Novel characterisation of dairy herds in Wales: A description of principal herd typologies and antimicrobial use patterns

Preventive Veterinary Medicine, Journal Year: 2025, Volume and Issue: 238, P. 106460 - 106460

Published: Feb. 11, 2025

Antimicrobial resistance (AMR) is one of the top global public health concerns. Reducing and refining antimicrobial use (AMU) in farmed livestock vital slowing development AMR preserving efficacy antimicrobials (AMs) both humans animals. Understanding risk factors for AMU, however, crucial to informing sustainable effective farm AMU reduction prudent strategies. As a range farm-level variables are likely impact multidimensional exploratory analyses play pivotal role identifying direct indirect influencing variation typically observed between dairy herds. This study used approaches investigate whether typologies herds could be determined on basis characteristics, parameters management practices, these herd types were differentiated by AMU. was conducted 21 Wales, United Kingdom. Comprehensive surveys administered 224 usable regarding practices collated. AM sales data each as proxy Multiple correspondence analysis (MCA) hierarchical clustering principal components (HCPC) performed. The 10 dimensions yielded MCA explained 65.7 % total variance. Two data-driven herds, produced from first two cut-points HCPC dendrogram, visualised described. Here, five partitions relatively homogeneous (herd types) characterised contrasted 73 variable categories. Herd primarily constructed focused drying-off (and intramammary [IMM] AMs), size, stock purchasing culling rates addition those concerning husbandry, disease management, grazing veterinarian contact. performing blanket dry cow therapy (BDCT) higher mass IMM AMs, EMA Category C B AMs had medium (mg/PCU) compared selective (SDCT). From this help untangle myriad at level provide insight into challenges good stewardship. Strategies reductions should directed toward specific identified, such targeted interventions implement SDCT. Multivariate dimensionality invaluable elucidating when utilising high-dimensional datasets. Future prospective studies needed validate confirm causality findings.

Language: Английский

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Antimicrobial-Resistance and Virulence-Associated Genes of Pasteurella multocida and Mannheimia haemolytica Isolated from Polish Dairy Calves with Symptoms of Bovine Respiratory Disease

Microorganisms, Journal Year: 2025, Volume and Issue: 13(3), P. 491 - 491

Published: Feb. 22, 2025

Bovine respiratory disease causes significant economic losses in cattle farming due to mortality, treatment costs, and reduced productivity. It involves viral bacterial infections, with Pasteurella multocida Mannheimia haemolytica key pathogens. These bacteria contribute severe pneumonia are often found together. Poland has one of the highest levels antimicrobial use food-producing animals among European Union countries. A total 70 strains were analyzed, 48 P. 22 M. haemolytica, collected from affected calves’ tracts. The species confirmed molecularly using PCR, which was also employed detect resistance virulence-associated genes. Antimicrobial susceptibility determined broth microdilution method. varied between two studied. chlortetracycline 79.2% (38/48) oxytetracycline 81.3% (39/48), while showed 63.6% (14/22) penicillin tilmicosin. for fluoroquinolones: demonstrated 91.7% (44/48) enrofloxacin 87.5% (42/48) danofloxacin, 77.3% (17/22) susceptible both tested fluoroquinolones. tetH tetR genes observed only multocida, at frequencies 20.8% (10/48) 16.7% (8/48), respectively. Both carried mphE msrE genes, though lower frequencies. All contained lkt, gs60, gcp sodA gene, hgbB ompH present 37.5% (18/48) strains, against most commonly used antibiotics Union, although differed studied each strain exhibited presence least virulence gene.

Language: Английский

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Prevalence, antibiotic resistance, and biofilm formation of coagulase-positive staphylococci in Izmir Tulum Cheese

International Journal of Agriculture Environment and Food Sciences, Journal Year: 2025, Volume and Issue: 9(1), P. 239 - 251

Published: March 14, 2025

Coagulase-positive staphylococci (CPS) are the main causative bacterial agents of staphylococcal food intoxication, posing a significant public health risk and causing infections in humans animals. In this study, hundred Izmir Tulum Cheese samples were collected from various retail outlets province. CPS isolates cheese identified using standard cultural methods. The phenotypic antibiotic resistance was determined agar disk diffusion test method, while their biofilm formation capacity assessed colorimetric method. isolated 30 out 100 analyzed (30%), it that 27 these (27%) had levels exceeding maximum acceptable limit 10³ CFU/g set by Turkish Food Codex Microbiological Criteria Regulation. Antimicrobial analysis revealed among isolates, 90% resistant to penicillin, rates other commonly used antibiotics 83.3% for clindamycin, 56.7% ciprofloxacin, 53.3% tetracycline. Additionally, 76.7% multidrug-resistant, meaning they not easily killed different antibiotics, which limits treatment options. Furthermore, formation, highlighting its impact on safety. These findings emphasize need stricter hygiene protocols, controlled use, innovative strategies combat biofilms dairy production.

