Tissue and Cell, Journal Year: 2023, Volume and Issue: 84, P. 102165 - 102165
Published: July 12, 2023
Language: Английский
Frontiers in Veterinary Science, Journal Year: 2024, Volume and Issue: 11
Published: Sept. 4, 2024
Cooled semen storage methods result in oxidative stress generated by an imbalance between oxidation rates, specifically reactive oxygen species production, and sperm cell antioxidants, leading to degradation of quality. We aimed investigate the impact adding Eurycoma longifolia (EL) extract as antioxidant supplement medium (IGGKPh extender) on quality fertility potential. EL at concentrations 5, 10, 15, 20 mg/mL was assessed for its capacity IGGKPh extender. Our findings revealed that total phenolic content did not vary significantly across various temperatures tested. However, incubation 5°C found be most effective temperature increasing via 2,2-diphenyl-1-picrylhydrazyl inhibition assay a dose-dependent manner. Supplementation extender with 15 enhance during cold up 48 h (
Language: Английский
Citations
3
Pharmaceutics, Journal Year: 2021, Volume and Issue: 13(12), P. 2055 - 2055
Published: Dec. 1, 2021
Mitochondria are vital organelles in eukaryotic cells that control diverse physiological processes related to energy production, calcium homeostasis, the generation of reactive oxygen species, and cell death. Several studies have demonstrated structural functional mitochondrial disturbances involved development different neuroinflammatory (NI) neurodegenerative (ND) diseases (NI&NDDs) such as multiple sclerosis, Alzheimer’s disease, Parkinson’s Huntington’s amyotrophic lateral sclerosis. Remarkably, counteracting impairment by genetic or pharmacologic treatment ameliorates neurodegeneration clinical disability animal models these diseases. Therefore, nanosystems enabling sustained selective delivery mitochondria-targeted drugs is a novel effective strategy tackle NI&NDDs. In this review, we outline impact dysfunction associated with unbalanced dynamics, altered mitophagy, oxidative stress, deficit, proteinopathies addition, review strategies for mitochondria-specific ligand targeting discuss nanomaterials, nanozymes, drug-loaded developed repair function their therapeutic benefits protecting against restoring preventing death, inhibiting protein aggregates, improving motor cognitive cellular
Language: Английский
Citations
16
Antioxidants, Journal Year: 2024, Volume and Issue: 13(9), P. 1103 - 1103
Published: Sept. 12, 2024
Oxidative stress, associated with diseases and aging, underscores the therapeutic potential of natural antioxidants. Flavonoids, known for scavenging free radicals modulating cell signaling, offer significant health benefits contribute to longevity. To explore their in vivo effects, we investigated antioxidant activity quercetin, apigenin, luteolin, naringenin, genistein, using
Language: Английский
Citations
2
Journal of Pharmacy and Pharmacology, Journal Year: 2022, Volume and Issue: 75(4), P. 466 - 481
Published: Dec. 12, 2022
Acute myocardial ischemia is one of the major causes illness in western society. Reduced coronary blood supply leads to cell death and loss cardiomyocyte population, resulting serious often irreversible consequences on function. Mitochondrial potassium (mitoK) channels have been identified as fine regulators mitochondrial function and, consequently, metabolism whole cell, mechanisms underlying cardioprotection. Interestingly, mitoK represent a novel putative target for treating cardiovascular diseases, particularly infarction, their modulators an interesting tool pharmacological intervention. In this review, we took up challenge selecting flavonoids that show cardioprotective properties through activation channels.A brief overview main information participation induction cytoprotective processes was provided. Then, naringenin, quercetin, morin, theaflavin, baicalein, epigallocatechin gallate, genistein, puerarin, luteolin proanthocyanidins demonstrated be effective activity, mediating many beneficial effects.The pathophysiological role has investigated well impact with particular attention potential prevention disorders.
Language: Английский
Citations
11
Published: July 4, 2023
Male infertility (MI) involves various endogenous and exogenous facts. These include oxidative stress (OS), which is known to alter several physiological pathways it estimated be present at high levels in up 80 % of infertile men. That why since the late 20th Century, relationship between OS MI has been widely studied. New terms have emerged, such as Oxidative Stress Infertility (MOSI), proposed a new category define men with levels. Another important term MOXI: Male, Antioxidants, Infertility. Such refers hypothesis that antioxidants could improve male fertility without use assisted reproductive technology. However, there no evidence-based antioxidant treatments directly seminal parameters or birth ratio. In this regard, controversy about their use. While certain scientists argue against due lack results, others support because safety profile low price. Some uncertainties related for treating are questionable efficacy difficulties know correct dosage. addition, quality methods detection can lead an excessive supplementation, resulting “reductive stress”. problem that, although inflammatory process interdependent closely linked OS, usually ignored. To solve these uncertainties, trends recently emerged. molecules anti-inflammatory potential, also able specifically target tissue; well allow reliable quantification diagnosis. This review aims elucidate main MOXI outline latest research achieve effective therapies clinically relevant outcomes.
