Single-atom transition metals (Rh, Ir, Co) doped silicon carbide nanotubes (SiCNT) as nonenzymatic nitrotyrosine (NTS) sensor: Insight from theoretical calculations

Computational and Theoretical Chemistry, Journal Year: 2023, Volume and Issue: 1227, P. 114250 - 114250

Published: July 26, 2023

Language: Английский

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Porous Materials for Early Diagnosis of Neurodegenerative Diseases

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 6, 2025

Abstract Neurodegenerative diseases, particularly Alzheimer's disease and Parkinson's disease, present formidable challenges in modern medicine due to their complex pathologies the absence of curative treatments. Despite advances symptomatic management, early diagnosis remains essential for mitigating progression improving patient outcomes. Traditional diagnostic methods, such as MRI, PET, cerebrospinal fluid biomarker analysis, are often inadequate detection these diseases. Emerging porous materials, including metal–organic frameworks (MOFs), covalent–organic (COFs), MXene, zeolites, silicon, offer promising new approaches neurodegenerative These characterized by highly tunable physicochemical properties, have potential capture concentrate disease‐specific biomarkers amyloid‐beta (Aβ), tau protein, alpha‐synuclein (α‐Syn). The integration materials into advanced biosensors real‐time holds promise revolutionizing neurodiagnostic, enabling non‐invasive, sensitive, specific platforms. Furthermore, incorporation artificial intelligence (AI) machine learning (ML) techniques analysis sensor data enhances accuracy allows more efficient interpretation profiles. AI ML can optimize feature selection, improve pattern recognition, facilitate prediction progression, making them indispensable tools personalized medicine. This review explores diagnostics, emphasizing design, functionality, synergistic role advancing clinical applications.

Language: Английский

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Neuroprotective role of Epigallocatechin-3-Gallate, Albeginin and Melanoxetin in Alzheimer's Disease

Phytomedicine Plus, Journal Year: 2025, Volume and Issue: unknown, P. 100740 - 100740

Published: Jan. 1, 2025

Language: Английский

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Trajectory of Cardiogenic Dementia: A New Perspective

Journal of Cellular and Molecular Medicine, Journal Year: 2025, Volume and Issue: 29(2)

Published: Jan. 1, 2025

ABSTRACT The functions of the heart and brain are closely linked essential to support human life by heart‐brain axis, which is a complex interconnection between brain. Also, cardiac function cerebral blood flow regulate brain's metabolism function. Therefore, deterioration may affect cognitive increase risk dementia. Cardiogenic dementia defined as due diseases such failure, myocardial infarction, atrial fibrillation. prevalence impairment in patients with failure was 29%. In addition, coronary artery disease (CAD) also associated development impairment. CAD reduction contractility reduced increased patients. Furthermore, infarction subsequent systemic haemodynamic instability promote progression cardiogenic These findings indicated that many implicated Nevertheless, underlying mechanism for not fully elucidated. Consequently, this review aims discuss potential mechanisms involved pathogenesis

Language: Английский

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Oxidative Stress and the Central Nervous System

Antioxidants, Journal Year: 2025, Volume and Issue: 14(1), P. 110 - 110

Published: Jan. 19, 2025

Reactive oxygen and nitrogen species (ROS; RNS) are natural bioproducts of cellular metabolism, particularly produced within the mitochondria during energy production [...]

Language: Английский

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