Astrocytes in Neurodegeneration: Inspiration From Genetics

Frontiers in Neuroscience, Journal Year: 2022, Volume and Issue: 16

Published: June 24, 2022

Despite the discovery of numerous molecules and pathologies, pathophysiology various neurodegenerative diseases remains unknown. Genetics participates in pathogenesis neurodegeneration. Neural dysfunction, which is thought to be a cell-autonomous mechanism, insufficient explain development disease, implying that other cells surrounding or related neurons, such as glial cells, are involved pathogenesis. As primary component astrocytes play variety roles maintenance physiological functions neurons cells. The neurodegeneration also influenced by reactive astrogliosis response central nervous system (CNS) injuries. Furthermore, those risk-gene variants identified neurodegenerations astrocyte activation senescence. In this review, we summarized relationships between gene four diseases, including Alzheimer’s disease (AD), amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), Parkinson’s (PD), provided insights into implications neurodegenerations.

Language: Английский

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Review of the therapeutic potential of Forsythiae Fructus on the central nervous system: Active ingredients and mechanisms of action

Journal of Ethnopharmacology, Journal Year: 2023, Volume and Issue: 319, P. 117275 - 117275

Published: Oct. 4, 2023

Traditional Chinese medicine has gained significant attention in recent years owing to its multi-component, multi-target, and multi-pathway advantages treating various diseases. Forsythiae Fructus, derived from the dried fruit of Forsythia suspensa (Thunb.) Vahl, is one such traditional with numerous vivo ex therapeutic effects, including anti-inflammatory, antibacterial, antiviral properties. Fructus contains more than 200 chemical constituents, forsythiaside, forsythiaside A, B, isoforsythiaside, forsythin, phillyrin being most active ingredients. exerts neuroprotective effects by modulating pathways, oxidative stress, anti-inflammation, NF-κB signaling, 2-AG, Nrf2 acetylcholinesterase, PI3K-Akt ferroptosis, gut-brain axis, TLR4 endoplasmic reticulum PI3K/Akt/mTOR PPARγ signaling pathway. This review aims highlight potential on central nervous system summarize current knowledge ingredients their different pathways involved neuroprotection. In this review, we conducted a comprehensive search databases (PubMed, Google Scholar, Web Science, China Knowledge Resource Integrated, local dissertations books) up until June 2023 using key terms as forsythia suspensa, phillyrin, Alzheimer′s disease, Parkinson's ischemic stroke, intracerebral hemorrhage, traumatic brain injury, aging, herpes simplex virus encephalitis. Our findings indicate that own have demonstrated promising Future clinical studies should be establish precise dosage standard guidelines for effective application treatment neurological disorders.

Language: Английский

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Rosa moschata ameliorates haloperidol-induced Parkinson's disease via reduction of neurodegeneration and oxidative stress

Asian Pacific Journal of Tropical Biomedicine, Journal Year: 2025, Volume and Issue: 15(1), P. 24 - 33

Published: Jan. 1, 2025

Objective: To investigate the effect of Rosa moschata ( R. ) extract on haloperidol-induced Parkinson’s disease (PD) in rats. Methods: Haloperidol (1 mg/kg) was given to rats intraperitoneally for 3 weeks induction PD. (150, 300 and 600 administered orally 21 days. The neuroprotective role leaf PD explored by performing neurobehavioral tests RT-PCR analysis measuring neurotransmitters oxidative stress biomarkers. Results: An improvement motor functions muscle strength observed treated with extract. levels dopamine, serotonin, noradrenaline, superoxide dismutase, catalase, glutathione, dismutase were significantly increased P < 0.001), whereas acetylcholinesterase malondialdehyde markedly decreased treatment 0.001). also downregulated mRNA expressions IL-1β , α-synuclein IL-1α TNF-α brain tissue. Moreover, histopathological indicated that neurofibrillary tangles plaques noticeably a dose-dependent manner Conclusions: alleviates reducing neurodegeneration. It may be used management However, additional studies are required confirm its efficacy molecular mechanisms.

Language: Английский

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Oxidative Stress: A New Pathophysiological Pathway in Parkinson’s Disease and a Potential Target of the Brain‐Sport Crosstalk

Parkinson s Disease, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

Oxidative stress (OS), a condition that occurs when the balance between reactive oxygen species production and antioxidant defense mechanisms is disrupted, has been implicated in pathogenesis of several neurological conditions, including neurodegenerative vascular disorders. Ferroptosis mechanism mediating OS-induced damage, with growing evidence specific involvement both Parkinson's disease (PD) ischemic stroke. Regular physical activity may have an effect by increasing nonenzymatic enzymatic antioxidants. Among biological mediators activity, irisin act as agent capable inducing systemic changes crossing brain-blood barrier. This review aims to describe main role OS pathophysiology PD, highlighting putative emphasizing potential targeting possible shared preventive symptomatic treatment approach.

