Coated sodium butyrate and vitamin D₃ supplementation improve gut health through influencing intestinal immunity, barrier, and microflora in early‐stage broilers

Journal of the Science of Food and Agriculture, Journal Year: 2024, Volume and Issue: 104(7), P. 4058 - 4069

Published: Jan. 25, 2024

Abstract BACKGROUND Intestinal development and function are critical to maintaining sustained broiler growth. The present study aimed evaluate the effects of coated sodium butyrate (CSB) vitamin D 3 (VD ) on intestinal immunity, barrier, oxidative stress microflora in early‐stage broilers. In total, 192 one‐day‐old broilers were assigned a 2 × factorial design including two dietary supplements at different levels, which main VD (3000 or 5000 IU kg −1 CSB (0 1 g ). RESULTS results showed that supplementation increased ileal goblet cells (GCs) numbers, villus height decreased crypt depth proliferating cell nuclear antigen expression high‐level cluster differentiation expression. reduced serum d ‐lactate, endotoxin (ET), adrenocorticotropic hormone, corticosterone malondialdehyde (MDA) concentrations total antioxidant capacity (T‐AOC) level. Meanwhile, ET concentration. Furthermore, T‐AOC, lysozyme (LYZ) transforming growth factor (TGF)‐β MDA, whereas MDA secretory immunoglobulin A. up‐regulated claudin1, superoxide dismutase 1, TGF‐β LYZ mRNA down‐regulated interleukin‐1β combined with Faecalibaculum abundance. Spearman correlation analysis was related immune barrier function. CONCLUSION Dietary improved early gut health by promoting development, enhancing capacity, strengthening favorable composition bacterial flora. © 2024 Society Chemical Industry.

Language: Английский

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The New Buffer Salt-Protected Sodium Butyrate Promotes Growth Performance by Improving Intestinal Histomorphology, Barrier Function, Antioxidative Capacity, and Microbiota Community of Broilers

Biology, Journal Year: 2024, Volume and Issue: 13(5), P. 317 - 317

Published: May 1, 2024

In this study, a commercial sodium butyrate protected by new buffer salt solution (NSB) was tested to determine whether it can be used as an antibiotic alternative in broiler production. A total of 192 1-day-old broilers were randomly allocated three dietary treatments: soybean meal diet (CON), (ANT, basal + 100 mg/kg aureomycin), and NSB (basal 800 NSB). The growth performance, serum anti-inflammatory cytokines, intestinal morphology, gut barrier function, antioxidative parameters, SCFAs’ content, cecal microbiota analyzed. result showed that significantly improved ADFI ADG (p < 0.01), decreased FCR 0.01). Serum cytokine IL-10 up-regulated pro-inflammatory TNF-α down-regulated 0.05) supplementation. H&E results VH the VH/CD ratio increased jejunum ileum group. Furthermore, ZO-1 claudin-1 occludin 0.01) mucin-2 Additionally, SOD T-AOC/MDA MDA level also ANT group jejunum. Propionic acid butyric content segments. 16S rRNA sequencing no significant difference > alpha beta diversity among groups. LEFSe analysis indicated Peptostreptococcaceae, Colidextribacter, Firmicutes, Oscillospira, Erysipelatoclostridiaceae, which promote SCFA production 0.05), identified dominant taxon-enriched bacterial genera Spearman correlation revealed Colidextribacter with ADFI, ADG, VH, unclassified_f__Peptostreptococcaceae IL-10, positively correlated 0.05). claudin-1, SOD, T-AOC, similarly, positive correlation. conclusion, enhanced performance improving regulating function antioxidant capacity, cecum microbiota, showing its potential use antibiotics poultry nutrition.

Language: Английский

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Sodium Butyrate Alleviates the Toxic Effect of Aflatoxin B1 on Largemouth Bass (Micropterus Salmoides)

Published: Jan. 1, 2025

Language: Английский

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Challenges in Poultry Production Systems and Nutritional Interventions

Animals, Journal Year: 2025, Volume and Issue: 15(4), P. 530 - 530

Published: Feb. 13, 2025

Chicken is the most produced and consumed meat in world [...].

