Effect of Wheat Dextrin Fiber on the Fecal Microbiome and Short-Chain Fatty Acid Concentrations in Dogs: Randomized, Single-Blinded, Parallel-Group Clinical Trial
Deleted Journal,
Journal Year:
2025,
Volume and Issue:
2(1), P. 3 - 3
Published: Jan. 17, 2025
The
purpose
of
this
study
was
to
assess
the
practical
implications
supplementing
soluble
fiber
in
diet
dogs.
Dogs
with
a
history
managed
or
active
chronic
enteropathy
were
randomized
receive
either
wheat
dextrin
(fiber
group)
maltodextrin
(placebo
mixed
food
once
daily
for
28
days.
Owners
recorded
fecal
score
one
week
prior
and
during
supplementation
period.
Shallow
shotgun
sequencing,
quantitative
PCR
abundances
core
bacterial
taxa,
short-chain
fatty
acid
(SCFA)
concentrations
via
gas
chromatography/mass
spectrometry
performed
on
samples
collected
before
after
supplementation.
Seventeen
dogs
completed
group:
nine
dogs;
placebo
eight
dogs).
change
differed
between
groups,
group
developing
softer
stools
(p
=
0.03).
Alpha
diversity,
quantified
SCFA-producing
SCFA
not
different
group.
Fecal
microbial
communities
baseline
day
groups
0.02,
respectively);
however,
size
effect
(ANOSIM
R
0.18
0.26,
respectively)
minimal.
In
small
fed
variable
commercial
diets,
additional
intake
powder
supplement
well
accepted,
but
had
minimal
discernable
clinical
benefit,
could
soften
stools.
Language: Английский
Differentiating Canine Chronic Inflammatory Enteropathies Using Faecal Amino Acid Profiles: Potential and Limitations
Animals,
Journal Year:
2025,
Volume and Issue:
15(8), P. 1185 - 1185
Published: April 21, 2025
The
aims
of
this
study
were
to
characterise
the
faecal
amino
acid
profile
dogs
with
different
chronic
digestive
diseases
(food-responsive
enteropathy
(FRE),
immunosuppressant-responsive
(IRE))
prior
dietary
change,
and
Giardia
infection
(GIA),
compared
healthy
control
(HC),
evaluate
their
discriminating
potential.
HC
group
presented
lower
tyrosine
(Tyr)
aromatic
acids
(AAAs)
FRE
or
IRE
(p
=
0.0001).
Additionally,
had
levels
threonine
(Thr)
0.0005)
than
group,
while
showed
intermediate
values.
No
statistically
significant
differences
in
observed
between
dogs.
In
contrast,
GIA
higher
values
(except
glutamic
(Glu))
other
most
determinant
variables
contributing
discriminant
functions
Tyr,
Glu,
arginine,
phenylalanine.
Validation
results
that
44%
stool
samples
misclassified,
resulting
a
56%
success
rate.
did
not
accurately
distinguish
from
dogs;
however,
excretion
AAs
was
generally
GIA.
Language: Английский
Underneath the Gut–Brain Axis in IBD—Evidence of the Non-Obvious
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(22), P. 12125 - 12125
Published: Nov. 12, 2024
The
gut–brain
axis
(GBA)
plays
a
pivotal
role
in
human
health
and
wellness
by
orchestrating
complex
bidirectional
regulation
influencing
numerous
critical
processes
within
the
body.
Over
past
decade,
research
has
increasingly
focused
on
GBA
context
of
inflammatory
bowel
disease
(IBD).
Beyond
its
well-documented
effects
GBA–enteric
nervous
system
vagus
nerve
dysregulation,
gut
microbiota
misbalance—IBD
also
leads
to
impairments
metabolic
cellular
functions:
mitochondrial
dysfunction,
cationic
transport,
cytoskeleton
dysregulation.
These
systemic
are
currently
underexplored
relation
GBA;
however,
they
crucial
for
cells’
functioning.
This
review
summarizes
studies
particular
mechanisms
IBD.
Understanding
involvement
these
may
help
find
new
therapeutic
targets
develop
approaches
improve
quality
life
IBD
patients.
Language: Английский