Cited by Prefeeding of berberine alleviates waterborne copper-induced hepatic oxidative stress, lipid deposition, and intestinal microbiota dysbiosis in yellow catfish (Pelteobagrus fulvidraco)

Effects of Berberine on Lipid Metabolism, Antioxidant Status, and Immune Response in Liver of Tilapia (Oreochromis niloticus) under a High-Fat Diet Feeding DOI

Rui Jia, Yiran Hou, Liqiang Zhang

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(5), P. 548 - 548

Published: April 29, 2024

Berberine, a natural alkaloid found abundantly in various medicinal plants, exhibits antioxidative, anti-inflammatory, and lipid metabolism-regulatory properties. Nonetheless, its protective effects the molecular mechanisms underlying liver injury fish have not been fully elucidated. The aims of this study were to investigate metabolism-regulating berberine against high-fat diet (HFD)-induced damage clarify mechanisms. Tilapia fed diets containing two doses (50 100 mg/kg diet) alongside high fat for 60 days. results showed that treatments and/or mg/kg) significantly reduced elevated aminotransferases, triglycerides (TG), total cholesterol (TC), low-density lipoprotein (LDL-c) plasma. In liver, increased expression peroxisome proliferator-activated receptor α (pparα) carnitine palmitoyltransferase 1 (cpt-1) genes, leading reduction accumulation. Meanwhile, treatment suppressed peroxidation formation enhanced antioxidant capacity. Berberine upregulated mRNA levels erythroid 2-related factor 2 (nrf2) downstream genes including heme oxygenase (ho-1) glutathione-S-transferase (gstα). Additionally, attenuated inflammation by inhibiting toll-like (tlr2), myeloid differential protein-88 (myd88), relb, inflammatory cytokines such as interleukin-1β (il-1β), tumor necrosis factor-α (tnf-α), il-8. summary, suggested offers protection HFD-induced tilapia via regulating metabolism, status, immune response. This effect may be attributed modulation Nrf2, TLR2/MyD88/NF-κB, PPARα signaling pathways.

Language: Английский

Citations

An Investigation Into the Hepatoprotective Properties of Berberis asiatica, Withania somnifera, and Their Combination in Streptozotocin-Nicotinamide-Induced Type II Diabetes Mellitus in Wistar Rats DOI

Devkumar D Tiwari,

Vandana M Thorat,

Prathamesh V Pakale

et al.

Cureus, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 7, 2025

The rising prevalence of type II diabetes mellitus (T2DM) has increased the risk hepatic dysfunction, necessitating effective therapeutic interventions. Natural products, particularly Berberis asiatica (BA) and Withania somnifera (WS), are known for their hepatoprotective properties. This study investigates effects BA, WS, polyherbal combination in streptozotocin-nicotinamide-induced T2DM Wistar rats. Seventy-eight adult albino rats were divided into 13 groups, including normal control, disease treatment which received a (PHC) at varying doses (250, 500, 1,000 mg/kg). Metformin glimepiride served as standard treatments. Liver function was assessed through serum glutamic pyruvic transaminase (SGPT) bilirubin levels, histopathological analysis performed. Treatment with PHC significantly reduced SGPT levels compared to control (p < 0.001). demonstrated superior efficacy, higher (1,000 mg/kg) exhibiting results comparable drugs. Histopathological revealed hepatocellular damage treated indicating preserved architecture. BA individually combination, attenuated liver dysfunction diabetic synergistic effect presents promising natural approach managing diabetes-induced damage.

Language: Английский

Citations

Antioxidant and Cytotoxic Properties of <em>Berberis vulgaris</em> (L.) Stem Bark Dry Extract DOI

I. Ivan, Octavian Tudorel Olaru, Violeta Popovici

et al.

