Overcoming drug resistance through extracellular vesicle-based drug delivery system in cancer treatment DOI Open Access
Long Tai Zheng,

R. S. F. Chang,

B. Liang

et al.

Cancer Drug Resistance, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 12, 2024

Drug resistance is a major challenge in cancer therapy that often leads to treatment failure and disease relapse. Despite advancements chemotherapeutic agents targeted therapies, cancers develop drug resistance, making these treatments ineffective. Extracellular vesicles (EVs) have gained attention for their potential applications delivery because of natural origin, biocompatibility, ability cross biological barriers. Using the unique properties EVs could enhance accumulation at target sites, minimize systemic toxicity, precisely specific cells. Here, we discuss characteristics functionalization EVs, mechanisms engineered overcome resistance. This review provides comprehensive overview EV-based systems overcoming We highlight revolutionize offer promising strategies more effective modalities.

Language: Английский

Overcoming drug resistance through extracellular vesicle-based drug delivery system in cancer treatment DOI Open Access
Long Tai Zheng,

R. S. F. Chang,

B. Liang

et al.

Cancer Drug Resistance, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 12, 2024

Drug resistance is a major challenge in cancer therapy that often leads to treatment failure and disease relapse. Despite advancements chemotherapeutic agents targeted therapies, cancers develop drug resistance, making these treatments ineffective. Extracellular vesicles (EVs) have gained attention for their potential applications delivery because of natural origin, biocompatibility, ability cross biological barriers. Using the unique properties EVs could enhance accumulation at target sites, minimize systemic toxicity, precisely specific cells. Here, we discuss characteristics functionalization EVs, mechanisms engineered overcome resistance. This review provides comprehensive overview EV-based systems overcoming We highlight revolutionize offer promising strategies more effective modalities.

Language: Английский

Citations

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