Human and Veterinary Medicine Collaboration: Synergistic Approach to Address Antimicrobial Resistance Through the Lens of Planetary Health

Antibiotics, Journal Year: 2025, Volume and Issue: 14(1), P. 38 - 38

Published: Jan. 6, 2025

Antimicrobial resistance (AMR) represents a critical threat to human, animal, and environmental health, challenging global efforts maintain sustainable ecosystems public health systems. In this review, the complex, cross-disciplinary issues of AMR are explored within framework planetary emphasizing interconnectedness human veterinary medicine with broader social Specifically, it addresses social, economic, environmental, dimensions under framework. The aspects consider how awareness, education, healthcare practices shape antimicrobial use (AMU) patterns. economic impact evaluates cost burdens AMR, including costs, loss productivity, implications for livestock food production industries. dimension highlights role pharmaceutical waste, agricultural runoff, industrial pollution in contributing spread antimicrobials resistant pathogens ecosystems. To illustrate these challenges, comprehensive literature review using PubMed Web Science databases was conducted, identifying 91 relevant articles on AMR. knowledge from studies additional references is integrated provide holistic overview crisis. By applying four pillars health-social, knowledge-in manuscript, necessity underscored collaborative strategies across combat Ultimately, synergistic approach aims policies that safeguard protect ecosystems, promote future by implementing stewardship programs encouraging prudent AMU.

Language: Английский

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Antimicrobial and Antibiofilm Activity of Chitosan Nanoparticles Against Staphylococcus aureus Strains Isolated from Bovine Mastitis Milk

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(2), P. 186 - 186

Published: Feb. 2, 2025

Background/Objectives: Bovine mastitis (BM), a prevalent and economically burdensome bacterial infection affecting dairy cattle, poses significant challenge to the industry. The traditional approach combating BM, relying heavily on antibiotics, faces growing concerns due increasing antibiotic resistance exhibited by pathogens. objective of this study was evaluate determine antimicrobial anti-biofilm potential chitosan nanoparticles (NQo) S. aureus strains isolated from milk samples obtained areas in southern Chile cows diagnosed with BM. Methods: NQo were synthesized using ionotropic gelation method thoroughly characterized transmission electron microscopy (TEM) dynamic light scattering (DLS). Results: exhibit robust positive charge (Z-potential +55.4 ± 2.5 mV) an exceptionally small size (20.3 3.2 nm). This unique combination properties makes particularly well-suited for targeting interacting To assess effectiveness against we conducted series experiments Staphylococcus strain BM Chile. demonstrated remarkable ability inhibit proliferation effectively modulate biofilm formation strains. Furthermore, performance comparison established antibiotics like ampicillin gentamicin strongly suggests that these hold immense as attractive alternative control, prevention, and/or treatment Conclusions: both antibiofilm activity clinically relevant pathogen. Further investigations are necessary develop hydrogel formulation optimized effective delivery target diseased tissue.

Language: Английский

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Antimicrobial-Resistance and Virulence-Associated Genes of Pasteurella multocida and Mannheimia haemolytica Isolated from Polish Dairy Calves with Symptoms of Bovine Respiratory Disease

Microorganisms, Journal Year: 2025, Volume and Issue: 13(3), P. 491 - 491

Published: Feb. 22, 2025

Bovine respiratory disease causes significant economic losses in cattle farming due to mortality, treatment costs, and reduced productivity. It involves viral bacterial infections, with Pasteurella multocida Mannheimia haemolytica key pathogens. These bacteria contribute severe pneumonia are often found together. Poland has one of the highest levels antimicrobial use food-producing animals among European Union countries. A total 70 strains were analyzed, 48 P. 22 M. haemolytica, collected from affected calves’ tracts. The species confirmed molecularly using PCR, which was also employed detect resistance virulence-associated genes. Antimicrobial susceptibility determined broth microdilution method. varied between two studied. chlortetracycline 79.2% (38/48) oxytetracycline 81.3% (39/48), while showed 63.6% (14/22) penicillin tilmicosin. for fluoroquinolones: demonstrated 91.7% (44/48) enrofloxacin 87.5% (42/48) danofloxacin, 77.3% (17/22) susceptible both tested fluoroquinolones. tetH tetR genes observed only multocida, at frequencies 20.8% (10/48) 16.7% (8/48), respectively. Both carried mphE msrE genes, though lower frequencies. All contained lkt, gs60, gcp sodA gene, hgbB ompH present 37.5% (18/48) strains, against most commonly used antibiotics Union, although differed studied each strain exhibited presence least virulence gene.

