integration model of biological motion perception DOI Creative Commons
Massimo De Agrò, Daniela C. Rößler, Paul S. Shamble

et al.

Journal of Experimental Biology, Journal Year: 2024, Volume and Issue: 227(12)

Published: May 16, 2024

'Biological motion' refers to the distinctive kinematics observed in many living organisms, where visually perceivable points on animal move at fixed distances from each other. Across kingdom, species have developed specialized visual circuitry recognize such biological motion and discriminate it other patterns. Recently, this ability has been distributed system of jumping spiders. These eight-eyed animals use six eyes perceive motion, while remaining two (the principal anterior medial eyes) are shifted across scene further inspect detected objects. When presented with a biologically moving stimulus random one, spiders turn face latter, clearly demonstrating between them. However, remains unclear whether necessary for behavior, all secondary can perform discrimination, or single eye-pair is task. Here, we systematically tested stimuli by testing alone. Spiders were able only when lateral unblocked, performed chance levels configurations. Interestingly, showed preference over - unlike past work. We therefore propose new model describing how specialization detecting contributes multi-eye integration system. This generates more complex behavior through combination simple, single-eye responses. posit that in-built modularity may be solution limited resources these invertebrates' brains, constituting novel approach processing.

Language: Английский

Citations

3
Habituation to visual stimuli is independent of boldness in a jumping spider DOI
Narmin Beydizada, Francesco Cannone, Stano Pekár

et al.

Animal Behaviour, Journal Year: 2024, Volume and Issue: 213, P. 61 - 70

Published: May 17, 2024

Language: Английский

Citations

3
Study Replication: Shape Discrimination in a Conditioning Procedure on the Jumping Spider Phidippus regius DOI Creative Commons
Eleonora Mannino, Lucia Regolin, Enzo Moretto

et al.

Animals, Journal Year: 2023, Volume and Issue: 13(14), P. 2326 - 2326

Published: July 17, 2023

Spiders possess a unique visual system, split into eight different eyes and divided two fully independent pathways. This peculiar organization begs the question of how information is processed, whether classically recognized Gestalt rules perception hold true. In previous experiment, we tested ability jumping spiders to associate geometrical shape with reward (sucrose solution), then generalize learned association partially occluded version shape. The was presented together broken same former should be perceived as whole only in case animals, like humans, are able amodally complete an object partly hidden by occluder; otherwise, shapes would identical. There, but failed generalize. Here, present replication increased number subjects, DeepLabCut-based scoring procedure, improved statistical analysis. results experiment follow closely direction effects observed work fail rise significance. We discuss importance study replication, especially highlight use automated procedures maximize objectivity behavioral studies.

Language: Английский

Citations

5
Eye-specific detection and a multi-eye integration model of biological motion perception DOI Creative Commons
Massimo De Agrò, Daniela C. Rößler, Paul S. Shamble

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Sept. 24, 2023

Abstract The term biological motion refers to the peculiar kinematics of living organisms. Their interconnected joints move at a fixed distance from each other, pattern that is common among all locomotive, rigid animals. Across animal kingdom, many species have developed specialized circuitry visually recognize biologically moving stimuli and discriminate them other patterns. Recently, this skill has also been observed in distributed visual system jumping spiders. These eight-eyed animals use three their eye pairs perceive motion. Then, gaze remaining pair shifted towards detected object for further inspection. When presented with stimulus random one, spiders turn face latter, demonstrating discrimination. In current paper, we systematically tested ability displays using every single eye-pair, by blocking others paint. were able only when anterior-lateral eyes unblocked, performing chance level pairs. Crucially, preferred stimulus, not one. To explain preference reversal hypothesized model, describing how eyes’ specialization detecting feeds into multi-eye integration system, generating more complex behavior combination simple, single-eye responses. We propose in-built modularity may be solution limited resources these invertebrates’ brains, constituting novel approach processing.

Language: Английский

Citations

0