Language: Английский

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Phage Isolation, Characterization, and Antibiotic Resistance Profiling in Avian Pathogenic Escherichia coli: Integrating Data for a Possible Novel AMR Surveillance Model

Microbial Pathogenesis, Journal Year: 2025, Volume and Issue: unknown, P. 107506 - 107506

Published: March 1, 2025

Language: Английский

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Nutritional Strategies to Alleviate Stress and Improve Welfare in Dairy Ruminants

Animals, Journal Year: 2024, Volume and Issue: 14(17), P. 2573 - 2573

Published: Sept. 4, 2024

Dairy ruminants provide a major part of the livestock and agriculture sectors. Due to increase in world population subsequent dairy product demands, sector has been intensified. farming intensification animal nutritional demands average global temperature as well have subjected animals various stress conditions that impact their health welfare. Various management practices strategies proposed studied alleviate these impacts, especially under heat stress, during critical periods, like transition period. Some interventions cope with factors ensure optimal production are inclusion functional fatty acids amino feed additives (minerals, prebiotics, probiotics, essential oils herbs, phytobiotics, enzymes, etc.) proven regulate animals’ metabolism improve antioxidant status immune function. Thus, could be key ensuring optimum growth, milk production, reproduction efficiency. This review summarizes highlights approaches support remarkable metabolic adaptations facing period reduce effects evaluate beneficial on physiology, performance, health,

Language: Английский

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Climate Change, Land Use, and the Decline in Traditional Fulani Cattle Practices: Drivers of Antimicrobial Resistance in Kwara, Nigeria

Challenges, Journal Year: 2024, Volume and Issue: 15(4), P. 41 - 41

Published: Oct. 21, 2024

This paper presents a case study of Fulani herdsmen in Nigeria, whose traditional ethnoveterinary practices risk being lost as the country transitions to more intensive and enclosed livestock practices. We use planetary health framing make visible value indigenous that are less damaging environment, animal welfare, human health. Through ethnographic observation, focus group discussions (FGDs), key stakeholder interviews, we show complex system herbal medicines herding maintain herd health, manage treat disease when it arises. However, their traditions often sit uncomfortably with commercial farming As grazing lands eroded, dispossessed take employment from businessmen farmers. Both parties’ inexperience shed hygiene, artificial feed, environmentally resilient crossbreeds leads an increased incidence infectious disease. This, turn, drives higher antibiotics. There is, thus, ‘causal chain’ underlying drivers lead, through poorer environmental, animal, The antibiotic resistance emerges this chain threatens now future. framing, advocate for deeper understanding knowledge held by alternative increasing (ABU).

Language: Английский

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Antimicrobial Resistance and Virulence-Associated Genes of Pasteurella multocida and Mannheimia haemolytica Isolated from Polish Dairy Calves with Symptoms of Bovine Respiratory Disease

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 25, 2024

Abstract Background Bovine respiratory disease causes significant economic losses in cattle farming due to mortality, treatment costs, and reduced productivity. It involves viral bacterial infections, with Pasteurella multocida ( P. ) Mannheimia haemolytica M. as key pathogens. These bacteria contribute severe pneumonia are often found together. A total of 70 strains were analysed: 48 22 , collected from deep nasal swabs or lung bronchial affected calves. The species confirmed molecularly using PCR, which was also employed detect antimicrobial resistance virulence-associated genes. Antimicrobial susceptibility determined the broth microdilution method. Results varied between two studied. highest observed chlortetracycline 79.2% oxytetracycline 81.3%, while showed 63.6% penicillin tilmicosin. Multidrug among 27.1%, it reached 40.9%. most commonly phenotypic patterns ‘chlortetracycline, oxytetracycline’ 37.5% ‘ceftiofur, chlortetracycline, oxytetracycline, penicillin, tilmicosin, tulathromycin’ 18.2% . for fluoroquinolones: demonstrated 91.7% enrofloxacin, 77.3% susceptible both enrofloxacin danofloxacin. detected 31.4% all tested strains. MIC 50 90 determinations performed antimicrobials. All contained lkt, gs60 gcp carried sodA gene, hgbB ompH genes present 20.8% strains, respectively. tetH tetR only at frequencies 16.7%, Both mphE msrE genes, though lower 6.3% 14.6%. Conclusions This study expands knowledge pathogenicity dairy exhibited tetracyclines, greatest nonsusceptibility penicillin. be fluoroquinolones. One third multidrug resistance.

Language: Английский

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Factors Affecting Milk Productivity, Milk Quality and Dairy Cow Health

Animals, Journal Year: 2024, Volume and Issue: 14(24), P. 3707 - 3707

Published: Dec. 23, 2024

Milk and dairy products are considered important sources of nutrients in human nutrition due to their content high-quality protein, minerals, vitamins, energy [...]

Language: Английский

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