The Impact of the COVID-19 Pandemic on Pediatric Microbial Resistance Patterns and Abandonment Rates in Western Romania—An Interdisciplinary Study DOI Creative Commons
Dan Dumitru Vulcănescu, Iulia Cristina Bagiu,

Tiberiu Liviu Dragomir

et al.

Antibiotics, Journal Year: 2025, Volume and Issue: 14(4), P. 411 - 411

Published: April 16, 2025

Background: The COVID-19 pandemic in Romania exacerbated pediatric antimicrobial resistance (AMR). Overuse of broad-spectrum antibiotics may be related to increased multidrug-resistant bacteria. main aim this study was assess AMR trends and phenotypes, while a secondary objective investigate the potential links with hospital abandonment. Methods: This retrospective from Children’s Emergency Hospital “Louis Țurcanu”, Timișoara, focused on patterns 2019 pre-pandemic, 2021 pandemic, 2023 post-pandemic. following phenotypes were assessed: MRSA, MRCoNS, VRE, ESBL, CRO, MDR, XDR, PDR. Results: There 3530 total patients 6885 samples. 69.92% samples resistant at least one class, (72.69% 2019, 67.05% 2021, 69.16% 2023). Specifically, towards penicillins remained high across entire period (57.45–60.93%), classes presented elevated pandemic: cephalosporins (42.91%), combination therapies (40.95%), reserve (38.89%), cyclines (13.83%). As for MRSA MRCoNS peaked during (36.08% 81.43%, respectively) VRE relatively constant. Overall ESBL declined 14.45%, overall CRO (8.81%). MDR fell (64.47%), XDR (9.87%). No PDR cases observed. Pediatric abandonment an increasing concern, regional rising 5.42% (2019) 9.83% (2023). Compared general population, abandoned observed fluoroquinolones (50.00%), Aminogycolsides (60.00%), (70.00%), urinary (60.00%). Resistance (OR = 5.17, p 0.0304) 5.64, 0.0049) key predictors risk. Conclusions: influenced trends, notable peaks CRO. Post-pandemic suggest continued escalation resistance. association between infections highlights need robust stewardship social intervention policies.

Language: Английский

Antibacterial Effects of Bulgarian Oregano and Thyme Essential Oils Alone and in Combination with Antibiotics Against Klebsiella pneumoniae and Pseudomonas aeruginosa DOI Creative Commons
Silvia Mihaylova, Antoаneta Tsvetkova, Sylvia Stamova

et al.

Microorganisms, Journal Year: 2025, Volume and Issue: 13(4), P. 843 - 843

Published: April 7, 2025

Antimicrobial resistance (AMR) poses a global health threat, with multidrug-resistant (MDR) Klebsiella pneumoniae and Pseudomonas aeruginosa contributing to the burden, especially in Bulgaria. This study investigates recent trends of these pathogens Bulgaria evaluates antibacterial effects commercially available oregano (Origanum vulgare) thyme (Thymus vulgaris) essential oils (EOs), both alone combination conventional antibiotics. The chemical composition EOs was analyzed using gas chromatography–mass spectrometry (GC-MS), revealing carvacrol (84.2%) as main component EO thymol (45.74%) EO. Minimum inhibitory concentration (MIC) minimum bactericidal (MBC) values were determined serial dilution method. Oregano exhibited lower MIC MBC (0.039–1.250%) compared (0.156–5.000%) against pathogens. disk diffusion assay showed that exhibits more potent than strains. findings highlight potential adjunctive therapies enhance efficacy antibiotics MDR strains

Language: Английский

Citations

0
The Impact of the COVID-19 Pandemic on Pediatric Microbial Resistance Patterns and Abandonment Rates in Western Romania—An Interdisciplinary Study DOI Creative Commons
Dan Dumitru Vulcănescu, Iulia Cristina Bagiu,

Tiberiu Liviu Dragomir

et al.

Antibiotics, Journal Year: 2025, Volume and Issue: 14(4), P. 411 - 411

Published: April 16, 2025

Background: The COVID-19 pandemic in Romania exacerbated pediatric antimicrobial resistance (AMR). Overuse of broad-spectrum antibiotics may be related to increased multidrug-resistant bacteria. main aim this study was assess AMR trends and phenotypes, while a secondary objective investigate the potential links with hospital abandonment. Methods: This retrospective from Children’s Emergency Hospital “Louis Țurcanu”, Timișoara, focused on patterns 2019 pre-pandemic, 2021 pandemic, 2023 post-pandemic. following phenotypes were assessed: MRSA, MRCoNS, VRE, ESBL, CRO, MDR, XDR, PDR. Results: There 3530 total patients 6885 samples. 69.92% samples resistant at least one class, (72.69% 2019, 67.05% 2021, 69.16% 2023). Specifically, towards penicillins remained high across entire period (57.45–60.93%), classes presented elevated pandemic: cephalosporins (42.91%), combination therapies (40.95%), reserve (38.89%), cyclines (13.83%). As for MRSA MRCoNS peaked during (36.08% 81.43%, respectively) VRE relatively constant. Overall ESBL declined 14.45%, overall CRO (8.81%). MDR fell (64.47%), XDR (9.87%). No PDR cases observed. Pediatric abandonment an increasing concern, regional rising 5.42% (2019) 9.83% (2023). Compared general population, abandoned observed fluoroquinolones (50.00%), Aminogycolsides (60.00%), (70.00%), urinary (60.00%). Resistance (OR = 5.17, p 0.0304) 5.64, 0.0049) key predictors risk. Conclusions: influenced trends, notable peaks CRO. Post-pandemic suggest continued escalation resistance. association between infections highlights need robust stewardship social intervention policies.

Language: Английский

Citations

0