Language: Английский

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A focus group study exploring necessary competencies and contextual factors for effective antimicrobial stewardship on dairy farms

Journal of Dairy Science, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

There is a need for improved antimicrobial stewardship on dairy farms, and changes will be largely enacted by farm workers who are responsible carrying out procedures. For this reason, efforts directed at educating enabling in necessary compliance with farm-level usage policies. Therefore, the objectives of research were: 1) to determine competencies needed implement inform educational resource development 2) explore contexts that influence worker capabilities. Initially, focus group discussions were conducted in-person 6 groups veterinarians 3 independent conferences held United States. To gain additional perspectives, 2 via video link producers from Midwestern The had 4-8 participants 4 facilitators each, audio recorded transcribed analysis. Discussions recorded, transcribed, evaluated using inductive thematic analysis, 9 key themes identified. Participants emphasized willing learn, responsible, consistent their execution tasks. Furthermore, knowledge about rationale behind use strategies disease mitigation practices. General skills included good communication, excellent observation, ability follow protocols keep records, technical required related handling animals, attention cleanliness, properly administer pharmaceutical product, equipment maintenance. differed among depending responsibilities experience, greater expectations herd managers as compared employees specialized specific task such milking. Farm impacted size, which other themes: workplace culture, leadership, tools. Workplace culture encompassed having an approachable environment clear responsibilities, while leadership managerial capacity veterinary support. Important tools effective relevant up date protocols, technology, equipment, proficient workforce. evidence provided through these useful informing competency-based aimed improving farms.

Language: Английский

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Prevalence, antibiotic resistance, and biofilm formation of coagulase-positive staphylococci in Izmir Tulum Cheese

International Journal of Agriculture Environment and Food Sciences, Journal Year: 2025, Volume and Issue: 9(1), P. 239 - 251

Published: March 14, 2025

Coagulase-positive staphylococci (CPS) are the main causative bacterial agents of staphylococcal food intoxication, posing a significant public health risk and causing infections in humans animals. In this study, hundred Izmir Tulum Cheese samples were collected from various retail outlets province. CPS isolates cheese identified using standard cultural methods. The phenotypic antibiotic resistance was determined agar disk diffusion test method, while their biofilm formation capacity assessed colorimetric method. isolated 30 out 100 analyzed (30%), it that 27 these (27%) had levels exceeding maximum acceptable limit 10³ CFU/g set by Turkish Food Codex Microbiological Criteria Regulation. Antimicrobial analysis revealed among isolates, 90% resistant to penicillin, rates other commonly used antibiotics 83.3% for clindamycin, 56.7% ciprofloxacin, 53.3% tetracycline. Additionally, 76.7% multidrug-resistant, meaning they not easily killed different antibiotics, which limits treatment options. Furthermore, formation, highlighting its impact on safety. These findings emphasize need stricter hygiene protocols, controlled use, innovative strategies combat biofilms dairy production.

Language: Английский

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INVITED REVIEW: Mastitis Escherichia coli strains: Mastitis-Associated or Mammo-Pathogenic ?

Journal of Dairy Science, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

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From tradition to precision: leveraging digital tools to improve cattle health and welfare

Frontiers in Veterinary Science, Journal Year: 2025, Volume and Issue: 12

Published: April 2, 2025

Traditional cattle production practices relied heavily on manual observation and empirical decision-making, often leading to inconsistent outcomes. In contrast, modern approaches leverage technology achieve greater precision efficiency. Advancement in has shifted a new dimension of predictive monitoring health management. This review aims at highlighting the available current digital technologies health, evaluate their utility practice, identify possible future advancements field that can potentially bring even more changes this industry. The paper highlights some barriers disadvantages using these technologies, such as data security issues, high capital investments, skills gap. integration advanced is set play fundamental role enabling livestock industry meet rising global demand for high-quality, sustainably produced products. These are essential ensuring compliance with ethical standards best care well-being. light advancements, application innovations will support achievement socially responsible production, while simultaneously maintaining optimal levels animal welfare.