Language: Английский

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Unleashing the potential: 40 Hz multisensory stimulation therapy for cognitive impairment

Journal of Central Nervous System Disease, Journal Year: 2025, Volume and Issue: 17

Published: March 1, 2025

Cognitive impairment encompasses a spectrum of disorders marked by acquired deficits in cognitive function, potentially leading to diminished daily functioning and work capacity, often accompanied psychiatric behavioral disturbances. Alzheimer's disease (AD) Post-stroke (PSCI) are significant causes decline. With the global population getting older, AD PSCI becoming major health concerns, underscoring critical necessity for successful treatment options. In recent years, various non-invasive biophysical stimulation techniques, including ultrasound, light, electric, magnetic stimulation, have been developed central nervous system diseases. Preliminary clinical studies demonstrated feasibility safety these techniques. This review discuss impact 40 Hz multisensory on cerebral outcomes, progression both animal models individuals exhibiting deficits, such as PSCI. Furthermore, it summarizes potential neural pathways involved this therapeutic modality synthesizing evidence from variety within field. Subsequently, evaluates existing constraints technique underscores advantages therapy with goal enhancing management care

Language: Английский

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Global research trends in inflammaging from 2005 to 2024: a bibliometric analysis

Frontiers in Aging, Journal Year: 2025, Volume and Issue: 6

Published: April 10, 2025

Background Inflammaging, defined as chronic low-grade inflammation associated with aging, is considered a key factor in many age-related diseases. Despite growing research, comprehensive assessments of trends and focuses on this field over the past 2 decades remain lacking. Objective To comprehensively analyze literature development trends, scientific priorities, their evolution inflammaging from 2005 to 2024 using bibliometric analysis. Methods Academic was retrieved Web Science Core Collection. CiteSpace software used tool annual publication contributing countries/regions, leading research institutions, primary journals, keyword co-occurrence, including clustering burst analysis field. Results The study included 1,800 eligible articles, demonstrating consistent growth publications 20 years. United States Italy were principal contributors. University Bologna had highest publication. Professor Claudio Franceschi has been figure Journal shows that themes predominantly focus molecular biology/immunology medicine/clinical fields. Keyword identifies major hotspots “inflammaging,” “Crohn’s disease,” “periodontitis,” “immunosenescence,” “skeletal muscle,” “gut microbiota,” “Parkinson’s disease.” Emerging term indicates shift specific inflammatory diseases broader aging immune modulation studies. Conclusion This first systematic assessment reveals sustained academic an increasingly deep focus.

Language: Английский

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Natural anti-neuroinflammatory inhibitors from Aglaia odorata

Journal of Asian Natural Products Research, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 8

Published: April 21, 2025

Eleven compounds were isolated from the n-butanol extract of Aglaia odorata Lour, including one undescribed lignan, curlignan-4-O-β-D-glucopyranoside (1), and ten known (2-11). Their structures characterized by comprehensive spectral analysis, nuclear magnetic resonance (1D 2D NMR), mass spectrometry (MS), electronic circular dichroism (ECD). The inhibitory effects these on nitric oxide (NO) production in lipopolysaccharide (LPS) stimulated BV-2 microglia evaluated. experimental results indicated that anti-neuroinflammatory activities 1, 3, 4, 6, 7, 9 10 significantly better than those positive control minocycline (IC50 = 41.34 ± 3.55 μM), with IC50 values ranging 1.31 to 15.70 μM.

Language: Английский

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Aberrant CHCHD2-associated mitochondriopathy in Kii ALS/PDC astrocytes

Acta Neuropathologica, Journal Year: 2024, Volume and Issue: 147(1)

Published: May 15, 2024

Language: Английский

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Neuroinflammation in Parkinson’s disease: focus on the relationship between miRNAs and microglia

Frontiers in Cellular Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: July 26, 2024

Parkinson’s disease (PD) is a prevalent neurodegenerative disorder that affects the central nervous system (CNS). Neuroinflammation crucial factor in pathological advancement of PD. PD characterized by presence activated microglia and increased levels proinflammatory factors, which play role its pathology. During immune response PD, regulation significantly influenced microRNA (miRNA). The excessive activation microglia, persistent neuroinflammation, abnormal polarization macrophages brain can be attributed to dysregulation certain miRNAs. Additionally, there are miRNAs possess ability inhibit neuroinflammation. miRNAs, small non-coding epigenetic regulators, have modulate microglial activity both normal conditions. They also significant impact on promoting communication between neurons microglia.

Language: Английский

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Pharmacological Potential of the Standardized Methanolic Extract of Prunus armeniaca L. in the Haloperidol-Induced Parkinsonism Rat Model

Evidence-based Complementary and Alternative Medicine, Journal Year: 2022, Volume and Issue: 2022, P. 1 - 15

Published: Sept. 29, 2022

Parkinson’s disease (PD) is a complex, age-related neurodegenerative that causes neuronal loss and dysfunction over time. An imbalance of redox potential oxidative stress in the cell diseases neurons. Plants are rich source bioactive substances attenuate variety neurological disorders. The aim present study was to evaluate Prunus armeniaca L. methanolic extract (PAME) for anti-Parkinson activity rats. PD induced with haloperidol (1 mg/kg, IP). PAME administered orally at 100, 300, 800 mg/kg dose levels 21 days. Behavioral studies (catalepsy test, hang open-field narrow beam walk, hole-board test), biomarkers (SOD, CAT, GSH, MDA) levels, neurotransmitters (dopamine, serotonin, noradrenaline) acetylcholinesterase were quantified brain homogenate. Liver function tests (LFTs), renal (RFTs), complete blood count (CBC), lipid profiles measured blood/serum samples note side effects selected doses. Histopathological analysis performed on (anti-PD study), liver, heart, kidney (to check toxicity these vital organs). Motor functions improved behavioral studies. Dopamine, noradrenaline significantly increased ( $P<0.001$ ), whereas level decreased id="M2"> ). superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH) increased, while malondialdehyde (MDA) nitrite PAME-treated groups compared control group, hence reducing stress. incidence determined by biochemical LFT RFT testing. histopathological indicated neurofibrillary tangles plaques dose-dependent manner groups. Based data, it concluded possessed good activity, rationalizing plant’s traditional use as neuroprotective agent.

Language: Английский

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