Language: Английский

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Growth Performance and Gut Health of Cold-Stressed Broilers in Response to Supplementation with a Combination of Sodium Butyrate and Vitamin D3

Animals, Journal Year: 2025, Volume and Issue: 15(6), P. 861 - 861

Published: March 17, 2025

The current experiment aimed to investigate the effects of sodium butyrate (SB) and vitamin D3 (VD3) supplementation on growth performance, immune status, antioxidant capacity, gut health young broilers under cold stress. A total 144 1-day-old Arbor Acres chicks were randomly allotted three treatments with 6 replicates 8 birds: (1) basal diet; (2) diet + stress; (3) 1 g/kg SB 2000 IU/kg VD3 Birds exposed stress at 16 ± °C for 72 h (d 18–21) 26 control. results indicated that SB/VD3 could alleviate reduction in average daily gain (ADG) caused by (p < 0.05). decreased serum endotoxin level ileal interleukin-1β gene expression upregulated interleukin-10 nuclear factor erythroid 2-related 2 (Nrf2) compared cold-stressed birds Furthermore, altered composition microbiota, including a decrease Clostridium_sensu_stricto_1, whereas prevented reduction. In conclusion, mitigated negative performance intestines strengthening intestinal barrier function stabilizing microbiota balance broiler chicks, these can help manage

Language: Английский

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Exploring the Dietary Strategies of Coated Sodium Butyrate: Improving Antioxidant Capacity, Meat Quality, Fatty Acid Composition, and Gut Health in Broilers

Genes, Journal Year: 2025, Volume and Issue: 16(4), P. 433 - 433

Published: April 5, 2025

Background/Objectives: Broiler chickens are excellent animals for protein production and play an essential role in the food industry. The purpose of this study is to investigate effect coated sodium butyrate (CSB) on biochemical indices, antioxidant capacity, meat quality, fatty acid composition, gut health Xianju broilers. Methods: A total 192 one-day-old broilers were randomly divided into four treatment groups: basal diet (CK), with 250 mg/kg CSB (CSB250), 500 CSB500 (CSB500), 1000 (CSB1000). Each group included six replicates, eight chicks per replicate. Results: We found that supplementation diets has no function plasma indices; however, CSB1000 exhibited markedly elevated TG levels. Furthermore, at different concentrations significantly increased antioxidase capacity Moreover, breast supplemented displayed a higher shear force, pH24h, inosinic content than CK meat. Breast fed showed improved evidenced by levels polyunsaturated acids (C16:1, C18:2, C22:4, C22:6). optimized microbiota particularly enhancing abundance Firmicutes Firmicutes/Bacteroidetes ratio. Conclusions: Collectively, these findings offer basis extensive application as feed addition enhance quality broiler sector.

Language: Английский

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Alternative to antimicrobial growth promoters in the diets of broilers challenged with subclinical necrotic enteritis

Poultry Science, Journal Year: 2024, Volume and Issue: 103(9), P. 103986 - 103986

Published: June 17, 2024

Necrotic enteritis (NE) is a disease of worldwide distribution, which affects young broilers and causes economic losses on scale 6 billion dollars per year. For decades, NE was controlled in poultry flocks by dietary administration low doses antimicrobial growth promoters (AGPs). However, an increase incidence noted after the AGP ban. This study aimed to compare effect antibiotic (Enramycin) diet combination sodium butyrate, hydrolyzed yeast, zinc proteinate (ViligenTM) broiler diets regarding performance, blood parameters, intestinal permeability, morphology lesions, carcass yield challenged with Eimeria spp. Clostridium perfringens simulate subclinical necrotic enteritis. A total 1,150 one-day-old male chickens initial average weight 43.9 ± 0.65 g were allocated 50 experimental pens. Animals divided into five groups: Negative control (NC) without additives; Positive (PC) 0.12 ton-1 Enramycin (8%); V500, V1000, V1500 addition 500, 1.000, 1.500 ViligenTM, respectively. All animals at 7 days age C. 17, 18, 19 for induction NE. The fed all concentrations ViligenTM showed similar compared PC broilers. NC higher FCR from 1 33 (1.42 vs. 1.39) (P = 0.048) 42 (1.51 1.49) < 0.001). had fewer lesions 28 when treatment 0.05) that inclusion resulted lower damage. At 21 days, V500 group characteristics (VH:VD 4.9 vs 3.5) (P<0.001). Thus, this study, model damage performance obtained Enramycin.

