Non‐Covalent Interaction Induced Supramolecular Precipitate with Hetero‐Motif Polyionic Junction for Durable Antimicrobial Activity and Infected Wound Healing DOI Open Access
Xuejiao Wang,

Lianbo He,

Huanling He

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 10, 2025

The advent of the COVID-19 pandemic has underscored pressing demand for antimicrobial materials that offer both durability and efficacy. Herein, successful design fabrication a "water-insoluble" supramolecular precipitate is reported through "bottom-up" assembly polyanion sodium alginate (SA) with motifs A2G Cu2+. This innovative hetero-motif polyionic junction leverages network hydrogen bonds aligning electrostatic interactions, hydrophobic effects to mitigate rapid release active components, providing exceptional long-term efficacy against Staphylococcus aureus (S. aureus), Escherichia coli (E. coli), Candida albicans (C. albicans). Specifically, it retains an impressive 99.9% S. even after enduring 10 successive wash cycles. hydroxyl groups in A2G-Cu-SA confer adhesion wide array substrates. robust adherence complemented by its antibacterial properties, material maintaining rate being submerged water extended period 100 days. In vivo vitro studies substantiate biocompatibility A2G-Cu-SA, while clinical potential evidenced enhanced healing aureus-infected wounds upon titanium sheet coating. innovation meets current need effective antimicrobials contributes sustainable medical advancements.

Language: Английский

Non‐Covalent Interaction Induced Supramolecular Precipitate with Hetero‐Motif Polyionic Junction for Durable Antimicrobial Activity and Infected Wound Healing DOI Open Access
Xuejiao Wang,

Lianbo He,

Huanling He

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 10, 2025

The advent of the COVID-19 pandemic has underscored pressing demand for antimicrobial materials that offer both durability and efficacy. Herein, successful design fabrication a "water-insoluble" supramolecular precipitate is reported through "bottom-up" assembly polyanion sodium alginate (SA) with motifs A2G Cu2+. This innovative hetero-motif polyionic junction leverages network hydrogen bonds aligning electrostatic interactions, hydrophobic effects to mitigate rapid release active components, providing exceptional long-term efficacy against Staphylococcus aureus (S. aureus), Escherichia coli (E. coli), Candida albicans (C. albicans). Specifically, it retains an impressive 99.9% S. even after enduring 10 successive wash cycles. hydroxyl groups in A2G-Cu-SA confer adhesion wide array substrates. robust adherence complemented by its antibacterial properties, material maintaining rate being submerged water extended period 100 days. In vivo vitro studies substantiate biocompatibility A2G-Cu-SA, while clinical potential evidenced enhanced healing aureus-infected wounds upon titanium sheet coating. innovation meets current need effective antimicrobials contributes sustainable medical advancements.

Language: Английский

Citations

0