Published: April 2, 2024

Berberis vulgaris (L.) has remarkable ethnopharmacological properties and is widely used in traditional medicine. The present study investigates B. stem bark (Berberidis cortex) by extraction with 50% ethanol. main secondary metabolites were quantified, resulting a polyphenols content of 17.6780 ± 3.9320 mg Eq Tannic acid / 100 g extract, phenolic acids amount 3.3886 0.3481 Chlorogenic extract 78.95 µg/g berberine. dried hydro-ethanolic (BVE) was thoroughly analyzed using Ultra-High Performance Liquid Chromatography coupled High-Resolution Mass Spectrometry (UHPLC–HRMS/MS) HPLC 40 bioactive constituents identified. Then, the antioxidant potential BVE evaluated three methods; our results could explain protective effects Berberidis cortex EC50FRAP = 0.1398 mg/mL, IC50ABTS 0.0442 IC50DPPH 0.2610 mg/mL compared to ascorbic (IC50 0.0165 mg/mL). Next, acute toxicity teratogenicity Berberine - sulfate hydrate (BS) investigated on Daphnia sp reported significant BS after 24 h; revealed considerable 48 hours induced embryonic developmental delays. Finally, anticancer different tumor cell lines treatments. MTS assay evidenced dose- time-dependent antiproliferative activity, higher than BVE. strongest diminution viability recorded breast (MDA-MB-231), colon (LoVo) cancer, OSCC (PE/CA-PJ49) h exposure &lt; µg/mL). However, no cytotoxicity normal epithelial cells (HUVEC) hepatocellular carcinoma (HT-29) lines. Extensive data analysis supports results, showing correlation between BVE's concentration, compounds content, time, rate various cancer

Language: Английский

Citations

Antioxidant and Cytotoxic Properties of Berberis vulgaris (L.) Stem Bark Dry Extract DOI

I. Ivan, Octavian Tudorel Olaru, Violeta Popovici

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(9), P. 2053 - 2053

Published: April 29, 2024

Berberis vulgaris (L.) has remarkable ethnopharmacological properties and is widely used in traditional medicine. The present study investigated B. stem bark (Berberidis cortex) by extraction with 50% ethanol. main secondary metabolites were quantified, resulting a polyphenols content of 17.6780 ± 3.9320 mg Eq tannic acid/100 g extract, phenolic acids amount 3.3886 0.3481 chlorogenic extract 78.95 µg/g berberine. dried hydro-ethanolic (BVE) was thoroughly analyzed using Ultra-High-Performance Liquid Chromatography coupled High-Resolution Mass Spectrometry (UHPLC–HRMS/MS) HPLC, 40 bioactive constituents identified. Then, the antioxidant potential BVE evaluated three methods. Our results could explain protective effects Berberidis cortex EC50FRAP = 0.1398 mg/mL, IC50ABTS 0.0442 IC50DPPH 0.2610 mg/mL compared to ascorbic acid (IC50 0.0165 mg/mL). Next, acute toxicity teratogenicity berberine—berberine sulfate hydrate (BS)—investigated on Daphnia sp. revealed significant BS after 24 h, while considerable 48 h induced embryonic developmental delays. Finally, anticancer different tumor cell lines treatments. MTS assay evidenced dose- time-dependent antiproliferative activity, which higher for than BVE. strongest diminution viability recorded breast (MDA-MB-231), colon (LoVo) cancer, OSCC (PE/CA-PJ49) exposure < 100 µg/mL). However, no cytotoxicity reported normal epithelial cells (HUVEC) hepatocellular carcinoma (HT-29) lines. Extensive data analysis supports our results, showing correlation between concentration, compounds content, time, rate various cancer

Language: Английский

Citations

Prefeeding of berberine alleviates waterborne copper-induced hepatic oxidative stress, lipid deposition, and intestinal microbiota dysbiosis in yellow catfish (Pelteobagrus fulvidraco) DOI

Chang Gao, Lei Wang, Heng Wang

et al.

Aquaculture, Journal Year: 2024, Volume and Issue: 594, P. 741443 - 741443

Published: Aug. 3, 2024

Language: Английский

Citations