Language: Английский

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The New Buffer Salt Protected Sodium Butyrate Promotes Growth Performance by Improving Intestinal Histomorphology, Barrier Function, Antioxidative Capacity, and Microbiota Community of Broilers

Published: April 2, 2024

In this study, a commercial sodium butyrate protected by new buffer salt solution (NSB) was tested to determine whether it can be used as an antibiotic alternative in broiler production. 192 1-day-old broilers were randomly allocated three dietary treatments: soybean meal diet (CON), (ANT, basal + 100 mg/kg aureomycin), and NSB (basal 800 NSB). The growth performance, serum anti-inflammatory cytokines, intestinal morphology, gut barrier function, antioxidative parameters, SCFAs content, cecal microbiota analyzed. result showed that significantly improved ADFI, ADG (p &lt; 0.01), decreased FCR 0.01). Serum cytokine IL-10 up-regulated pro-inflammatory TNF-α down-regulated 0.05) supplementation. H&amp;E results VH VH: CD ratio increased the jejunum ileum group. Furthermore, ZO-1 claudin-1 occludin 0.01) mucin-2 group, respectively. Additionally, SOD T-AOC/MDA MDA level also ANT group jejunum. Propionic acid butyric content segments. 16S rRNA sequencing no significant difference &gt; alpha beta diversity among groups. LEFSe analysis indicated Peptostreptococcaceae, Colidextribacter, Firmicutes, Oscillospira, Erysipelatoclostridiaceae, which promote SCFA production 0.05), identified dominant taxon-enriched bacterial genera Spearman correlation revealed Colidextribacter with ADG, VH, unclassified_f__Peptostreptococcaceae IL-10, positively correlated 0.05). ADFI claudin-1, SOD, T-AOC, similarly, positive correlation. conclusion, enhanced performance improving regulating function antioxidant capacity, cecum microbiota, showing its potential use antibiotics poultry nutrition.

Language: Английский

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Bacillus licheniformis suppresses Clostridium perfringens infection via modulating inflammatory response, antioxidant status, inflammasome activation and microbial homeostasis in broilers

Poultry Science, Journal Year: 2024, Volume and Issue: 103(11), P. 104222 - 104222

Published: Aug. 22, 2024

Pathogenic bacteria infection, especially Clostridium perfringens (C. perfringens), markedly threatened the health of animals, and further caused huge economic loss. In this study, Bacillus licheniformis HJ0135 (BL) was used. Oxford cup bacteriostatic test inhibitory rate were conducted to evaluate antibacterial ability BL. Results showed strongest role BL on C. (P < 0.05). Afterwards, 540 one-day-old yellow-feather broilers (32.7 ± 0.2 g) randomly allocated into 3 groups, including CON group (basal diet), CP diet + 1 × 10

Language: Английский

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Preclinical Evaluation of Sodium Butyrate’s Potential to Reduce Alcohol Consumption: A Dose-Escalation Study in C57BL/6J Mice in Antibiotic-Enhanced Binge-Like Drinking Model

Pharmacology, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 13

Published: Aug. 12, 2024

In our earlier efforts to establish gut-brain axis during alcohol use disorder (AUD), we have demonstrated that supplementation of C57BL/6J male mice with 8 mg/ml sodium butyrate, a major short-chain fatty acid, in drinking water reduced ethanol intake and neuroinflammatory response antibiotic (ABX)-enhanced voluntary binge-like consumption model, the dark (DID).

Language: Английский

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