Missense Mutations in FDNC5 Associated with Morphometric Traits and Meat Quality in Hainan Black Goats DOI Creative Commons
Jing Huang,

Mengning Xu,

Yuelang Zhang

et al.

Animals, Journal Year: 2025, Volume and Issue: 15(4), P. 565 - 565

Published: Feb. 15, 2025

Goats are widely recognized for their adaptability and resource efficiency, making them an excellent choice sustainable farming. However, the Hainan Black goat (HNBG), a vital breed in southern China's tropical regions, faces significant challenges that threaten its productivity economic viability. Specifically, young HNBGs exhibit stunted growth poor muscle development, indicating may have more genetic defects cause phenotypes. The FNDC5 gene, which encodes protein irisin, plays key role promoting mitochondrial biogenesis oxidative metabolism by activating critical signaling molecules such as PGC-1α, thereby enhancing endurance metabolic efficiency. This study aimed to investigate impact of missense mutations gene on meat quality traits HNBGs. We sequenced population identified three SNPs could lead amino acid substitutions. Notably, SNP1 (p.119A/V) SNP2 (p.135R/H) showed strong linkage. Predictions structural effects these indicated SNP3 (p.170W/G) alter secondary structure protein. Association analyses revealed were significantly associated with morphometric quality. phenotypic values co-mutants lower than those other combined genotypes. Furthermore, expression levels varied notably across individuals different These findings suggest FNDC5-SNP1 serve promising marker selecting improved offering potential pathway this breed.

Language: Английский

Missense Mutations in FDNC5 Associated with Morphometric Traits and Meat Quality in Hainan Black Goats DOI Creative Commons
Jing Huang,

Mengning Xu,

Yuelang Zhang

et al.

Animals, Journal Year: 2025, Volume and Issue: 15(4), P. 565 - 565

Published: Feb. 15, 2025

Goats are widely recognized for their adaptability and resource efficiency, making them an excellent choice sustainable farming. However, the Hainan Black goat (HNBG), a vital breed in southern China's tropical regions, faces significant challenges that threaten its productivity economic viability. Specifically, young HNBGs exhibit stunted growth poor muscle development, indicating may have more genetic defects cause phenotypes. The FNDC5 gene, which encodes protein irisin, plays key role promoting mitochondrial biogenesis oxidative metabolism by activating critical signaling molecules such as PGC-1α, thereby enhancing endurance metabolic efficiency. This study aimed to investigate impact of missense mutations gene on meat quality traits HNBGs. We sequenced population identified three SNPs could lead amino acid substitutions. Notably, SNP1 (p.119A/V) SNP2 (p.135R/H) showed strong linkage. Predictions structural effects these indicated SNP3 (p.170W/G) alter secondary structure protein. Association analyses revealed were significantly associated with morphometric quality. phenotypic values co-mutants lower than those other combined genotypes. Furthermore, expression levels varied notably across individuals different These findings suggest FNDC5-SNP1 serve promising marker selecting improved offering potential pathway this breed.

Language: Английский

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