Language: Английский
Citations
6
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(18), P. 14260 - 14260
Published: Sept. 19, 2023
Phytoestrogens, such as isoflavones, are bioactive compounds found in plants with defense and protection functions. In the human body, they simulate behavior of hormone estradiol can modulate function male hypothalamic-pituitary-gonadal axis. This study aims to describe effects genistein on sperm quality Wistar rats (male/adult) after a short oral administration protocol (50 mg/day, for 5 days), focusing mitochondrial function. No signs toxicity were observed animals during period. The testicular mass from genistein-treated group was lower than that control group. Isoflavone increased number viable Leydig Sertoli cells, spermatogonia, primary spermatocytes treated rounded spermatid count similar group, decrease elongated spermatids Genistein treatment plasma testosterone levels To best our knowledge, this is first report an vivo demonstrating stimulates overall oxygen consumption rat seminal samples. Therefore, induced pro-spermatogenesis effect, enhanced levels, consumption, improving efficiency. Similar protocols be explored animal infertility issues.
Language: Английский
Citations
5
Antioxidants, Journal Year: 2023, Volume and Issue: 12(8), P. 1626 - 1626
Published: Aug. 17, 2023
Male infertility (MI) involves various endogenous and exogenous facts. These include oxidative stress (OS), which is known to alter several physiological pathways it estimated be present at high levels in up 80% of infertile men. That why since the late 20th century, relationship between OS MI has been widely studied. New terms have emerged, such as Oxidative Stress Infertility (MOSI), proposed a new category define men with levels. Another important term MOXI: Male, Antioxidants, Infertility. This refers hypothesis that antioxidants could improve male fertility without use assisted reproductive technology. However, there are no evidence-based antioxidant treatments directly seminal parameters or birth ratio. In this regard, controversy about their use. While certain scientists argue against due lack results, others support because safety profile low price. Some uncertainties related for treating questionable efficacy difficulties knowing correct dosage. addition, quality methods detection can lead excessive supplementation, resulting “reductive stress”. problem that, although inflammatory process interdependent closely linked OS, usually ignored. To solve these uncertainties, trends recently emerged. molecules anti-inflammatory potential, also able specifically target tissue; well allow reliable quantification diagnosis. review aims elucidate main MOXI outline latest research develop effective therapies clinically relevant outcomes.
Language: Английский
Citations
3
Veterinary Sciences, Journal Year: 2022, Volume and Issue: 9(10), P. 513 - 513
Published: Sept. 21, 2022
To assess sperm quality, it is important to evaluate energy metabolism. The test substance 2.4-dinitrophenol (2.4-DNP) an agent for destroying oxidative phosphorylation. 2.4-DNP shuts off the production of adenosine triphosphate (ATP) from oxidation and then, respiration rate increases. If respiratory chain damaged, there little or no response adding 2.4-DNP. aim this study was analyze activity phosphorylation in semen before after freezing compare obtained data with fertilizing ability sperm. There a reduction rates all species thawing. spermatozoa boars, bulls, stallions, reindeers chicken showed responses 2.4-dinitrophenol. only difference strength substance. After thawing, stimulation by decreased. results our show that not correlated pregnancy egg fertility. However, high correlation between rates. increase could be suitable
Language: Английский
Citations
5
Antioxidants, Journal Year: 2023, Volume and Issue: 12(10), P. 1880 - 1880
Published: Oct. 19, 2023
Many dietary factors can affect sperm traits. We compared the effect of diets rich in pro-oxidant (flaxseed oil) and pro-atherogenic (coconut substances without added antioxidants on semen traits, using rabbit as an animal model. Thirty bucks (8 months old) were fed three for 150 days: CNT (control) a standard diet; HA (high-atherogenic) diet + 3% coconut oil, HO (high-oxidizing) flaxseed oil. Semen samples collected weekly evaluation qualitative traits (kinetics, viability) oxidative damage (MDA cytokines). Blood was at start (T0) end (T8) experimental period assessment isoprostanoids), lipid profile, testosterone. A worsening kinetics viability recorded group. Lipid oxidation seminal plasma, well isoprostanoids blood (F
Language: Английский
Citations
2
Journal of Complementary and Integrative Medicine, Journal Year: 2022, Volume and Issue: 19(3), P. 683 - 690
Published: Jan. 10, 2022
Lead exposure seriously impairs male reproductive function. The protective capacity of Pedalium murex leafy stem and fruit aqueous extracts against lead testicular toxicity is evaluated to find herbals drugs able improve semen quality.Phytochemical screening were performed according classical methods. Twenty four rats divided into groups six each received the following treatments via oral route: distilled water; 0.2% acetate in drinking water with 400 mg/kg P. extract; leaded extract. Treatments administered for 70 days. Body organs weights, sperm parameters histological sections group examined.Flavonoids, tannins, coumarins, alkaloids, lignans found both extracts. intoxication reduced motility count but increased percentage morphologically abnormal sperms. germinal epithelium seminiferous tubules histoarchitecture was disorganized by lead. extract effective reducing induced disruption whereas has not shown any beneficial effect.P. alterations caused
Language: Английский
Citations
4