Exploration of Response Mechanisms in the Gills of Pacific Oyster (Crassostrea gigas) to Cadmium Exposure through Integrative Metabolomic and Transcriptomic Analyses

Animals, Journal Year: 2024, Volume and Issue: 14(16), P. 2318 - 2318

Published: Aug. 9, 2024

Marine mollusks, including oysters, are highly tolerant to high levels of cadmium (Cd), but the molecular mechanisms underlying their response acute Cd exposure remain unclear. In this study, Pacific oyster Crassostrea gigas was used as a biological model, exposed stress for 96 h. Transcriptomic analyses gills were performed, and metabolomic further validated these results. our total 111 differentially expressed metabolites (DEMs) 2108 genes (DEGs) identified under exposure. Further revealed alterations in key metabolic pathways associated with heavy metal response. triggered physiological responses enhanced oxidative disturbances energy metabolism, changes oysters stress. Moreover, could effectively enhance tolerance detoxification ability through activating ABC transporters, enhancing glutathione metabolism sulfur relay system gill cells, regulating metabolism. This study reveals mechanism explores by using combined metabolomics transcriptome analysis.

Language: Английский

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Insights into the potential enhanced cadmium toxicity in marine fish Centroprostis striata in the context of global warming

Marine Pollution Bulletin, Journal Year: 2025, Volume and Issue: 216, P. 118013 - 118013

Published: April 22, 2025

Language: Английский

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Comparative Transcriptome Analysis of the Hepatopancreas from Macrobrachium rosenbergii Exposed to the Heavy Metal Copper

Animals, Journal Year: 2024, Volume and Issue: 14(7), P. 1117 - 1117

Published: April 5, 2024

The contamination of aquatic ecosystems by the heavy metal copper (Cu) is an important environmental issue and poses significant risks to physiological functions organisms. Macrobrachium rosenbergii one most freshwater-cultured prawns in world. hepatopancreas crustaceans a key organ for immune defense, accumulation, detoxification, playing pivotal role toxicological research. However, research on molecular response M. Cu exposure still lacking. In this study, transcriptomic was studied after 3 48 h. Compared with control group, 11,164 (7288 up-regulated 3876 down-regulated genes) 10,937 (6630 4307 differentially expressed genes (DEGs) were identified h exposure, respectively. Most these DEGs up-regulated, implying that gene expressions largely induced Cu. Functional enrichment analysis revealed immunity, homeostasis, DNA damage repair, apoptosis regulated Seven involved metabolism selected validation qRT-PCR, results confirmed reliability RNA-Seq. All findings suggest attempts resist toxicity up-regulating expression related metabolism, detoxification. excessive accumulation reactive oxygen species (ROS), antioxidant enzyme system destroyed. As result, repair cellular stress inhibited, thereby exacerbating cell damage. order maintain normal function hepatopancreas, removes damaged cells activating mechanism. Our study not only facilitates understanding mechanisms underlying effects but also helps us identify potential biomarkers associated other crustaceans.

Language: Английский

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The cascade of cadmium toxicity: from cellular damage to pyroptotic responses in fish Channa punctatus

Fish Physiology and Biochemistry, Journal Year: 2024, Volume and Issue: 51(1), P. 1 - 16

Published: Dec. 15, 2024

Language: Английский

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Omics Technologies in Aquatic and Marine Toxicology

Published: Jan. 1, 2024

Language: Английский

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Effect of cadmium stress on gill tissues of Magallana gigas after adaptation to different light conditions

Marine Pollution Bulletin, Journal Year: 2024, Volume and Issue: 211, P. 117411 - 117411

Published: Dec. 12, 2024

Language: Английский

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