Antimicrobial Peptide Delivery Systems as Promising Tools Against Resistant Bacterial Infections DOI Creative Commons
Kamila Botelho Sampaio de Oliveira, Michel Lopes Leite,

Nadielle Tamires Moreira Melo

et al.

Antibiotics, Journal Year: 2024, Volume and Issue: 13(11), P. 1042 - 1042

Published: Nov. 4, 2024

The extensive use of antibiotics during recent years has led to antimicrobial resistance development, a significant threat global public health. It is estimated that around 1.27 million people died worldwide in 2019 due infectious diseases caused by antibiotic-resistant microorganisms, according the WHO. 700,000 die each year worldwide, which expected rise 10 2050. Therefore, new and efficient antimicrobials against resistant pathogenic bacteria are urgently needed. Antimicrobial peptides (AMPs) present broad spectrum antibacterial effects considered potential tools for developing novel therapies combat infections. However, their clinical application currently limited instability, low selectivity, toxicity, bioavailability, resulting narrow therapeutic window. Here we describe an overview AMPs bacterial infections through nanoformulation. evaluates metal, polymeric, lipid AMP delivery systems as promising treatment infections, offering solution aforementioned limitations.

Language: Английский

Future applications of cyclic antimicrobial peptides in drug delivery DOI

Dorna Davani-Davari,

Rakesh K. Tiwari, Keykavous Parang

et al.

Expert Opinion on Drug Delivery, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

Cyclic antimicrobial peptides (CAMPs) are gaining attention as promising candidates in advanced drug delivery systems due to their structural stability, resistance proteolytic degradation, and versatile therapeutic potential. Their unique properties enable applications that extend beyond combating multidrug-resistant (MDR) pathogens. amphipathic cell-penetrating allow them efficiently transport drugs across cellular membranes. This review explores the advantages mechanisms of action CAMPs, emphasizing role delivery. The literature analysis (2010-2024) from PubMed, Scopus, Web Science highlights developments CAMP-conjugated therapies, liposomal formulations, encapsulation systems. also examines potency, properties, integration into nanocarrier technologies enhance bioavailability, precision targeting. Challenges such toxicity, scalability, cost discussed. CAMPs have potential revolutionize through robustness multifunctionality, particularly medicine. Future advancements peptide engineering, nanotechnology, AI-driven design expected CAMPs' specificity, reduce broaden applications, including oncology gene therapy, paving way for next-generation therapeutics.

Language: Английский

Citations

0
Mechanisms, therapeutic strategies, and emerging therapeutic alternatives for carbapenem resistance in Gram-negative bacteria DOI

Fatima Mourabiti,

Fatimazahra Jouga,

Souraya Sakoui

et al.

Archives of Microbiology, Journal Year: 2025, Volume and Issue: 207(3)

Published: Feb. 13, 2025

Language: Английский

Citations

0
High prevalence of plasmid-mediated Fosfomycin resistance in waterfowl-derived Escherichia coli strains: insights into genetic context and transmission dynamics in China DOI Creative Commons

Shaqiu Zhang,

Jing Yang, Qian Yang

et al.

Frontiers in Veterinary Science, Journal Year: 2025, Volume and Issue: 12

Published: March 21, 2025

Fosfomycin (FOS) is a critical antibiotic for treating multi-drug resistant (MDR) Enterobacteriaceae infections, but its effectiveness jeopardized by the dissemination of plasmids encoding enzymes that modify FOS. Despite prohibition on use in animal breeding China, 100 strains Escherichia coli ( E. ) exhibiting high resistance to FOS (MIC≥512 mg/L) were isolated from samples waterfowl origin collected Hainan, Sichuan, and Anhui. These commonly carried fos A 3 (88/100, 88.0%). In addition, 21 other antimicrobial genes (ARGs) detected these strains, with positivity rates tet A, aphA1 , sul2 folR qnrS bla CTX-M . It noteworthy there was significant positive correlation between A3 (OR = 15.162, 95% CI: 1.875–122.635). The results pulsed-field gel electrophoresis (PFGE) demonstrated existence multiple dispersed clonal clusters. Multilocus sequence typing (MLST) analysis identified 45 ST types, ST48 ST10 representing most dominant clones. conjugation experiments, 53 A-like transconjugants obtained measurable frequency, which strongly may mainly locate different types possessing an efficient transmission ability. Whole genome sequencing (WGS) further showed co-localized degree similarity genetic structure. Of particular interest observation frequently accompanied IS 26 either side gene. This structure play pivotal role horizontal transfer A3. study revealed alarming prevalence delved deeply into characteristics mechanisms discovery plasmid-mediated, transmissible poses threat “One Health”. There’s urgent need thorough monitoring control measures against resistance.

Language: Английский

Citations

0
Highly antibacterial and biocompatible polylysine-modified silk fibroin for potential food preservation and biomedical applications DOI
Ying Mao, Xinmei Liu, Lili Xin

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 143130 - 143130

Published: April 1, 2025

Language: Английский

Citations

0
Antimicrobial Peptide Delivery Systems as Promising Tools Against Resistant Bacterial Infections DOI Creative Commons
Kamila Botelho Sampaio de Oliveira, Michel Lopes Leite,

Nadielle Tamires Moreira Melo

et al.

Antibiotics, Journal Year: 2024, Volume and Issue: 13(11), P. 1042 - 1042

Published: Nov. 4, 2024

The extensive use of antibiotics during recent years has led to antimicrobial resistance development, a significant threat global public health. It is estimated that around 1.27 million people died worldwide in 2019 due infectious diseases caused by antibiotic-resistant microorganisms, according the WHO. 700,000 die each year worldwide, which expected rise 10 2050. Therefore, new and efficient antimicrobials against resistant pathogenic bacteria are urgently needed. Antimicrobial peptides (AMPs) present broad spectrum antibacterial effects considered potential tools for developing novel therapies combat infections. However, their clinical application currently limited instability, low selectivity, toxicity, bioavailability, resulting narrow therapeutic window. Here we describe an overview AMPs bacterial infections through nanoformulation. evaluates metal, polymeric, lipid AMP delivery systems as promising treatment infections, offering solution aforementioned limitations.

Language: Английский

Citations

1