Harnessing Nanotechnology to Enhance Essential Oil Applications

Molecules, Journal Year: 2025, Volume and Issue: 30(3), P. 520 - 520

Published: Jan. 24, 2025

Essential oils (EOs) are versatile natural compounds with significant antimicrobial, antioxidant, antifungal, and therapeutic properties, making them valuable in industries such as food preservation, agriculture, healthcare. However, their inherent volatility, low water solubility, susceptibility to environmental degradation limit direct applications. Nanotechnology offers transformative solutions these challenges, enhancing the stability, bioavailability, efficacy of EOs through innovative nano systems emulsions, encapsulations, nanocomposites. This study explores integration nanotechnology essential oils, emphasizing advanced preparation techniques, physicochemical diverse It highlights sustainable approaches, including eco-friendly synthesis biodegradable carriers, which align global trends toward green chemistry. By addressing key challenges proposing future directions, this research underscores potential EO deliver multifunctional environmentally conscious for security, antimicrobial resistance, agriculture.

Language: Английский

Neem Oil (Azadirachta indica L.) Response Surface Methodology (RSM)-Optimized Nanoemulsions for Sensory Quality Preservation of Oreochromis niloticus Fillets

Biology, Journal Year: 2025, Volume and Issue: 14(4), P. 400 - 400

Published: April 10, 2025

Neem oil nanoemulsions (NO NEs) have gained attention as natural antibacterial agents due to toxicity concerns surrounding synthetic preservatives. This study aimed prepare a response surface methodology (RSM)-optimized NO NE < 200 nm achieve stable dip solution maintain the sensory quality of Oreochromis niloticus fillets. The achieved formulation with particle size 160.2 ± 0.04 on average. polydispersity index (PDI) was 0.1 0.05, and zeta potential found be 18.2 0.09 mV. Gas chromatography confirmed presence nimbiol, nimbandiol, 6-deacetyl nimbinene, azadirachtin in after ultrasonic homogenization for 10 min (alternating between 30 s rest work time). had spherical shape smooth surface, evident from transmission electron microscopy (TEM). Furthermore, NO:PM (neem oil–potassium metabisulphite) an MIC (minimum inhibitory concentration) value 150 ppm, compared 210 ppm alone, against Staphylococcus aureus. Time–kill dynamics revealed more effective control S. aureus until 72 h NO:PM. Moreover, DNA protein leakage also increased 0.145 0.001 0.769 0.002 OD (optical density) 0.142 0.740 OD, respectively, co-formulation Conclusively, inhibited at lower dose alone. complete inhibition vitro period h. On other hand, proximate analysis O. fillets showed no alteration pH, loss, juiciness/moisture retention during days storage (4 °C). Sensory panelists reported that treated improved color, flavor, juiciness, aroma, overall quality. These results show is suitable green preservative fish possibly meat-based products.

Language: Английский

Molecular Docking of Key Compounds from Acacia Honey and Nigella sativa Oil and Experimental Validation for Colitis Treatment in Albino Mice

Biology, Journal Year: 2024, Volume and Issue: 13(12), P. 1035 - 1035

Published: Dec. 11, 2024

Colitis, an inflammatory condition of the colon that encompasses ulcerative colitis (UC) and Crohn's disease, presents significant challenges due to limitations side effects current treatments. This study investigates potential natural products, specifically AH NSO, as organic therapeutic agents for colitis. Molecular docking studies were conducted identify binding affinities interaction mechanisms between bioactive compounds in NSO proteins implicated colitis, such those involved inflammation oxidative stress pathways. An vivo experiment was performed using albino mouse model with clinical symptoms, histopathological assessments, biochemical analyses evaluate both individually combination. Results from molecular revealed promising interactions fructose Prostaglandin G/H synthase 2 (Ptgs2) cellular tumor antigen p53, energy measured at -6.0 kcal/mol -5.1 kcal/mol, respectively. Meanwhile, presence glucose molecule glucokinase chain A (-6.3 kcal/mol) B (-5.8 indicated efficacy modulating Experimental data demonstrated treatment significantly reduced inflammation, improved gut health, ameliorated symptoms. Histopathological evaluations confirmed mucosal damage immune cell infiltration, while showed normalization markers levels. provides compelling evidence natural, complementary treatments suggesting their future role integrative strategies. However, further research into long-term safety, optimal dosing, action is warranted translate these findings applications.

Language: Английский