Combining Cold Atmospheric Plasma and Environmental Nanoparticle Removal Device Reduces Neurodegenerative Markers DOI Open Access
Nerea Menéndez-Coto, Claudia García-González,

Francisco Javier Baena-Huerta

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(23), P. 12986 - 12986

Published: Dec. 3, 2024

Ageing leads to a gradual deterioration of the organs, with brain being particularly susceptible, often leading neurodegeneration. This process includes well-known changes such as tau hyperphosphorylation and beta-amyloid deposition, which are commonly associated neurodegenerative diseases but also present in ageing. These structures triggered by earlier cellular energy depletion impaired protein synthesis, both essential for cell function. may part be induced environmental pollution, has been shown accelerate these processes. Cold Atmospheric Plasma (CAP) or atmospheric pressure gas discharge plasmas have promise activating immune system improving function vitro, although their effects at organ level remain poorly understood. Our aim this work is investigate effect device that combines CAP treatment effective removal nanoparticles, typical products on activity aged mouse brains. The results showed an increase capacity, reduction reticulum stress activation autophagic clearance, minimising aggresomes brain. key markers neurodegeneration demonstrating efficacy tested product level.

Language: Английский

Analyzing the Clinical Potential of Cold Atmospheric Plasma in Dentistry as an Alternative to Antibiotic Therapy. Comment on Gross et al. Guided Plasma Application in Dentistry—An Alternative to Antibiotic Therapy. Antibiotics 2024, 13, 735 DOI Creative Commons
Thibault Canceill, Cristina Canal, Antoine Dubuc

et al.

Antibiotics, Journal Year: 2025, Volume and Issue: 14(3), P. 272 - 272

Published: March 7, 2025

The study by Gross et al [...]

Language: Английский

Citations

1
Reply to Canceill et al. Analyzing the Clinical Potential of Cold Atmospheric Plasma in Dentistry as an Alternative to Antibiotic Therapy. Comment on “Gross et al. Guided Plasma Application in Dentistry—An Alternative to Antibiotic Therapy. Antibiotics 2024, 13, 735” DOI Creative Commons

Tara Groß,

Loïc Ledernez,

Laurent Birrer

et al.

Antibiotics, Journal Year: 2025, Volume and Issue: 14(3), P. 327 - 327

Published: March 20, 2025

Thank you for your interest and thoughtful comment on our paper “Guided Plasma Application in Dentistry—An Alternative to Antibiotic Therapy” [...]

Language: Английский

Citations

0
The Hormetic Adaptative Capacity and Resilience to Oxidative Stress Is Strengthened by Exposome Enrichment with Air Cold Atmospheric Plasma: A Metabolome Targeted Follow-Up Approach DOI Creative Commons
Lucía González-Llorente, Miguel Ángel Andrés Gasco, Miguel Aranda

et al.

Biomedicines, Journal Year: 2025, Volume and Issue: 13(4), P. 949 - 949

Published: April 12, 2025

Background/Objectives: The exposome, encompassing all environmental influences on health, plays a pivotal role in oxidative stress-related diseases. Negative air ions (NAIs), generated via cold atmospheric plasma (CAP), have been proposed as potential modulators of resilience. This study aims to investigate the metabolic adaptations induced by prolonged exposure an NAI-enriched environment mice, focusing its effects stress markers and energy metabolism liver blood. Methods: Twenty male C57BL/6J mice were divided into four groups: two experimental groups exposed Air Cold Atmospheric Plasma–Nanoparticle Removal (aCAP-NR) device for either 18 days (short-term, ST) or 28 (long-term, LT), control without exposure. Targeted metabolomics was performed whole blood using ultra-high-performance liquid chromatography–mass spectrometry (UHPLC-MS). Statistical pathway analyses conducted assess alterations. Results: Metabolic profiling revealed significant shifts pathways, including enhanced glutathione metabolism, reduced lipid peroxidation, modulation purine metabolism. Short-term led increased mitochondrial efficiency homeostasis, while long-term adaptive reprogramming, with higher inosine levels suggesting antioxidant anti-inflammatory responses. No adverse systemic hepatic health observed. Conclusions: NAI aCAP-NR elicits hormetic response, enhancing resilience stress. These findings suggest that controlled enrichment NAIs may serve novel non-invasive strategy mitigating damage improving adaptative capacity stress, warranting further translational research.

Language: Английский

Citations

0
Combining Cold Atmospheric Plasma and Environmental Nanoparticle Removal Device Reduces Neurodegenerative Markers DOI Open Access
Nerea Menéndez-Coto, Claudia García-González,

Francisco Javier Baena-Huerta

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(23), P. 12986 - 12986

Published: Dec. 3, 2024

Ageing leads to a gradual deterioration of the organs, with brain being particularly susceptible, often leading neurodegeneration. This process includes well-known changes such as tau hyperphosphorylation and beta-amyloid deposition, which are commonly associated neurodegenerative diseases but also present in ageing. These structures triggered by earlier cellular energy depletion impaired protein synthesis, both essential for cell function. may part be induced environmental pollution, has been shown accelerate these processes. Cold Atmospheric Plasma (CAP) or atmospheric pressure gas discharge plasmas have promise activating immune system improving function vitro, although their effects at organ level remain poorly understood. Our aim this work is investigate effect device that combines CAP treatment effective removal nanoparticles, typical products on activity aged mouse brains. The results showed an increase capacity, reduction reticulum stress activation autophagic clearance, minimising aggresomes brain. key markers neurodegeneration demonstrating efficacy tested product level.

Language: Английский

Citations

1