Foods,
Journal Year:
2023,
Volume and Issue:
12(14), P. 2702 - 2702
Published: July 14, 2023
Consumers’
growing
concern
about
health
and
well-being
has
led
to
increased
interest
in
functional
foods.
This
research
aims
evaluate
the
physicochemical
antioxidant
properties
of
a
plant-based
(PB)
snack
bar
enriched
with
Coprinus
comatus
powder.
The
formulations
exhibited
wide
range
flavor
textural
characteristics.
Two
PB
bars
four
commercial
were
evaluated
by
consumer
panel
healthy
volunteers
(n
=
20).
scored
‘like
extremely’
on
9-point
hedonic
scale.
External
preference
mapping
determined
that
sweetness,
flavors,
cohesiveness,
gumminess,
adhesion
had
greatest
influence
acceptability.
Water
content,
ash,
protein,
fat,
carbohydrate,
reducing
sugar,
resistant
starch,
dietary
fiber
measured.
Nutritional
content
was
enhanced
(omega
3,
protein),
samples
shelf
life
stable
(aw
<
0.29;
moisture
10%).
In
addition,
underwent
simulated
digestion
according
INFOGEST
protocol,
from
comparative
evaluation,
can
be
seen
control
post-prandial
glycemic
responses,
as
observed
different
degree
sugars
released
via
matrix.
further
functionally
addition
their
unique
ingredients
such
comatus.
powder
is
claimed
benefit
diabetes
attracted
terms
its
potential
use
natural
products
possible
benefits.
Frontiers in Endocrinology,
Journal Year:
2021,
Volume and Issue:
12
Published: Oct. 27, 2021
Diabetic
osteoporosis
(DOP)
belongs
to
secondary
caused
by
diabetes;
it
has
the
characteristics
of
high
morbidity
and
disability.
In
present
study,
we
constructed
a
type
1
diabetic
rat
model
administered
chondroitin
sulfate
(200
mg/kg)
for
10
weeks
observe
preventive
effect
on
bone
loss
rats.
The
results
showed
that
can
reduce
blood
glucose
relieve
symptoms
rats;
in
addition,
significantly
increase
mineral
density,
improve
microstructure,
marrow
adipocyte
number
after
administration,
SOD
activity
level
was
upregulated,
as
well
CAT
levels,
indicating
alleviate
oxidative
stress
Chondroitin
also
found
serum
inflammatory
cytokines
(TNF-α,
IL-1,
IL-6,
MCP-1)
inflammation
metabolism
marker
detection
turnover
rats
(decreased
RANKL,
CTX-1,
ALP,
TRACP
5b
levels
were
observed
administration).
At
same
time,
OPG
RUNX
2
expression
higher
treatment,
RANKL
lowered,
OPG/RANKL
ratio
upregulated.
All
above
indicated
could
prevent
STZ-induced
DOP
repair
microstructure;
main
mechanism
through
anti-oxidation,
anti-inflammatory,
regulating
metabolism.
be
used
develop
anti-DOP
functional
foods
diet
interventions
diabetes.
Frontiers in Physiology,
Journal Year:
2022,
Volume and Issue:
13
Published: Aug. 31, 2022
Patients
with
diabetes
have
severe
vascular
complications,
such
as
diabetic
nephropathy,
retinopathy,
cardiovascular
disease,
and
neuropathy.
Devastating
complications
lead
to
increased
mortality,
blindness,
kidney
failure,
decreased
overall
quality
of
life
in
people
type
2
(T2D).
Glycolipid
metabolism
disorder
plays
a
vital
role
the
T2D.
However,
specific
mechanism
action
remains
be
elucidated.
In
T2D
patients,
damage
begins
develop
before
insulin
resistance
clinical
diagnosis.
Endothelial
dysregulation
is
significant
cause
early
event
injury.
Hyperglycemia
hyperlipidemia
can
trigger
inflammation
oxidative
stress,
which
impair
endothelial
function.
Furthermore,
during
pathogenesis
T2D,
epigenetic
modifications
are
aberrant
activate
various
biological
processes,
resulting
dysregulation.
present
review,
we
provide
an
overview
discussion
roles
hyperglycemia-
hyperlipidemia-induced
dysfunction,
inflammatory
response,
modification
Understanding
connections
glucotoxicity
lipotoxicity
injury
may
reveal
novel
potential
therapeutic
target
for
complications.
Antioxidants,
Journal Year:
2023,
Volume and Issue:
12(5), P. 994 - 994
Published: April 25, 2023
Oxidative
stress
is
an
important
factor
in
the
development
of
type
2
diabetes
(T2D)
and
associated
complications.
Unfortunately,
most
clinical
studies
have
failed
to
provide
sufficient
evidence
regarding
benefits
antioxidants
(AOXs)
treating
this
disease.
Based
on
known
complexity
reactive
oxygen
species
(ROS)
functions
both
physiology
pathophysiology
glucose
homeostasis,
it
suggested
that
inappropriate
dosing
leads
failure
AOXs
T2D
treatment.
To
support
hypothesis,
role
oxidative
described,
together
with
a
summary
for
management
diabetes.
A
comparison
preclinical
indicates
suboptimal
might
explain
lack
AOXs.
Conversely,
possibility
glycemic
control
be
adversely
affected
by
excess
also
considered,
based
ROS
insulin
signaling.
We
suggest
AOX
therapy
should
given
personalized
manner
according
need,
which
presence
severity
stress.
With
gold-standard
biomarkers
stress,
optimization
may
achieved
maximize
therapeutic
potential
these
agents.
Foods,
Journal Year:
2023,
Volume and Issue:
12(14), P. 2702 - 2702
Published: July 14, 2023
Consumers’
growing
concern
about
health
and
well-being
has
led
to
increased
interest
in
functional
foods.
This
research
aims
evaluate
the
physicochemical
antioxidant
properties
of
a
plant-based
(PB)
snack
bar
enriched
with
Coprinus
comatus
powder.
The
formulations
exhibited
wide
range
flavor
textural
characteristics.
Two
PB
bars
four
commercial
were
evaluated
by
consumer
panel
healthy
volunteers
(n
=
20).
scored
‘like
extremely’
on
9-point
hedonic
scale.
External
preference
mapping
determined
that
sweetness,
flavors,
cohesiveness,
gumminess,
adhesion
had
greatest
influence
acceptability.
Water
content,
ash,
protein,
fat,
carbohydrate,
reducing
sugar,
resistant
starch,
dietary
fiber
measured.
Nutritional
content
was
enhanced
(omega
3,
protein),
samples
shelf
life
stable
(aw
<
0.29;
moisture
10%).
In
addition,
underwent
simulated
digestion
according
INFOGEST
protocol,
from
comparative
evaluation,
can
be
seen
control
post-prandial
glycemic
responses,
as
observed
different
degree
sugars
released
via
matrix.
further
functionally
addition
their
unique
ingredients
such
comatus.
powder
is
claimed
benefit
diabetes
attracted
terms
its
potential
use
natural
products
possible
benefits.