Language: Английский

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Identification of Naturally Occurring Inhabitants of Vaginal Microbiota in Cows and Determination of Their Antibiotic Sensitivity

Veterinary Sciences, Journal Year: 2025, Volume and Issue: 12(5), P. 423 - 423

Published: April 29, 2025

The vaginal microbiota plays a crucial role in bovine reproductive health the periparturient period. This study aimed to characterize naturally occurring bacterial species microbiome of healthy Holstein Frisian cows and evaluate their antibiotic sensitivity. Vaginal samples were collected from 44 on three dairy farms. A total 54 detected, with Gram-positive bacteria comprising 87% isolates. most prevalent genera Bacillus, Streptococcus, Staphylococcus. Antibiotic susceptibility tests indicated that some isolates carried resistance genes, but remained sensitive commonly used antibiotics. average mucosa pH was 7.2. These findings provide valuable insights into diversity cows. Understanding composition can support management prudent use antibiotics herds.

Language: Английский

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Precision livestock farming in the 21st century: Challenges and opportunities for sustainable agriculture

CABI Reviews, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 8, 2024

Abstract This study aimed to review the recent development of different technologies in precision livestock farming (PLF), along with their scopes and challenges. PLF is an innovative, contemporary, fast-expanding approach agriculture that aims improve sustainable farming. The growing global population has increased demand for animal products. To meet this demand, farmers have increase production, so without integration technology, cannot be achieved. currently employs a variety technologies. Some these methods include vision-based solutions, load cells, accelerometers, microphones, thermal cameras, photoelectric sensors, radio-frequency identification (RFID). Despite availability technologies, adoption by varies widely on basis cost investment, ease operation, availability, accessibility. These are used track activities farming, such as feeding, drinking, physical behavior, temperature regulation, tracking identification, estrus detection, disease milking. contributes significantly technological advancement, human-animal relationships, environmental sustainability, productivity. It does, however, present number obstacles eventual advantages.

Language: Английский

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Antimicrobial Resistance and Virulence-Associated Genes of Pasteurella multocida and Mannheimia haemolytica Isolated from Polish Dairy Calves with Symptoms of Bovine Respiratory Disease

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 25, 2024

Abstract Background Bovine respiratory disease causes significant economic losses in cattle farming due to mortality, treatment costs, and reduced productivity. It involves viral bacterial infections, with Pasteurella multocida ( P. ) Mannheimia haemolytica M. as key pathogens. These bacteria contribute severe pneumonia are often found together. A total of 70 strains were analysed: 48 22 , collected from deep nasal swabs or lung bronchial affected calves. The species confirmed molecularly using PCR, which was also employed detect antimicrobial resistance virulence-associated genes. Antimicrobial susceptibility determined the broth microdilution method. Results varied between two studied. highest observed chlortetracycline 79.2% oxytetracycline 81.3%, while showed 63.6% penicillin tilmicosin. Multidrug among 27.1%, it reached 40.9%. most commonly phenotypic patterns ‘chlortetracycline, oxytetracycline’ 37.5% ‘ceftiofur, chlortetracycline, oxytetracycline, penicillin, tilmicosin, tulathromycin’ 18.2% . for fluoroquinolones: demonstrated 91.7% enrofloxacin, 77.3% susceptible both enrofloxacin danofloxacin. detected 31.4% all tested strains. MIC 50 90 determinations performed antimicrobials. All contained lkt, gs60 gcp carried sodA gene, hgbB ompH genes present 20.8% strains, respectively. tetH tetR only at frequencies 16.7%, Both mphE msrE genes, though lower 6.3% 14.6%. Conclusions This study expands knowledge pathogenicity dairy exhibited tetracyclines, greatest nonsusceptibility penicillin. be fluoroquinolones. One third multidrug resistance.

Language: Английский

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